Insights On Upstream Manufacturing

  1. Spatial Organization Of The CAR Is Critical For CAR T Cell Function 1/27/2026

    Explore how advanced single‑cell analysis links CAR localization, cell structure, and functional behavior, offering deeper insight into CAR T cell heterogeneity and performance.

  2. Exploring Perfusion Technology For Virus Manufacturing Process Intensification 1/23/2026

    Perfusion cell culture technology supports high cell densities and product yields for viral vaccine manufacturing, offering a reliable way to produce high-quality cells at a commercial scale.

  3. Next-Level Cell Lines: An Integrated Approach To Biologic Innovation 1/22/2026

    See how AI-driven tools and optimized platforms are accelerating biologics development, delivering high-titer clones in weeks, and paving the way for integrated design of cell lines and genetic systems.

  4. Disruptive Technologies Transforming Upstream Process Intensification 1/22/2026

    The demand for complex biologics is driving the need for intensified cell culture technologies. Perfusion using ATF has emerged as a leading solution to increase cell density and productivity.

  5. Solving Atypical Protein Expression With Transposases 1/21/2026

    To optimize productivity and avoid costly delays for complex proteins, researchers should leverage flexible platforms and experienced CDMOs in cell line development.

  6. Simpler, Faster, Cheaper Advanced Therapy Manufacturing 1/20/2026

    Discover how TFDF-based perfusion technology boosts lentiviral vector production by over 10-fold, slashes costs, and accelerates the commercialization of CAR-T and other advanced cell therapies.

  7. Accelerating The Seed Train: Enabling N-1 Intensification 1/15/2026

    Discover how N-1 intensification shortens production timelines and improves cell viability by replacing traditional filtration with automated, low-shear separation techniques to achieve higher seeding densities.

  8. Rebalancing mAb Clarification: From Depth Filter Dependence To Process Harmony 1/15/2026

    Learn how optimizing clarification workflows can reduce product loss and minimize buffer consumption by shifting primary workloads away from traditional high-capacity depth filtration systems.

  9. Modernizing Cell Banking: Scalable, Consistent, And Automated 1/15/2026

    Discover how automating cell banking workflows minimizes contamination risks and preserves viability in high-density cultures, ensuring consistent recovery and smoother scale-up.

  10. A Sustainable Future: Phasing Out Animal Testing 1/14/2026

    Discover a practical roadmap for replacing animal tests with advanced molecular methods, as well as how regulatory updates and innovative technologies are shaping a sustainable future.