FEATURED ARTICLES

• Implementing High Cell Density Cryopreservation In Your Seed Train

  Simplify your seed train intensification with high cell density cryopreservation (HCDC). Eliminate the need for time-consuming manual scale-up steps and enable risk reduction through closed banking and inoculation processes.

• Validation Master Plan For Filtration Systems Used In Aseptic Processing

  Regulatory guidance provides a framework for aseptic processing that ensures patient safety. Learn about the best practices for validating performance of critical filtration systems used in aseptic processing.

• Using High Cell Density Cryopreservation For Seed Train Intensification

  The traditional seed train expansion process can be time consuming. Learn how seed train intensification techniques such as high cell density cryopreservation (HCDC) can accelerate and streamline the process.

• Optimizing DMSO Concentration And Freezing Technique For High Cell Density Cryopreservation In Upstream Bioprocessing

  Explore integrating high cell density cryopreservation (HCDC) and how it can intensify your upstream process by increasing efficiency and productivity and reducing timelines and contamination risks.

• Strategies To Address Supply Constraints Related To Sterilization

  As the demand for new vaccines and therapeutics increases, so does the demand for raw materials, single-use technologies, and flexible manufacturing. Explore supply challenges and a robust qualification process.

• How Membrane Prefilters Enhance Bioprocessing Efficiency

  Explore studies that highlight the benefits of prefiltration for increasing throughput capacity of sterilizing-grade filters challenged with streams containing a wide range of particle size distributions.

• mRNA Manufacturing And Formulation

  From fermentation to formulation, mRNA manufacturing requires a toolbox of technologies, services, and expertise. Explore our portfolio of solutions for making, purifying, and formulating mRNA.

• Impact Of DMSO And Freezing Technique In Upstream Bioprocessing

  Integrating high cell density cryopreservation (HCDC) in the seed train means considering parameters like the choice of cryoprotectant and freezing technique.

• Implementation Of Raman Spectroscopy For In-Line Monitoring

  Explore the development and implementation of Raman spectroscopy-based soft sensors for process monitoring of CPPs in bench scale, CHO cell, intensified seed trains (N-1).

• Millipore® CTDMO Services: The Industry’s Experienced Choice

  Learn how we simplify bringing life-changing molecules to market, from pre-clinical to commercial, with our CTDMO services designed to support global clients.

• Middle-Up Mass Analysis Of Protease Digested Cetuximab

  Explore a complete workflow of a middle-up mass analysis of protease digested Cetuximab mAb, starting with the antibody purification, proteolysis, and reduction to its reversed phase UHPLC-MS analysis.

• UHPLC Analysis of Vitamin D2 & D3

  Explore the results of using a carbon LC column to separate vitamin D2 and D3 and their metabolites and epimers.

• Viral Vectors: Are We There Yet?

  What must we do as an industry to continue the momentum of cell and gene therapies and ensure these revolutionary treatments become a reality for patients who need them?

• Empty/Full Capsid Ratio Of AAV By Sedimentation Velocity – Analytical Ultracentrifugation

  AAV capsids have the potential to impact safety and efficacy. Here we learn more about the results generated from an internal study using AAV8 capsids.

• Peptide Mapping Of AAV By LC-MS

  View the results generated from an internal study where peptide mapping of two different AAV serotypes – AAV8 and AAV9 – was performed by LC-MS.

• Workflow For Antibody Aggregate And Fragment Analysis

  We review a protocol for heat stressing and SEC-UV analysis of monoclonal antibody aggregates and fragments.

• Biosafety Testing And Quality Control Requirements For Lentiviral Vectors

  Learn more about manufacturing principles of LV vectors, and testing requirement regulatory considerations with  a particular focus on the replication competent virus assay and infectious titer assay.

• Solve Life Sciences Development Challenges With A Global Network Of Collaboration Spaces

  MilliporeSigma experts and biomanufacturers discuss the importance of integration, collaboration, and education to address the industry paradigm shift towards novel modalities, continuous bioprocessing, and better risk mitigation.

• Automation Across Upstream Processes With Raman Spectroscopy

  Learn more about the implementation of a raman spectroscopy platform and the way to accelerate the adoption of this technology as illustrated in this presentation with different use cases.

• Strengthening The Drug Manufacturing Supply Chain During Extraordinary Times

  Learn more about a successful strategy for increasing supply security through improving the resilience of manufacturing operations.