Bioprocessing Application Notes & Case Studies

1. Bio4C™ ProcessPad’s New Pattern Search Feature Helps Engineers Find Anomaly Patterns In Historical Machine Data 10/21/2020

   Owing to the sheer volume of data streaming from sensor profiles, anomalies observed during process monitoring in historical data are extremely difficult to search due to a lack of time series search tools. See how Bio4C™ ProcessPad’s new “Pattern Search” feature provides process engineers this ability to easily extract an anomaly profile from a time series for a time-range or within a batch.

2. Surface Plasmon Resonance-Based Assays For Monitoring SARS-CoV 2 Surface Glycoprotein Protein Binding Interactions 10/19/2020

   The envelope glycoprotein or "spike" from the novel coronavirus (SARS-CoV-2) mediates the virus binding to Angiotensin-converting enzyme 2 (ACE2) for cellular entry and consequently is a prime target for therapeutic development, including antibody-based therapeutics. In this technical note, we investigate the interactions between the spike glycoprotein binding with ACE2.

3. Delivering Clinical Trial Medications Direct-To-Patient 10/15/2020

   In a perfect world patients enrolled in clinical trials would live a short distance from the investigator site where they receive their treatment. Unfortunately that is not always the case. In recent years the Direct-to- Patient model, which brings medical procedures to a patient’s home, has emerged as a solution for Sponsors to increase patient recruitment and retention in clinical trials.

4. Next-Generation Monitoring Of Bioprocessing To Enable Smart Data Management And Analysis 10/14/2020

   Every step of the bioprocess lifecycle generates a massive amount of data at an incredibly fast rate. Given the need to collect and fluidly handle massive amounts of data being generated with tremendous velocity, a new approach to data management is essential. A new platform that includes digital technologies/data management, process analytical technologies and intensified processing will drive next generation bioprocessing.

5. Biotechnology Company Utilizes Process Data Management Software To Support Its Manufacturing Operations 10/13/2020

   Precision BioSciences (NASDAQ: DTIL) is a clinical stage biotechnology company developing allogeneic CAR T and in vivo gene correction therapies. Without automated data acquisition capabilities, batch data is manually recorded and transcribed into an Excel file, which is then e-mailed or shared on a network folder. Data is then verified and a PDF entered into the ELN for QA. All of this requires manual workflows. Learn how process data management software automated this workflow.

6. Droplet Digital PCR Applications Guide 10/13/2020

   Droplet Digital polymerase chain reaction (ddPCR™) was developed to provide high-precision, absolute quantification of nucleic acid target sequences with wide-ranging applications for both research and clinical diagnostic applications. ddPCR measures absolute quantities by counting nucleic acid molecules encapsulated in discrete, volumetrically defined water-in-oil droplet partitions. Droplet Digital PCR using Bio-Rad’s QX100™ or QX200™ Droplet Digital PCR system overcomes the previous lack of scalable and practical technologies for digital PCR implementation.

7. Electronic Lab Notebooks - Implementing Next-Generation Laboratory Informatics 10/11/2020

   Electronic Lab Notebooks are a key component of an electronic lab environment that helps scientists execute faster, more informed, high-quality science. It’s a vision scientists have talked about for decades.

8. Enhancing The Solubility Of L-Tyrosine In Cell Culture Media Applications 10/9/2020

   Because L-Tyrosine is an important amino acid for protein synthesis and cellular metabolism, finding a solution to its solubility challenge can be critical to maximize process performance. 

9. How Intelligent Collaboration Transformed A Generic Into A Best-In-Class New Drug 10/7/2020

   A pharmaceutical developer specializing in leveraging common compounds for new indications needed to transform a generic solid active pharmaceutical ingredient (API) into a commercial, sterile injectable approved by regulators. Read how collaboration and the drive to find a workable solution led to a successful drug development program.

10. A Small-Scale Model To Increase Yield In Cell Culture Perfusion Of mAb At Large Scale 9/28/2020

    As process intensification is adopted into large scale manufacturing, the responsibility on scale-down models to accurately represent the expanded operating space quickly follows. Perfusion continues to be one such operating mode which lends itself to adding benefit at the manufacturing scale while adding complexity to the small-scale approach. The purpose of the described study was to develop a reliable small-scale model of our perfusion process in the ReadyToProcess WAVE 25 Rocker bioreactor and WAVE Cellbag 50 L.