Bioprocessing Application Notes & Case Studies

  1. High-Density Vero Cell Perfusion Culture in BioBLU® 5p Single-Use Vessels

    Read why Fibra-Cel® disks are a promising alternative attachment matrix with a high surface-to- volume ratio and provide a three-dimensional environment that protects cells from damaging shear forces, helping to achieve high cell densities.

  2. Parallel CHO Cell Cultivation In Eppendorf BioBLU® c Single-Use Bioreactors

    Parallel operation of multiple bioreactors and the use of single-use equipment can help reducing development times and ultimately costs.

  3. An Innovative Solution To Flexibly Meet Unique Primary Packaging Requirements

    A customer enlisted Catalent to support their child-resistant blister packaging requirements for a global Phase III study. A flexible design was created with an integrated blister card that could also support larger study requirements of 1.9 million monthly dosing cards. Through customized commercial blistering equipment a solution was provided that would accommodate the customer’s growing demands for clinical supplies.

  4. Unlock Oral Delivery Potential For Macromolecules With A Parallel Screening Approach

    Identifying the optimal formulation and dose form which shows an increase more than 20 times in the oral bioavailability of Salmon Calcitonin.

  5. Developing Oral Dosage Forms: An Approach For Faster Path To Market

    How an agnostic and data-driven approach early on can optimize the development pathway to bring the molecule to the market faster.

  6. New Performance Assay For Eshmuno® P Resins

    To reduce the variability in the measurement of the anti-A and anti-B titers, an assay was developed for the routine quality control testing of Eshmuno® P resins.

  7. Chromatography Resins For The Removal Of Unwanted Anti-A And Anti-B Antibodies

    Resins allow customers to design the immunoglobulin purification processes with a primary goal of reducing patient risk through an additional chromatography operation.

  8. Medium Preparation For Single-Use Fermentation

    Single‑use fermenters are becoming an increasingly viable alternative to stainless steel, offering less time is spent on equipment preparation and qualification prior to start-up as well as routine maintenance and requalification of the equipment.

  9. Single-Use Stirred Tank Fermentor System Performance Comparison

    The process design proven for one fermentor system is not always directly transferrable to other system formats without adaptation. Here, we compare the performance of the XDR‑500 MO fermentor with the XDR‑50 MO system.

  10. Roivant Sciences Accelerates Process Development To Speed Orphan Therapy To Market

    This case study shares the work of GE’s Fast Trak Services team to help accelerate development of a process for cGMP production of material for toxicology studies.