Insights On Upstream Manufacturing

  1. Find The Right T Cell Expansion And Phenotype Balance For Cell Therapy 3/22/2024

    Explore this study that works to determine the optimal concentrations of IL-7 and IL-15 for T cell expansion, as well as how to produce the desired phenotype while requiring less protein.

  2. Touch-Free T Cell Expansion With A Fill-And-Forget Workflow 3/22/2024

    Explore a bioreactor for large-scale, low-cost immune cell therapy manufacturing paired with a "fill-and-forget" workflow and discover how robust T cell expansion can be achieved.

     

  3. XOFLX™ Lenti Platform: Stable Lentiviral Vector Production Cell Lines Yield LVV Titres Comparable To The Four-Plasmid Process 3/21/2024

    LVV manufacturing processes remain a significant hurdle for sponsors. Review the potential of a platform of packaging and producer cell lines designed to enhance LVV manufacturing efficiency.

  4. Development And Optimization Of Suspension-Adapted 293T Cell Line 3/21/2024

    Learn how an adapted cell line can reduce costs and improve scalability in the production of lentiviral vectors for CGTs and examine its potential to produce GMP-grade lentiviral vectors.

  5. Scale Up Strategy For Oncolytic HSV-1 Vector Manufacturing 3/21/2024

    Discover how a novel, large-scale production method for herpes simplex virus type-1 vectors has the potential to accelerate the progress of gene therapy and bring it closer to widespread application.

  6. Cell Line Development For High-Titer Lentivirus Vector Production 3/21/2024

    Explore a groundbreaking method to significantly enhance LV vector yield using engineered HEK293T cells. This approach paves the way for more efficient and large-scale production of LV vectors.

  7. A Launchpad For Scalable Systems In AAV Gene Therapy Manufacturing 3/21/2024

    Identifying a trusted supplier that can address the myriad of challenges that accompany development for AAV-based drugs is critical to securing an asset’s ultimate commercial success.

  8. Enhancing Quality By Employing Cell Line Replacement, Process Optimization 3/19/2024

    Explore how the various proprietary platforms and in-house expertise fit together to enable a range of comprehensive options that can be adapted to fit development strategies.

  9. GMP-Compliant Production Lines Of Plasmid 3/19/2024

    The OBiO Intelli-M GMP manufacturing site has three production lines of prokaryotic cell culture plasmid for commercial manufacturing, including a single-use whole process production line and two stainless steel production lines.

  10. A New Horizon In AAV cGMP Gene Therapy Manufacturing 3/18/2024

    For cell expansion to occur, we use the world-leading cell line: Pro10™ by AskBio. Viralgen is the only company in the world with a license to manufacture for third parties.