Purification Sourcing Center
Biologic purification is a critical series of downstream steps required to capture a target biomolecule and remove host cell related impurities, process related impurities, and product related impurities.
Those steps include protein extraction or isolation, purification, and polishing. The purification process generally exploits differences in protein size, biological activity, physicochemical properties, and binding affinity to produce specific, pure proteins. Whether at bench-scale or in a high-volume commercial production environment, the purification of biologic pharmaceutical products is complex and expensive, typically representing upwards of 50 percent of a therapeutic antibody’s downstream manufacturing cost, and often causing production bottlenecks. BioProcess Online offers a host of timely resources to help you manage the cost—and overcome the complexity—of the downstream purification process.
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Asahi Kasei Bioprocess America, Inc.
Asahi Kasei Bioprocess America, Inc. is dedicated to providing solutions to ensure safety, efficiency and purity for your therapeutic products within the bioprocess and pharmaceutical industries. We engineer fluid management equipment for Inline Buffer Formulation, Oligonucleotide Synthesis, Chromatography, Virus Filtration and more.
Bio-Rad Laboratories is a leading provider of innovative tools to the life science and clinical diagnostics markets, where the company’s products are used for scientific discovery, drug development, and biopharmaceutical production.
Bio-Techne empowers researchers in Life Science and Clinical Diagnostics by providing high-quality reagents instruments, custom manufacturing, and testing services. Whether you are at the cutting edge of academic research, translating basic discoveries to therapeutic leads, or at a facility that requires the highest level of diagnostic testing, our innovative products and services provide the solutions you need to achieve success.
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CAI exists to help our customers design, deliver, operate, and maintain quality-critical manufacturing (GMP related) or mission-critical facilities. Our engineering, technical, and consulting services encompass all aspects of operation: equipment, automation, process, and human performance. The result is a superior level of operational performance and reliability.
Cygnus helps companies developing therapeutic proteins, vaccines, antibodies, plasma derivatives and gene therapies to ensure the safety of biotherapeutics prior to human trials, regulatory approval and commercial release. Cygnus provides analytical tools and solutions delivering insights to improve bioprocess development for faster regulatory approval and better clinical outcomes.
Cytiva provides the expertise and tools spanning a wide range of applications from basic research of proteins and cells to large-scale purification of biopharmaceuticals. Within the bioprocessing space, Cytiva provides products and expertise for developers and manufacturers of biotherapeutics.
Federal Equipment Company
Federal Equipment Company is a reliable resource for pharmaceutical processing and packaging equipment needs, with over 60 years of expertise working with manufacturers seeking to buy and sell used equipment.
JSR Life Sciences
JSR Life Sciences is a global built on more than 50 years of polymer expertise and began research in the life sciences more than 30 years ago. Using a variety of integrated, leading-edge technologies, JSR Life Sciences provides materials that contribute to the manufacturing process of biopharmaceuticals, life science research applications, in vitro diagnostics and medical devices.
At MilliporeSigma, our mission is to help our customers improve human health and life worldwide. This commitment means providing leading life science products and services in ways that also help improve the communities and environment in which we all live.
NanoTemper Technologies, Inc.
Our mission at NanoTemper Technologies is to create biophysical tools for scientists in drug discovery and development who need to tackle challenging characterizations. We build instruments that enable researchers everywhere to develop new and improved drug modalities – from small molecules to biologic therapeutics and AAVs– for a wide range of therapeutic areas.
Pall's leading-edge filtration, single-use systems, separation, purification and analytical technologies, as well as technical services in validation, assays and process optimization applicable to laboratory and pilot-scale development, play an essential role in the industry's ability to manufacture these products. As an established global provider of analytical and purification technologies, Pall supports faster development of new drugs and vaccines around the world.
Purolite, An Ecolab Company
Purolite® is a leading manufacturer of ion exchange, catalyst, adsorbent and advanced polymers. Headquartered in Bala Cynwyd, PA, the company has ISO 9001 certified manufacturing facilities in the USA, China, and Romania, and operates dedicated R&D centers in the USA, China, Romania, Russia, and the UK. Purolite is the only globally-acting company focused exclusively on resin technology with 40 sales offices in over 30 countries.
The Sartorius Group is a leading international partner of life science research and the biopharmaceutical industry. The Bioprocess Solutions Division with its broad product portfolio focusing on single-use solutions helps customers to manufacture biotech medications and vaccines safely and efficiently. The Group has been annually growing by double digits on average and has been regularly expanding its portfolio by acquisitions complementary technologies.
At SCIEX, our mission is to deliver solutions for the precision detection and quantification of molecules, empowering our customers to protect and advance the wellness and safety of all.
SCIEX has led the field of mass spectrometry for 50 years. From the moment we launched the first ever commercially successful triple quad in 1981, we have developed groundbreaking technologies and solutions that influence life-changing research and outcomes.
Thermo Fisher Scientific
To meet the increasing demand for biologics worldwide, you need to expect more from suppliers. It isn’t just about the products we deliver, but how we do business together. With a collaborative approach that is grounded in our technical knowledge, we work with you to achieve optimal bioprocessing outcomes.
W.L. Gore & Associates
GORE Protein Capture Devices with Protein A utilize a unique membrane solution that provides a binding capacity advantage at high flow rates and improves the speed of purification versus traditional technologies. The GORE Protein Capture Device scales across sizes without compromising binding capacity or speed and is available is sizes for early drug discovery screening, late stage optimization, process development, and GMP clinical applications.
Waters Corporation unlocks the potential of science through analytical measurement technology, deep scientific expertise, and reliable insights to enhance human health and well-being. As a global leader in analytical instruments, consumables, and software, Waters has pioneered chromatography, mass spectrometry, and thermal analysis innovations serving the life, materials, and food sciences for more than 60 years.