FEATURED ARTICLES

• Modeling The Economics Of Vaccine Manufacturing

  Here, we describe the use of a custom-designed cost model to explore the economics of vaccine manufacturing when using different modalities.

• Single-Use Multi-Layer Film Delivers Comparable Cell Growth Performance To Glass

  Explore the findings of studies analyzing the performance of upstream bioprocessing with Ultimus^® film, a single-use, multi-layer film with a fluid contact layer free of Irgafos^® 168.

• Prevent Costly Bag Leaks In Single-Use Manufacturing

  In the biopharmaceutical industry, bag leaks remain a top pain point for customers. Ultimus® film addresses this costly issue, offering superior protection against leaks, abrasions, tears, and material fatigue.

• Demonstrated Strength And Durability Of Ultimus® Film

  Here, we outline the development of Ultimus^® film and summarize the strength and robustness tests conducted in accordance with the American Society for Testing and Materials (ASTM).

• How Data Analytics Accelerates Transition To Bioprocessing 4.0

  Following successful Industry 4.0 implementation in the automotive, communications, aerospace, and other industries, the biopharma industry is now joining the digital revolution.

• Application Of A Sf-Rhabdovirus-Negative Platform For AAV Production

  Discover a two-part system comprising a proven Sf-9 cell line devoid of Sf-rhabdovirus and a chemically defined medium engineered for it. Explore performances of this medium for AAV2 production.

• mRNA Process And Cost Modeling: A Tool To Optimize Process Development

  Demand for mRNA-based medicine production continues to increase, as do investments in prophylactic and therapeutic indications. Explore a cost-model that compares all modalities.

• Applying High Throughput Processes To Optimize AAV Titers

  A growing number of AAV product developers are recognizing the value in moving to suspension as early in development as possible in order to optimize production.

• Viral Safety Handbook

  Since production templates depend on cell culture processes, biopharmaceuticals are susceptible to adventitious agent contamination. Explore a holistic overview of viral safety consolidating decades of expertise and process understanding.

• Chromatography Solutions For AAV Full And Empty Capsid Separation

  Effective separation of full and empty AAV capsids requires implementation of purification strategies that differ from standard approaches used for traditional modalities. Explore two cases describing such approaches.

• Performing A Tangential Flow Filtration (TFF) Optimization Study

  This application note describes the recommended methods and techniques for optimizing a tangential flow filtration (TFF) process using a Cogent® Lab system and the Bio4C® Control Software.

• Implementing High Cell Density Cryopreservation In Your Seed Train

  Simplify seed train intensification with high cell density cryopreservation. Eliminate the need for manual scale-up steps and enable risk reduction through closed banking and inoculation processes.

• Validation Master Plan For Filtration Systems Used In Aseptic Processing

  Regulatory guidance provides a framework for aseptic processing that ensures patient safety. Learn about the best practices for validating performance of critical filtration systems used in aseptic processing.

• Capsules Versus Hollow Fibers For Ultrafiltration/Diafiltration (UF/DF)

  Explore the performance evaluation of a first-of-its-kind spiral-wound TFF filter versus hollow fibers for UF/DF of viral vectors and the impact of either filter type on a TFF process.

• Biopharma 4.0: Convergence Of Information, Operations, And Processing Tech

  Biomanufacturers seeking a place in a competitive and lucrative future must start engaging in change now to meet the demands for delivering drugs more quickly to the patients who need them.

• Using High Cell Density Cryopreservation For Seed Train Intensification

  The traditional seed train expansion process can be time consuming. Learn how seed train intensification techniques such as high cell density cryopreservation (HCDC) can accelerate and streamline the process.

• Optimizing DMSO Concentration And Freezing Technique For High Cell Density Cryopreservation In Upstream Bioprocessing

  Explore integrating high cell density cryopreservation (HCDC) and how it can intensify your upstream process by increasing efficiency and productivity and reducing timelines and contamination risks.

• Strategies To Address Supply Constraints Related To Sterilization

  As the demand for new vaccines and therapeutics increases, so does the demand for raw materials, single-use technologies, and flexible manufacturing. Explore supply challenges and a robust qualification process.

• How Membrane Prefilters Enhance Bioprocessing Efficiency

  Explore studies that highlight the benefits of prefiltration for increasing throughput capacity of sterilizing-grade filters challenged with streams containing a wide range of particle size distributions.

• mRNA Manufacturing And Formulation

  From fermentation to formulation, mRNA manufacturing requires a toolbox of technologies, services, and expertise. Explore our portfolio of solutions for making, purifying, and formulating mRNA.