Bioprocessing Application Notes & Case Studies

  1. Virus Reduction Of An Affinity Capture Step - Viral Clearance For Protein A

    Evaluating how much a process step contributes to viral clearance is an essential part of process validation in order to be sure you are manufacturing safe drugs. Learn more about how HiScale 10/40, packed with MabSelect PrismA, is a reliable choice for the capture step in a virus clearance study.

  2. 2,000 L HyPerforma Single-Use Bioreactor Evaluation

    The stirred-tank reactor is the most commonly utilized reactor type in biotechnology. Read more about the Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.). It is designed as a stirred-tank reactor for animal cell culture and has the unique advantage of utilizing completely single-use product contact surfaces.

  3. Direct To Representative Sample Distribution Services

    Pharmaceutical manufacturers use a range of marketing channels to promote their prescription drug product. In the United States, one of those channels is to have Pharmaceutical Sales Representatives ‘hand carry’ samples to the health care practitioners within their territories.

  4. Volume Reduction And Process Optimization With Cadence™ Inline Concentrator

    See how this solution not only provides additional capital savings but will also resolve potential manufacturing floor space limitations.

  5. Vero Perfusion, Packed-Bed Vessels Intensify Vaccine Production

    Read how the Eppendorf BioBLU 5p Single-Use Vessel prepacked with Fibra-Cel disks is an excellent platform for high-density Vero cell culture.

  6. rAAV Production In Suspension CAP GT® Cells In BioBLU® 3c And 10c Single-Use Vessels

    Researchers at Cevec® Pharmaceuticals adapted a small scale shake flasks rAAV production process to stirred-tank bioreactors and scaled it up in BioBLU Single-Use Vessels from a working volume of 2 L to 10 L. Scale-up in bioreactors was based on constant power input/volume. It led to comparable cell growth and virus production at both scales and to the original shake flask process.

  7. Reducing Cost within Advanced Therapy Clinical Trials

    The challenge for advanced therapy companies is that they need to develop a supply chain that delivers their therapy, at scale, without adding significantly to the cost of goods sold (COGS). In this case study, we’ll demonstrate how a company saw 55% cost savings across its distribution system, and increased visibility of its supply chain through meaningful data through partnering with Fisher BioServices and Fisher Clinical Services.

  8. Development Of Qualified Cold Chain Solution For Vaccine Transport To Uganda

    Maintaining the cold chain is a challenge when handling biologics such as vaccines, particularly when the clinic is in a remote location. Learn more about how Fisher Bioservices developed a qualified cold chain solution to transport Ebola vaccines to Uganda.

  9. Modular Bioprocessing Alleviates Drug Manufacturing Woes For BeiGene

    Building a bioprocessing facility is usually a complicated process and requires partnering with not only drug developers, but also many different experts in various industries. BeiGene, a commercial-stage biotechnology company, can attest to these challenges.

  10. Benefits Of Mixed-Mode Cation Exchange Chromatography

    This note addresses the performance of Pall’s mixed-mode cation exchange (CEX) CMM HyperCel sorbent, which can be applied to both monoclonal antibody (mAb) polishing and recombinant protein purification.