FEATURED CONTENT

• Rapid Thermal Stability Screening And Selection Of Monoclonal Antibody Drug Products

  Learn more about a differential scanning calorimeter that offers thermal stability screening of buffer formulations and protein sequence modifications.

• Leveraging Innovative Analytics To Ensure The Thermal Stability Of mAb Drug Products

  Uncover how innovative Rapid Screening-Differential Scanning Calorimeter technology is enabling robust analysis and regulatory compliance by ensuring the thermal stability of antibody drug products.

• Rapid Thermal Stability Screening Of High Concentration Biologic Drugs

  Explore data demonstrating the effectiveness of a rapid screening-differential scanning calorimeter as well as its detection limits and the range of concentrations suitable for DSC analysis.

• Analysis Of Drug-Excipient Incompatibility In Discovery And Formulation Development

  We analyze drug-excipient incompatibility using a microcalorimeter system equipped with a multi-sample cell capable of simultaneously measuring highly sensitive heat flow data from up to three samples.

• Characterizing Virus Structure And Binding

  Here, we review applications of Nano DSC and ITC for studying the stability of virus particles and their binding to cells, as well as for the identification of viruses.

• Determining Thermal Stability Of Antibodies With A Nano DSC

  Explore the performance of an instrument with data analysis software capabilities that easily deconvolutes thermograms, enables differentiation between individual and interacting domains, and reports accurate Tm values.

• Considerations When Choosing A Baseline And Model

  Modeling DSC data can give additional insight into the macromolecule unfolding process or help to deconvolute a multiple transition thermogram. Explore guidelines for baseline and DSC model selection.

• Characterization Of Biopharmaceutical Stability

  Learn how a DSC thermogram was able to detect and quantify the differences in varying drug loads with respect to thermal parameters including Tm, Tonset, and enthalpy (ΔH).

• Advances In Native Binding Assays

  Isothermal titration calorimetry (ITC) is a technique where heat is measured under constant pressure. Explore advances that will enable investigators to expand their research using ITC.

• A Novel Thermodynamic Assay For Biomolecular Structure Stability

  This comparability study utilized a nano differential scanning calorimeter to detect biomolecular structure changes in response to subtle manipulations of liquid protein reference formulation.

• Isothermal Titration Calorimetry In Organic Solvent Systems

  Isothermal titration calorimetry is a powerful analytical tool to study molecular binding. Learn about the development of a representative binding assay that measures Ca2+ interactions with a calcium ionophore.

• Workflow Solutions: Choosing The Right ITC Binding Experiment

  Enthalpy screen, incremental titration, and continuous titration were utilized to characterize the binding of Furosemide and Carbonic Anhydrase II. See how these ITC methods compare in the experiment results.

• A New Approach To Characterizing Crystalline Structure

  Learn how the accuracy (melting temperature and heat of fusion) and utility of Differential Scanning Calorimetry data is greatly diminished for materials that undergo Apparent Melting and much more.

• A New Approach To Detecting Drug-Excipient Incompatibility

  Explore a systematic thermal analysis approach for detecting drug-excipient incompatibility. The proposed method uses the approach of apparent melting and provides a rapid screening protocol.

• Pharmaceutical Applications Of Isothermal Microcalorimetry

  Examine the most commonly used microcalorimetric techniques in pharma, including stability and compatibility tests, determination of small amounts of amorphic content, and characterizing polymorphism.