Insights On Upstream Manufacturing

  1. Industrializing iPSC Feed Streams Via Critical Process Parameter And Raw Materials Optimization 8/6/2026

    Explore how an optimized bioprocess with purpose-designed medium and GMP-compatible reagents achieved 10,000-fold iPSC expansion in under two weeks while maintaining pluripotency and a weekend-free workflow.

  2. Advanced Analytical Profiling Of MSC-EVs: Tissue- And Donor-Dependent Heterogeneity 8/6/2026

    Tissue source and donor identity drive measurable differences in MSC-EV quality attributes. See how analytical profiling reveals what varies and why it matters for scalable manufacturing.

  3. A Unified Development Blueprint For Accelerating Timelines: DNA To DS Bulk Fill In 8.5 months 8/4/2026

    Learn how early integration of cell line engineering, process development, and analytics compressed a complex antibody program from DNA to drug substance bulk fill in just 8.5 months.

  4. How Modular Workflows Are Redefining CAR T Manufacturing 7/30/2026

    Learn how flexible modular workflows can help manufacturers improve process adaptability, throughput, and control while preserving key CAR T quality attributes, including transduction efficiency.

  5. The First On-Demand, Automated Solution For Powdered Media And Buffer Hydration 7/29/2026

    Discover how an automated, single-use hydration system cuts preparation time in half while delivering consistent, on-demand media and buffer solutions for bioprocessing operations.

  6. Cell Type Setting Considerations For Counting Clumpy Cells 7/29/2026

    Cell clumping can dramatically affect counting accuracy. Learn how declustering, mixing, and aspiration settings influence cell density measurements and help generate more reliable viability.

  7. Chemically Defined Medium For Intensified AAV And LV Production In HEK293 Cells 7/29/2026

    Discover how a chemically defined medium designed for suspension HEK293 perfusion cultures supports intensified AAV and LV production processes, with viable cell densities exceeding 10^8 cells/mL.

  8. Industry Highlights: Switching From Manual To Automated HSC Gene Engineering 7/28/2026

    See how automation can help make HSC gene therapy manufacturing more consistent, scalable, and efficient by reducing manual handling and improving key process outcomes such as transduction efficiency.

  9. Automated Manufacturing Of Tumor-Reactive T Cells 7/28/2026

    Discover how CD137-based enrichment improves glioblastoma TIL manufacturing by expanding reactive T cell populations, preserving unique clonotypes, and strengthening autologous tumor cell killing.

  10. Two-Step Selection Strategy Improves TIL Manufacturing From Cold Tumors 7/28/2026

    Learn how a refined two-step TIL selection workflow improves manufacturing from cold tumors by enriching tumor-reactive cells earlier, reducing exhausted phenotypes, and supporting stronger expansion.