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Comparing Advanced Modality Needs, Part 1: Manufacturing

ADCs, AOCs, ATMPs, cell and gene therapies, and oligonucleotide therapeutics represent distinct but interconnected approaches to precision medicine. Let's take a closer look at their manufacturing needs.

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EDITOR'S DESK

Contextualizing Data To Enable AI And Prevent Knowledge Leaks
Bioprocess Online's Tyler Menichiello interviews Martin Kockx, a principal manufacturing systems engineer at Vertex Pharmaceuticals, on his presentation at 2026 BPI, “Transforming Biomanufacturing: Why Architecture Must Precede Analytics."

On The Ground At BPI: Jacqualyn Schulman, Ph.D., On Accelerating Clonal CLD

An interview with Jacqualyn Schulman, Ph.D., a principal scientist at Bristol Myers Squibb (BMS), on her presentation at BPI 2026, “Fast-Tracking CHO Cell Line Development Using Integrated Engineering Strategies.”

AstraZeneca's Focus On Predictive Control, Semi-Autonomous Processing

This article captures key takeaways from a BioProcess International keynote by Preeya Boppana, director of MSAT process analytics and laboratories at AstraZeneca, titled “Transforming Biologics Manufacturing: Leveraging Predictive Analytics and Advanced Process Control for Next-Generation Operations.”

Prioritizing Quality Over Everything

Regulatory compliance and cGMP manufacturing expert Tatyana Matveeva, Ph.D., explains the role and importance of a quality unit in an organization, as well as what happens when it’s compromised.

Evaluating The Levers Driving Productivity In Bioprocessing

Experts discuss where productivity gains can be achieved and how development teams should seek to improve process performance in this recap of the Bioprocess Online Live event "The Levers And Tradeoffs That Drive Process Productivity."

GUEST COLUMNISTS

Closing The Gap Between Modeling And GMP Predictive Control
Predictive control offers opportunities to improve process consistency, reduce variability, and respond to changing manufacturing conditions before they cause deviations.
IT/OT Convergence Could Lighten Biopharma's Automation Burden
Integration lets frameworks talk to each other through middleware. Convergence brings them under the same architecture, which can can reduce costs and maintenance.
Beyond The Plate Count: How To Build A Defensible Environmental Monitoring Trend Review
Determining whether a drug manufacturing environment is stable, drifting, or developing a recurring loss-of-control signal requires integrated trend evaluation.
Want More Sustainable Biopharma Packaging? Try These Levers
Biopharmaceutical packaging optimization must not compromise the goods inside or compliance, so sustainable packaging developers might need to think outside the box.
What Europe's Draft Annex 22 Actually Asks Of Human Oversight Of AI
The European Commission and the Pharmaceutical Inspection Co-operation Scheme (PIC/S) consulted on draft Annex 22, Artificial Intelligence. Here's what you should know.
How To Keep Your 'Big Bang' Platform Switch From Becoming A Big Bust
Leaders at a Roche fill/finish facility describe the tactile steps involve to change EMS, ERP, and WMS all at once with no rollback option.
How Is Your Glass Supplier Adapting To Europe's Energy Crisis?
Europe's glass manufacturers, including those making pharmaceutical lab glassware, have experienced a series of energy shocks. Many have adopted sustainability practices.
Fine-Tuning Bioseparation Column Geometry With 3D-Printed Monoliths
If geometric control, not retention, is the priority in viral vector separation, research group says high-resolution 3D-printing chromatography monoliths can be useful.

BIOPROCESSING WHITE PAPERS

Accelerating ADC Analytical Method Development Through Platform Innovation
Leverage a platform-based analytical development strategy to accelerate ADC IND readiness through early CQA identification, reduced development risk, and streamlined progression from development to patients.

The Strategic Value Of In-House Delumping For Homogeneous API Production
9/9/2026

API batch homogeneity supports efficient manufacturing. Controlled delumping improves powder flow and chargeability while maintaining particle size integrity and reducing GMP-scale risks.
How To Take Your Process To A Closed System
4/22/2025

Understand the critical considerations for implementing closed systems in bioproduction, from vessel selection to workflow customization for optimal efficiency and safety.
A Guide To Accelerating Cell Line Development For Commercial Production
7/11/2025

Explore the challenges associated with cell line development in the production of biologics, and solutions that can help biotech developers evade the pitfalls of misinformed decision-making.
Data-Centric Organoid Services For Predictive Drug Response And Next-Generation Oncology Research
10/1/2026

Patient-derived organoids are gaining traction as translational tools in oncology, but their value depends on the quality and context of the data they generate, not the models alone.
Improving AAV Manufacturing: Advancements In Full Capsid Enrichment
8/19/2026

As AAV manufacturing matures, integrated optimization of capture, buffer chemistry, load conditioning, and AEX polishing enables scalable full capsid enrichment, improving product quality and manufacturability.

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BIOPROCESSING APP NOTES & CASE STUDIES

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EDITORIAL COLLECTIONS KNOWLEDGE CENTER

Editorial Collections are subscriber-only, curated resources that combine expert interviews, feature articles, and industry analysis to help readers better understand emerging trends, operational challenges, regulatory developments, and best practices shaping the biopharma industry.

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