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Common Manufacturing Challenges For LBP Formulations

As more companies explore live biotherapeutic products, ensuring stability is likely to be front and center with unique challenges for oral and topical applications.

EDITOR'S DESK

2025 Cell Therapy Outlook From BPI West
Bioprocess Online and Cell & Gene spoke with Takeda’s Amy Shaw at BPI West to discuss the industry and her key takeaways from the conference.

Using AI And ML To Gain Insight Into Optimal Glycoforms

Bioprocess Online asked Nathan Lewis, Ph.D., to briefly explain the research he presented at BPI West 2025.

Impressions And Takeaways From BPI West 2025

Editor Tyler Menichiello reviews the most compelling topics and sessions from this year's BioProcess International U.S. West.

Areas For Advancement In Peptide Manufacturing

Experts from Eli Lilly, NervGen, and Piramal Pharma Solutions discuss the myriad of ways peptide manufacturing can be improved, drawing on years of industry experience and insight.

For Gilead, Sustainability Is More Than A PR Effort

Gilead's chief sustainability officer and SVP of operations, Joydeep Ganguly, explains the company's cultural focus on sustainability and how it influences everything from R&D to manufacturing.

GUEST COLUMNISTS

We Must Rethink The Solvents We Use For Peptide Synthesis
While the effectiveness of GLP-1 in weight loss is good news, the use of organic solvents in the GLP-1 synthesis and purification process is a growing pain that needs to be addressed.
Navigating Tariffs: Implications And Strategies For Pharmaceuticals Manufacturers
The U.S. tariffs on trading partners bring a whole new set of challenges, but there are tactics and strategies companies can deploy to help offset the cost and operational impacts.
Why You Need A Raw Material Control Strategy
You should start with the end goal in mind, but the first draft is almost never the last. These living documents should evolve as your team gains process knowledge.
Why Pharma Risk Assessments Should Include 'Working Together Alone'
When understood and managed properly, subjectivity becomes a source of creativity. It reveals hidden hazards and unlocks more effective risk controls.
Climbing The Blockchain Ladder To Optimize Clinical Supply Forecasting
Layering AI on top of blockchain technology offers a powerful way to predict kinks in the supply chain. Here's a look at where the technology is headed.
How CAR-NKs Offer Powerful Therapeutic Flexibility
Induced pluripotent stem cells have emerged as a promising platform for producing CAR-engineered NK cells in a standardized, renewable, and scalable way.
Ramping Up GMP-Compliant CAR-NK Manufacturing At Scale With iPSCs
The ability to produce billions of NK cells in a single production run represents a transformative shift in the economics and logistics of cell therapy.
Pharmaceutical Sovereignty: The Resilience We Cannot Outsource
Pharmaceutical sovereignty is no longer a theoretical concern. Sovereignty in this context does not imply isolation, but rather strategic resilience: building robust national and regional capabilities that ensure security while enabling global collaboration.

BIOPROCESSING WHITE PAPERS

Extractables And Leachables Testing
Learn how to navigate the extractables and leachables regulatory landscape and implement best practices for leachables analysis in your pharmaceutical development process.

Navigating Your Digital Journey To AI Success
11/2/2023

The first critical step in your digital journey, before implementing AI, is to ensure you’re at the right level of digital maturity.
From CLD To CDMO: Demonstrating A Successful Cell Line Technology Transfer
8/5/2024

Explore critical considerations for biopharmaceutical developers and CDMOs during technology transfer as well as a successful transfer and scale-up of a cell line from a CLD platform to a global CDMO.
The Benefits Of End-To-End Formulation And Fill/Finish Of Biologics
5/16/2024

Proper formulation development has a huge impact on whether a technology transfer to clinical phase fill/finish is successful. Review the challenges of transitioning a promising drug candidate.
Exploring Perfusion Technology For Virus Manufacturing Process Intensification
1/28/2025

Perfusion cell culture technology supports high cell densities and product yields for viral vaccine manufacturing, offering a reliable way to produce high-quality cells at a commercial scale.
Bioconjugates – An Increasing Diversity, A Blossoming Of Therapeutic Applications
10/24/2024

Harness the power of bioconjugation to revolutionize targeted therapies, enhance drug efficacy, and reduce side effects, paving the way for more precise and effective treatments across a range of diseases.

More Bioprocessing White Papers

BIOPROCESSING APP NOTES & CASE STUDIES

More Bioprocessing App Notes & Case Studies

BIOPROCESS ONLINE CONTENT COLLECTIONS

This collection of articles digs into the industry’s growing focus on knowledge management as an indispensable facet of biomanufacturing and pharmaceutical development, exploring how it plays into risk management, quality, vendor relationships, and supply chain resilience.