Insights On Upstream Manufacturing
-
Analyzing Serum-Free Media For Cell Therapy Applications
3/14/2024
Identifying critical factors and their concentrations with an eye towards designing an ideally formulated, defined serum-free medium should be carried out using rational and systematic approaches.
-
Metabolite Analysis In Cell Therapy Development
3/14/2024
Understand the importance of metabolic analysis in cell therapy, optimizing cell culture media formulations, and enhancing the effectiveness of CAR T-cell therapy and stem cell transplantation.
-
Enhancing AAV6 Vector Production For Cell Therapies
3/13/2024
For the robust manufacturing of the serotype AAV6, the Pro10™ production platform has proven reliability and scalability, making it suitable for meeting the demands of large-scale manufacturing.
-
A Robust Alternative To Plasmid DNA For AAV Production
3/13/2024
Review a comparison of side-by-side plasmids and neDNA™ for AAV production in the Pro10™ cell line, using different AAV capsid serotypes and productions scales.
-
A Mammalian Suspension Technology For Scalable rAAV Production
3/13/2024
Explore a HEK293 derived animal component-free suspension cell line as the foundation of an up to 2000-liters scalable and robust platform process that increases the speed of AAV manufacturing.
-
Idea To Clinic: Accelerate Your Manufacturing Timeline To FIH Studies
3/11/2024
Translating novel drug discoveries into clinical trials remains a complex endeavor. Learn how a CDMO with cutting-edge technologies can facilitate a smooth path from discovery to FIH studies.
-
A Century Of Cell Culture And The Rise Of Organ-Chips
3/8/2024
Despite its advantages in researching biological processes, 2D cell culture suffers from its artificial nature. Learn about 3D cell culture and how it is advancing in vitro studies.
-
In Vitro Vs In Vivo: A History Of Modern Cell Culture
3/8/2024
Explore the origins of modern cell culture as well as the advantages and disadvantages of in vitro and in vivo studies.
-
High-Titer rAAV Production In Bioreactors Using Producer Cell Lines
3/6/2024
Here, we detail the upstream process development and optimization for an AAV8-GFP proof-of-concept (PoC) producer single cell clone (SCC) in both batch and perfusion modes.
-
Producer Cell Line For Large-Scale Viral Vector Manufacturing
3/6/2024
Embrace the future of gene therapies and overcome challenges in large-scale viral vector manufacturing with a one-step process that ensures robustness and scalability.