Bioprocessing Application Notes & Case Studies

  1. In Vitro Glycoengineering – Suitability For BioPharma Manufacturing 11/23/2022

    In this assessment of the in vitro glycoengineering technology we determine is it is suitable for the development, manufacturing, and analysis of therapeutic proteins.

  2. Automated Aseptic Filling: Unprecedented Flexibility To Filling Well 11/18/2022

    Learn about a high performing bulk filtration, filling and draining platform for primary packages such as single use bags, bottles and vials. 

  3. SELECT SERIES Cyclic IMS System 11/17/2022

    Explore the utility of Electron Capture Dissociation (ECD) on the SELECT SERIES Cyclic IMS instrument for unambiguous assignment of glycosylation site locations for 11 Oglycopeptide species of ENBREL (etanercept).

  4. Capture Of Bispecific Antibodies And Removal Of Product-Related Impurities 11/17/2022

    Many antibody variants are prone to aggregation or to forming product-related impurities. Explore the application of a resin with novel selectivity to purify challenging entities.

  5. Evaluating A Flexible LC Platform 11/16/2022

    Learn about a premier system offering a flexible LC platform that can be broadly deployed across labs to support the analytical needs in the development and manufacturing of biotherapeutics.

  6. Successful Filter Integrity Testing Using The WIT Method 11/15/2022

    Explore the collected best methods/practices to give filter end users the best possible chance of performing a successful water intrusion test.

  7. Biologics Developability: Stability Optimization Of Engineered mAbs 11/15/2022

    Learn why this protein science group found it important to build developability profiles from biophysical stability attributes of their candidates and how they did it.

  8. Generating A Robust Host Cell Line For A Cell Line Development Platform 11/14/2022

    Learn how cell performance within the context of the cell line development workflow was confirmed with the successful isolation of stable, high-producing clones from three model monoclonal antibodies.

  9. Impact Of DMSO And Freezing Technique In Developing A High Cell Density Cryopreservation Process For Upstream Bioprocessing 11/10/2022

    Developing a seed train for upstream bioprocessing involves optimizing many conditions – the medium, the feed, the starting inoculum density, etc. Integrating high cell density cryopreservation (HCDC) in the seed train also means considering parameters like the choice of cryoprotectant and freezing technique.

  10. Validation Of ICON™ Automated Cell Counting And Viability Assay 11/10/2022

    Explore this study aimed at validating ICON’s Viability Assay by measuring cell samples with a range of expected concentrations and viabilities.