ABOUT MILLIPORESIGMA

The life science business of Merck KGaA, Darmstadt, Germany brings together the world-class products and services, innovative capabilities and exceptional talent of EMD Millipore and Sigma-Aldrich to create a global leader in the life science industry.

At MilliporeSigma, our mission is to help our customers improve human health and life worldwide. This commitment means providing leading life science products and services in ways that also help improve the communities and environment in which we all live.

We re-imagine a future in which:

  • Access to health and clean water is available to everyone around the world;
  • Life science products not only advance human health, but also help restore and preserve our world; and
  • Companies work in harmony with their communities to improve human lives.

We aren’t just re-imagining this future. We are working towards it every day. We invite you to learn more about our leadership commitment and our approach to corporate responsibility, as well as our goals and accomplishments for future-forward products, streamlined operations, and inspired people within and outside of our company.


TOOLS

Chromatography Volume and Flow Rate Calculator

WEBINARS

Using Single-Use Technology To Enable Single-Pass Tangential Flow Filtration Using Single-Use Technology To Enable Single-Pass Tangential Flow Filtration

As the industry is looking to increase speed to market, reduce manufacturing resources and increase product safety, there has been a push to implement single-use technologies. Combining both SPTFF and single-use technology can be a powerful tool for the efficient manufacture of biologics.

Filter Integrity Testing Best Practices Filter Integrity Testing Best Practices

Where sterility will be claimed, regulatory agencies worldwide require that the integrity of sterilizing-grade filter(s) is verified before and after use to ensure filter performance. This webinar highlights best practices and key considerations for performing filter integrity tests to give you a better understanding of how to design a robust integrity test operation in your own facility.

Strategies To Address Bioburden Control In Downstream Processing Strategies To Address Bioburden Control In Downstream Processing

Understanding the source, options for control, and potential impact of bioburden throughout downstream biopharmaceutical processes is beneficial to process developers, production operators and pharmaceutical microbiologists. Process designs that reduce the risks of bioburden contamination will decrease process related failures and the resulting painful, time-consuming investigations.

Scale-up Of High-Area Filters For Microfiltration Of Biological Fluids Scale-up Of High-Area Filters For Microfiltration Of Biological Fluids

In this webinar a M-pleat pattern is demonstrated to provide up to 100% more membrane area than a conventional pleat pattern.

Parvovirus Retentive Filter Spiking Study Best Practices Parvovirus Retentive Filter Spiking Study Best Practices

Parvovirus retentive filters are a commonly implemented and validated viral clearance technology within bioprocesses (mAb/recombinant and plasma fractionation). Regulatory guidance stresses that viral clearance filter validations be as representative of full scale manufacturing as possible to ensure the validity of the study results. There are a number of critical factors to consider during validation which can present challenges in maintaining this representativeness. If these factors are not properly addressed in the study design, retention and/or capacity could be negatively impacted.

Viral Clearance With Viresolve® Pro Solution  Prefiltration Strategies For Optimizing Performance Viral Clearance With Viresolve® Pro Solution Prefiltration Strategies For Optimizing Performance

Having challenges optimizing your virus clearance filter capacity and flux? Join us for our upcoming webinar to learn how prefiltration technologies can provide significant increases in the performance of your viral clearance filter.

Tech Transfer And Scale-Up – Tips And Tricks From A Biodevelopment Center Tech Transfer And Scale-Up – Tips And Tricks From A Biodevelopment Center

This presentation covers points to consider for successful tech transfers, and includes lessons learned from real cases.

Rapid Methodologies For Biosafety Testing Of Biologic Therapeutics Rapid Methodologies For Biosafety Testing Of Biologic Therapeutics

This webinar explores how rapid methodologies are being used to not only accelerate this process, but also enhance quality by reducing testing complexity.

Current Regulatory Expectations And Technical Advances In The Quality Control Of Biological Medicinal Products Current Regulatory Expectations And Technical Advances In The Quality Control Of Biological Medicinal Products

This webinar describes a number of topics in the areas of cell line characterization and bulk harvest testing for contaminants where new technical innovations are occurring. The regulatory response to these developments is also discussed.

Use Nanofiltration To Prevent Virus Contamination Of Cell Culture Processes Use Nanofiltration To Prevent Virus Contamination Of Cell Culture Processes

The Viresolve® Barrier filter offers opportunities for efficient processing of cell culture media components to reduce the risk of bioreactor contamination.

VIDEOS

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CONTACT INFORMATION

MilliporeSigma

290 Concord Road

Billerica, MA 01821

UNITED STATES

Phone: 781-533-6000

HOT PRODUCTS

  • Millipore Express® SHC Hydrophilic Filters
    Millipore Express® SHC Hydrophilic Filters

    Millipore Express® SHC (Sterile, High Capacity) filters provide superior throughput and capacity in applications where sterilizing-grade performance is needed and premature filter plugging is a concern. These filters are ideal for sterile filtration of cell culture media, protein solutions and other high fouling fluids. Millipore Express® SHC filters contain two polyethersulfone membrane layers, 0.5 μm/0.2 μm, and come in a range of device formats and sizes to suit your application needs.

  • Single-Use Mixer For Difficult-To-Mix Biopharm Ingredients
    Single-Use Mixer For Difficult-To-Mix Biopharm Ingredients

    MilliporeSigma’s Mobius® Power MIX 2000 single-use mixing system is engineered with advanced technology to effectively handle difficult-to-mix buffers, culture media powders and other pharmaceutical ingredients. The Mobius® Power MIX achieves a strong vortex using an impeller design and motor based on magnetically-coupled NovAseptic® technology, a proven mixing technology in stainless steel tanks. The Power MIX 2000 provides accessible, sterile zero deadleg sampling directly from the mixing container. A Probe Port allows for insertion of either a reusable probe for non-aseptic processes or a pre-sterilized, single-use sensor for in-process pH measurement of aseptic processes. Other design features make the mixing system easy to use, enabling loading of bags by one person and offering an optional integrated hoist for powder delivery.

  • Biodevelopment Services: From Molecule To Commercial Production
    Biodevelopment Services: From Molecule To Commercial Production

    Are you looking to expand the production of your recombinant proteins, vaccines or plasma commercial drugs? Do you need to bring affordable biosimilars to emerging markets?

  • Intelligent Virus Defense: Centinel
    Intelligent Virus Defense: Centinel

    Viral Resistance For The Future.
    Centinel™ technology goes beyond viral insurance. It’s an integral component of a sophisticated virus mitigation strategy for preventing, detecting and removing viruses.

  • Virus Safety Solutions: Viresolve®
    Virus Safety Solutions: Viresolve®

    The next generation parvovirus safety solution designed to provide the highest levels of retention assurance and productivity.

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