
ABOUT MILLIPORESIGMA
The life science business of Merck KGaA, Darmstadt, Germany brings together the world-class products and services, innovative capabilities and exceptional talent of EMD Millipore and Sigma-Aldrich to create a global leader in the life science industry.
At MilliporeSigma, our mission is to help our customers improve human health and life worldwide. This commitment means providing leading life science products and services in ways that also help improve the communities and environment in which we all live.
We re-imagine a future in which:
- Access to health and clean water is available to everyone around the world;
- Life science products not only advance human health, but also help restore and preserve our world; and
- Companies work in harmony with their communities to improve human lives.
We aren’t just re-imagining this future. We are working towards it every day. We invite you to learn more about our leadership commitment and our approach to corporate responsibility, as well as our goals and accomplishments for future-forward products, streamlined operations, and inspired people within and outside of our company.
VIDEOS
HOT PRODUCTS
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Designed to purify biologics at clinical and process scale, the Mobius® FlexReady Solution with Smart Flexware® Assemblies is flexible, allowing you to have a single system for tangential flow filtration (TFF) at various scales.
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Bio4C Orchestrator™ connects to individual unit operations from a centralized “orchestration layer” for complete visibility, monitoring, and management of regulatory-compliant biomanufacturing systems and processes. The software's consolidated control optimizes processes improving quality and compliance while reducing human errors and operating costs.
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To ensure optimum equipment uptime and regulatory compliance while mitigating risks, MilliporeSigma has developed System Service Reliance Plans; a complete range of services for your systems and equipment. These comprehensive service and support packages allow you to select a coverage level that best fit your needs
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MilliporeSigma’s Mobius® single-use mixing solutions deliver advanced technology for mixing pharmaceutical ingredients from intermediate to final drug products and for the preparation of process solutions, such as buffers and media. Unlike traditional stainless-steel mixers, single-use mixers reduce downtime due to CIP, SIP, cleaning validation, and process engineering. Mobius® single-use mixing solutions also offer operational flexibility as they can be up and running in less than five minutes. They are capable of mixing speeds up to 1000 RPMs meeting the broadest range of mixing production requirements. Mobius® flexibility offers you a choice of just the right filter, connector, tubing options for your specific application and environment, including sterile interfaces, from fermentation to final fill. Sizes range from 10 L to 3000 L.
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You’re developing lifesaving gene-modified cell therapies and need to manufacture lentiviral vector as quickly as possible. But scale-up and regulatory hurdles make the path to the clinic slow and labor intensive.
We're here to help.
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From your bioreactor to final sterile filtration, the new NovaSeptum® GO sampling system lets you sample processes the way you want. Flexible formats and volumes adapt to your process for robust, reliable monitoring and quality assurance.
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Cell culture media are important for process efficiency and mAb quality. Production media support initial cell growth and production, while the feeds replenish depleted nutrients required for cellular function and maintain and extend the production phase in fed-batch mode.
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Cellvento® CHO media are designed to support growth and maintenance of specific CHO cell lines in suspension cell culture for expression of monoclonal antibodies and recombinant proteins. The new Cellvento® 4CHO-X Expansion Medium supports cell expansion including N-1 perfusion for Chinese Hamster Ovary (CHO) cell lines.
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In recent years, the development of media used to expand and mature adult stem cells has greatly increased the success rate of adult stem cell therapy and the breadth of potential stem cell-based therapies. To obtain enough cells, ex vivo expansion has been utilized to ensure successful engraftment and economize the manufacture of both allogeneic and autologous therapies.
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Bio4C ProcessPad™ software is a data collection, visualization, and analytics software platform that facilitates 21 CFR Part 11 compliance and enables bioprocess monitoring, lifecycle management, reporting, investigations, and continued process verification (CPV).
BROCHURES
- Single-Use Film Engineered For Superior Strength And Leak Resistance
- M-Trace™ Software For Trusted And Efficient Data Recording
- Software To Automate And Digitalize Data Recording Steps In QC Workflows
- Solution For Rapid Sterility And Bioburden Testing
- Remote Control And Automation Software Optimized For Bioprocess
- Single-Use Sterile Sampling Assemblies
- M Lab™ Collaboration Centers
- Mobius® Essential Assemblies Specifications
- Innovative Single-Use Tangential Flow Filtration (TFF) Devices
- Single-Use Tangential Flow Filtration Solution
WEBINARS AND PODCASTS
PRODUCT GUIDES, DATA SHEETS & APPLICATION NOTES
- Demonstrated Strength And Durability Of Ultimus® Film
- Single-Use Film Engineered For Superior Strength And Leak Resistance
- Software To Automate And Digitalize Data Recording Steps In QC Workflows
- Solution For Rapid Sterility And Bioburden Testing
- Remote Control And Automation Software Optimized For Bioprocess
- Single-Use Sterile Sampling Assemblies
- Application Of A Sf-Rhabdovirus-Negative Platform For AAV Production
- Chromatography Solutions For AAV Full And Empty Capsid Separation
- Performing A Tangential Flow Filtration (TFF) Optimization Study
- Implementing High Cell Density Cryopreservation In Your Seed Train
NEWS
- MilliporeSigma Announces Support Of SaudiVax In Becoming First Developer And Manufacturer Of Halal Vaccines And Biotherapeutics In Saudi Arabia
- MilliporeSigma To Manufacture Next-Generation Biotherapeutics For Alteogen
- MilliporeSigma Announces Organizational Transformation To Strengthen CDMO Offering And Accelerate Future Growth
- MilliporeSigma’s Bio4C Orchestrator™ Software Optimizes Processes, Improves Compliance And Time To Market
- MilliporeSigma Advances Bioprocessing Capabilities With Raman Technology Sensor Acquisition
- MilliporeSigma Accelerates Readiness Of Bioprocessing Facility Of The Future
CONTACT INFORMATION
MilliporeSigma
400 Summit Drive
Burlington, MA 01803
UNITED STATES
Phone: 1-800-645-5476
NAVIGATING THE EMERGING BIOTECH ECOSYSTEM
FEATURED ARTICLES
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Here, we describe the use of a custom-designed cost model to explore the economics of vaccine manufacturing when using different modalities.
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Explore the findings of studies analyzing the performance of upstream bioprocessing with Ultimus® film, a single-use, multi-layer film with a fluid contact layer free of Irgafos® 168.
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In the biopharmaceutical industry, bag leaks remain a top pain point for customers. Ultimus® film addresses this costly issue, offering superior protection against leaks, abrasions, tears, and material fatigue.
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Here, we outline the development of Ultimus® film and summarize the strength and robustness tests conducted in accordance with the American Society for Testing and Materials (ASTM).
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Following successful Industry 4.0 implementation in the automotive, communications, aerospace, and other industries, the biopharma industry is now joining the digital revolution.
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Discover a two-part system comprising a proven Sf-9 cell line devoid of Sf-rhabdovirus and a chemically defined medium engineered for it. Explore performances of this medium for AAV2 production.
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Demand for mRNA-based medicine production continues to increase, as do investments in prophylactic and therapeutic indications. Explore a cost-model that compares all modalities.
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A growing number of AAV product developers are recognizing the value in moving to suspension as early in development as possible in order to optimize production.
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Since production templates depend on cell culture processes, biopharmaceuticals are susceptible to adventitious agent contamination. Explore a holistic overview of viral safety consolidating decades of expertise and process understanding.
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Effective separation of full and empty AAV capsids requires implementation of purification strategies that differ from standard approaches used for traditional modalities. Explore two cases describing such approaches.
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This application note describes the recommended methods and techniques for optimizing a tangential flow filtration (TFF) process using a Cogent® Lab system and the Bio4C® Control Software.
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Simplify seed train intensification with high cell density cryopreservation. Eliminate the need for manual scale-up steps and enable risk reduction through closed banking and inoculation processes.
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Regulatory guidance provides a framework for aseptic processing that ensures patient safety. Learn about the best practices for validating performance of critical filtration systems used in aseptic processing.
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Explore the performance evaluation of a first-of-its-kind spiral-wound TFF filter versus hollow fibers for UF/DF of viral vectors and the impact of either filter type on a TFF process.
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Biomanufacturers seeking a place in a competitive and lucrative future must start engaging in change now to meet the demands for delivering drugs more quickly to the patients who need them.
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The traditional seed train expansion process can be time consuming. Learn how seed train intensification techniques such as high cell density cryopreservation (HCDC) can accelerate and streamline the process.
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Explore integrating high cell density cryopreservation (HCDC) and how it can intensify your upstream process by increasing efficiency and productivity and reducing timelines and contamination risks.
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As the demand for new vaccines and therapeutics increases, so does the demand for raw materials, single-use technologies, and flexible manufacturing. Explore supply challenges and a robust qualification process.
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Explore studies that highlight the benefits of prefiltration for increasing throughput capacity of sterilizing-grade filters challenged with streams containing a wide range of particle size distributions.
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From fermentation to formulation, mRNA manufacturing requires a toolbox of technologies, services, and expertise. Explore our portfolio of solutions for making, purifying, and formulating mRNA.