Bioprocessing Application Notes & Case Studies

1. Accurate HC-LC Pairing And A Close-To-Nature Solution For bsAbs 9/11/2023

   Examine how a proprietary technology ensures high levels of accurate HC-LC pairing without detriment to critical quality attributes such as titer, binding affinity, stability, and immunogenicity.

2. mRNA-LNP Nucleic Acid Assessment From Distinct Formulations 9/8/2023

   Review a showcase of a high throughput robust analysis for nucleic acid integrity and size assessment of mRNA-LNP samples using a multi-capillary system and purity and integrity analysis kit.

3. Molecular Weight Confirmation For Length, Integrity And Impurity Analysis Of A 70-Mer Oligonucleotide 9/8/2023

   Explore a workflow used to determine the molecular weight and analyze the purity of a 70-mer DNA sequence with a 3’ dT overhang.

4. Assessment Of Product Quality In Upstream Process Development 9/7/2023

   Simplify your capillary electrophoresis sodium dodecyl sulfate and imaged capillary isoelectric focusing workflows with an automated platform for analyzing protein size and charge during development. 

5. A Guide To Adherent Scale-Up 9/5/2023

   Biomanufacturers looking to take advantage of the ongoing biomedical revolution and new treatments can benefit from platform solutions utilized in scaling-up adherent cell cultures.

6. Structural Characterization Of The Cationic LNP Component 8/31/2023

   Gain a deeper understanding of how EAD is used when characterizing ALC-0315 and its impurities, as well as identify the nature and site of chemical alterations in ALC-0315 resulting from forced degradation.

7. Characterization And Relative Quantification Of mRNA 5’-Capping 8/31/2023

   Review the development of an LC-MS method for the reliable identification and relative quantification of different mRNA capping structures.

8. Distinguishing Oxidative Impurities From Ionizable Lipids Used In LNP Formulations 8/31/2023

   A test conducts on a novel fragmentation mode for the detailed characterization of lipids, reveals information that can be used to determine drug efficacy and safety from formulated LNPs.

9. Comprehensive Peptide Mapping Of Protein Therapeutics 8/31/2023

   Explore how the peptide mapping workflows templates provided by a software designed for the characterization of biotherapeutic digests alongside data visualization and interrogation.

10. Alternative To A Three-Step Monoclonal Antibody Purification Process 8/30/2023

    Reduce the number of chromatography steps you are taking in your monoclonal antibody purification process by implementing a mixed-mode chromatography approach.