Bioprocessing Application Notes & Case Studies

1. Upstream Process Intensification With Dynamic Perfusion 11/9/2026

   A fixed-feed approach to perfusion offers a simpler route to intensification, matching steady-state productivity at 50 L scale while consuming less media and requiring fewer operator interactions.

2. Advancing Downstream Purification 11/4/2026

   Aggregate and variant clearance for bispecifics, ADCs, and fusion proteins looks different with frontal-mode cation exchange and mixed-mode selectivity, including fewer process steps.

3. Chromatography Resin – Stability And Resin Life Cycle 11/4/2026

   Protein A resin lifetime drives resin volume and process cost. Repeated caustic cleaning and regeneration cycles test whether binding capacity and impurity clearance hold up across competing resins.

4. BPAL Case Study: Solving Downstream Purification Challenges For Partners 10/29/2026

   An aggregation-prone monoclonal antibody exposed the limits of a standard Protein A platform. A staged screening and column study tested whether tailored capture and polishing could improve recovery and purity.

5. 3-In-1 Protocol For Rapid CAR-T Cell Manufacturing 10/28/2026

   Closing the process and merging three steps into one perfusion run brings CAR-T manufacturing down to roughly a week, with fewer open events and lower batch failure risk.

6. Using Human-Centered Engineering To Improve HPLC Solvent Handling 10/15/2026

   Real-world HPLC workflows show how closed-system solvent handling can address contamination, downtime, and waste across laboratory settings.

7. Supply Chain Diversification In Biopharmaceutical Manufacturing 10/15/2026

   Single-source dependencies in biologics manufacturing carry risks that surface as programs scale toward commercial production. 

8. Improving Formulation And Aliquoting Efficiency With Mixing Solutions 10/14/2026

   Separate formulation, filtration and aliquoting add transfers and integrity tests. A single closed flowpath can improve time, yield and contamination control.

9. High-Yield Cell Therapy Bioproduction 10/14/2026

   Producing billions of dental pulp stem cells strains static culture and complicates harvest. A closed planar perfusion approach offers another route, with scale-up lessons from one developer.

10. Adherent PSC Expansion: Key Considerations For Scalable Manufacturing 10/13/2026

    Adherent multilayer vessels let PSC cultures scale without changing familiar media and handling, but coating volumes, seeding density, and harvest recovery all need rethinking.