Purification Sourcing Center
Biologic purification is a critical series of downstream steps required to capture a target biomolecule and remove host cell related impurities, process related impurities, and product related impurities.
Those steps include protein extraction or isolation, purification, and polishing. The purification process generally exploits differences in protein size, biological activity, physicochemical properties, and binding affinity to produce specific, pure proteins. Whether at bench-scale or in a high-volume commercial production environment, the purification of biologic pharmaceutical products is complex and expensive, typically representing upwards of 50 percent of a therapeutic antibody’s downstream manufacturing cost, and often causing production bottlenecks. BioProcess Online offers a host of timely resources to help you manage the cost—and overcome the complexity—of the downstream purification process.
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3M Biopharmaceutical Purification
3M biopharmaceutical purification solutions work to optimize your processes, applying our biopharma experience, material science and proprietary technologies to help you develop highly effective purification solutions. Our solutions are designed for upstream and downstream processing. These solutions are focused on 3M innovative technologies for the development and manufacturing of recombinant proteins including mAbs, vaccines, and therapeutic plasma proteins.
Asahi Kasei Bioprocess America, Inc.
Asahi Kasei Bioprocess America, Inc. is dedicated to providing solutions to ensure safety, efficiency and purity for your therapeutic products within the bioprocess and pharmaceutical industries. We engineer fluid management equipment for Inline Buffer Formulation, Oligonucleotide Synthesis, Chromatography, Virus Filtration and more.
Your partner in bioprocessing.
Avantor’s bioprocessing solutions focus on what matters most for your operations. We provide a unique combination of industry expertise with the broadest portfolio of products and materials engineered and manufactured to satisfy the highest quality standards and regulatory requirements for your final product.
Bio-Rad Laboratories is a leading provider of innovative tools to the life science and clinical diagnostics markets, where the company’s products are used for scientific discovery, drug development, and biopharmaceutical production.
Bio-Techne empowers researchers in Life Science and Clinical Diagnostics by providing high-quality reagents instruments, custom manufacturing, and testing services. Whether you are at the cutting edge of academic research, translating basic discoveries to therapeutic leads, or at a facility that requires the highest level of diagnostic testing, our innovative products and services provide the solutions you need to achieve success.
Custom Sensors & Technology
Custom Sensors & Technology has been designing integrated process monitoring equipment and accessories for 40+ years. The PX2 and EZ-CAL technology is supplied with a qualification package that facilitates readable equipment and method validation. Additional services are available to ensure operational continuity to meet and exceed technical and compliance requirements. This cost-effective and integrated solution enables in-line real-time monitoring across biomanufacturing downstream unit operations across modalities.
Cygnus helps companies developing therapeutic proteins, vaccines, antibodies, plasma derivatives and gene therapies to ensure the safety of biotherapeutics prior to human trials, regulatory approval and commercial release. Cygnus provides analytical tools and solutions delivering insights to improve bioprocess development for faster regulatory approval and better clinical outcomes.
Cytiva provides the expertise and tools spanning a wide range of applications from basic research of proteins and cells to large-scale purification of biopharmaceuticals. Within the bioprocessing space, Cytiva provides products and expertise for developers and manufacturers of biotherapeutics.
JSR Life Sciences
JSR Life Sciences is a global built on more than 50 years of polymer expertise and began research in the life sciences more than 30 years ago. Using a variety of integrated, leading-edge technologies, JSR Life Sciences provides materials that contribute to the manufacturing process of biopharmaceuticals, life science research applications, in vitro diagnostics and medical devices.
At MilliporeSigma, our mission is to help our customers improve human health and life worldwide. This commitment means providing leading life science products and services in ways that also help improve the communities and environment in which we all live.
Pall’s leading-edge filtration, single-use systems, separation, purification and analytical technologies, as well as technical services in validation, assays and process optimization applicable to laboratory and pilot-scale development, play an essential role in the industry’s ability to manufacture these products. As an established global provider of analytical and purification technologies, Pall supports faster development of new drugs and vaccines around the world.
The Sartorius Group is a leading international partner of life science research and the biopharmaceutical industry. The Bioprocess Solutions Division with its broad product portfolio focusing on single-use solutions helps customers to manufacture biotech medications and vaccines safely and efficiently. The Group has been annually growing by double digits on average and has been regularly expanding its portfolio by acquisitions complementary technologies.
Thermo Fisher Scientific
To meet the increasing demand for biologics worldwide, you need to expect more from suppliers. It isn’t just about the products we deliver, but how we do business together. With a collaborative approach that is grounded in our technical knowledge, we work with you to achieve optimal bioprocessing outcomes.