
ABOUT MILLIPORESIGMA
The life science business of Merck KGaA, Darmstadt, Germany brings together the world-class products and services, innovative capabilities and exceptional talent of EMD Millipore and Sigma-Aldrich to create a global leader in the life science industry.
At MilliporeSigma, our mission is to help our customers improve human health and life worldwide. This commitment means providing leading life science products and services in ways that also help improve the communities and environment in which we all live.
We re-imagine a future in which:
- Access to health and clean water is available to everyone around the world;
- Life science products not only advance human health, but also help restore and preserve our world; and
- Companies work in harmony with their communities to improve human lives.
We aren’t just re-imagining this future. We are working towards it every day. We invite you to learn more about our leadership commitment and our approach to corporate responsibility, as well as our goals and accomplishments for future-forward products, streamlined operations, and inspired people within and outside of our company.
VIDEOS
HOT PRODUCTS
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Designed to purify biologics at clinical and process scale, the Mobius® FlexReady Solution with Smart Flexware® Assemblies is flexible, allowing you to have a single system for tangential flow filtration (TFF) at various scales.
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Bio4C™ Orchestrator connects to individual unit operations from a centralized “orchestration layer” for complete visibility, monitoring, and management of regulatory-compliant biomanufacturing systems and processes. Bio4C™ Orchestrator’s consolidated control optimizes processes improving quality and compliance while reducing human errors and operating costs.
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To ensure optimum equipment uptime and regulatory compliance while mitigating risks, MilliporeSigma has developed System Service Reliance Plans; a complete range of services for your systems and equipment. These comprehensive service and support packages allow you to select a coverage level that best fit your needs
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MilliporeSigma’s Mobius® single-use mixing solutions deliver advanced technology for mixing pharmaceutical ingredients from intermediate to final drug products and for the preparation of process solutions, such as buffers and media. Unlike traditional stainless-steel mixers, single-use mixers reduce downtime due to CIP, SIP, cleaning validation, and process engineering. Mobius® single-use mixing solutions also offer operational flexibility as they can be up and running in less than five minutes. They are capable of mixing speeds up to 1000 RPMs meeting the broadest range of mixing production requirements. Mobius® flexibility offers you a choice of just the right filter, connector, tubing options for your specific application and environment, including sterile interfaces, from fermentation to final fill. Sizes range from 10 L to 3000 L.
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You’re developing lifesaving gene-modified cell therapies and need to manufacture lentiviral vector as quickly as possible. But scale-up and regulatory hurdles make the path to the clinic slow and labor intensive.
We're here to help.
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From your bioreactor to final sterile filtration, the new NovaSeptum® GO sampling system lets you sample processes the way you want. Flexible formats and volumes adapt to your process for robust, reliable monitoring and quality assurance.
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Cell culture media are important for process efficiency and mAb quality. Production media support initial cell growth and production, while the feeds replenish depleted nutrients required for cellular function and maintain and extend the production phase in fed-batch mode.
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Cellvento® CHO media are designed to support growth and maintenance of specific CHO cell lines in suspension cell culture for expression of monoclonal antibodies and recombinant proteins. The new Cellvento® 4CHO-X Expansion Medium supports cell expansion including N-1 perfusion for Chinese Hamster Ovary (CHO) cell lines.
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In recent years, the development of media used to expand and mature adult stem cells has greatly increased the success rate of adult stem cell therapy and the breadth of potential stem cell-based therapies. To obtain enough cells, ex vivo expansion has been utilized to ensure successful engraftment and economize the manufacture of both allogeneic and autologous therapies.
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Bio4C ProcessPad™ software is a data collection, visualization, and analytics software platform that facilitates 21 CFR Part 11 compliance and enables bioprocess monitoring, lifecycle management, reporting, investigations, and continued process verification (CPV).
BROCHURES
- Mobius® Essential Assemblies Specifications
- Innovative Single-Use Tangential Flow Filtration (TFF) Devices
- Single-Use Tangential Flow Filtration Solution
- Supel™ BioSPME 96-Pin Devices
- Lab Efficiency Calculator
- Chiral HPLC Columns For Chiral HPLC And LC-MS Separations
- Monkeypox Oligos - Primers & Probes For Research & Commercial Use
- Optimize Your Contamination Control Strategy
- Comprehensive Solutions For Your Vaccine Platforms
- Pellicon® Capsules With Ultracel® Membrane Performance Guide
WEBINARS AND PODCASTS
PRODUCT GUIDES, DATA SHEETS & APPLICATION NOTES
- Implementing High Cell Density Cryopreservation In Your Seed Train
- Innovative Single-Use Tangential Flow Filtration (TFF) Devices
- How Membrane Prefilters Enhance Bioprocessing Efficiency
- Single-Use Tangential Flow Filtration Solution
- Impact Of DMSO And Freezing Technique In Upstream Bioprocessing
- Implementation Of Raman Spectroscopy For In-Line Monitoring
- HPLC Columns Selection Guide
- Middle-Up Mass Analysis Of Protease Digested Cetuximab
- UHPLC Analysis of Vitamin D2 & D3
- LC-MS Resource Guide
NEWS
- MilliporeSigma Announces Support Of SaudiVax In Becoming First Developer And Manufacturer Of Halal Vaccines And Biotherapeutics In Saudi Arabia
- MilliporeSigma To Manufacture Next-Generation Biotherapeutics For Alteogen
- MilliporeSigma Announces Organizational Transformation To Strengthen CDMO Offering And Accelerate Future Growth
- MilliporeSigma’s Bio4C Orchestrator™ Software Optimizes Processes, Improves Compliance And Time To Market
- MilliporeSigma’s Latest Technologies Earn Industry Recognition For Accelerating Bioprocessing 4.0
- MilliporeSigma Advances Bioprocessing Capabilities With Raman Technology Sensor Acquisition
- MilliporeSigma Accelerates Readiness Of Bioprocessing Facility Of The Future
- MilliporeSigma Boosts Commercial Viral Vector And Gene Therapy Manufacturing Capacity
CONTACT INFORMATION
MilliporeSigma
400 Summit Drive
Burlington, MA 01803
UNITED STATES
Phone: 1-800-645-5476
NAVIGATING THE EMERGING BIOTECH ECOSYSTEM
- Navigate The Path To Commercialization For Biotech Start-Ups
- Regulatory, Funding And Outsourcing Best Practices For Biotech Start-ups
- Biotech Start-up Welcome Kit For Bioprocessing
- Pathways For Pioneers: Biopharmaceutical Start-Up Path To Commercialization
- Integrated Bioprocessing For Biotech Start-ups
FEATURED ARTICLES
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Simplify your seed train intensification with high cell density cryopreservation (HCDC). Eliminate the need for time-consuming manual scale-up steps and enable risk reduction through closed banking and inoculation processes.
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Regulatory guidance provides a framework for aseptic processing that ensures patient safety. Learn about the best practices for validating performance of critical filtration systems used in aseptic processing.
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The traditional seed train expansion process can be time consuming. Learn how seed train intensification techniques such as high cell density cryopreservation (HCDC) can accelerate and streamline the process.
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Explore integrating high cell density cryopreservation (HCDC) and how it can intensify your upstream process by increasing efficiency and productivity and reducing timelines and contamination risks.
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As the demand for new vaccines and therapeutics increases, so does the demand for raw materials, single-use technologies, and flexible manufacturing. Explore supply challenges and a robust qualification process.
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Explore studies that highlight the benefits of prefiltration for increasing throughput capacity of sterilizing-grade filters challenged with streams containing a wide range of particle size distributions.
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From fermentation to formulation, mRNA manufacturing requires a toolbox of technologies, services, and expertise. Explore our portfolio of solutions for making, purifying, and formulating mRNA.
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Integrating high cell density cryopreservation (HCDC) in the seed train means considering parameters like the choice of cryoprotectant and freezing technique.
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Explore the development and implementation of Raman spectroscopy-based soft sensors for process monitoring of CPPs in bench scale, CHO cell, intensified seed trains (N-1).
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Learn how we simplify bringing life-changing molecules to market, from pre-clinical to commercial, with our CTDMO services designed to support global clients.
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Explore a complete workflow of a middle-up mass analysis of protease digested Cetuximab mAb, starting with the antibody purification, proteolysis, and reduction to its reversed phase UHPLC-MS analysis.
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Explore the results of using a carbon LC column to separate vitamin D2 and D3 and their metabolites and epimers.
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What must we do as an industry to continue the momentum of cell and gene therapies and ensure these revolutionary treatments become a reality for patients who need them?
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AAV capsids have the potential to impact safety and efficacy. Here we learn more about the results generated from an internal study using AAV8 capsids.
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View the results generated from an internal study where peptide mapping of two different AAV serotypes – AAV8 and AAV9 – was performed by LC-MS.
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We review a protocol for heat stressing and SEC-UV analysis of monoclonal antibody aggregates and fragments.
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Learn more about manufacturing principles of LV vectors, and testing requirement regulatory considerations with a particular focus on the replication competent virus assay and infectious titer assay.
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MilliporeSigma experts and biomanufacturers discuss the importance of integration, collaboration, and education to address the industry paradigm shift towards novel modalities, continuous bioprocessing, and better risk mitigation.
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Learn more about the implementation of a raman spectroscopy platform and the way to accelerate the adoption of this technology as illustrated in this presentation with different use cases.
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Learn more about a successful strategy for increasing supply security through improving the resilience of manufacturing operations.