Insights On Upstream Manufacturing

31. An Alternative Genetic Engineering Tool In CHO Cells 8/15/2025

    Discover how transposon technology is being reimagined as a precise genetic engineering tool to create high-performing CHO cell lines for biotherapeutic production with enhanced metabolic and glycan profiles.

32. Developing An In Vivo CAR-T With Interius BioTherapeutics' Sianny Christanti and Babu Medi, Ph.D. 8/12/2025

    On this episode of Better Biopharma, Interius BioTherapeutics’ Sianny Christanti and Babu Medi, Ph.D., explain how the company is re-engineering a lentiviral vector to enable INT2104, its off-the-shelf, in vivo CAR T-cell therapy. They discuss the vector's design and its manufacturability, as well as the analytical and regulatory challenges of bringing this first-in-human therapy to the clinic.

33. Seed Train Intensification Using High Cell Density Cryopreservation 8/11/2025

    Streamline your upstream bioprocessing with seed train intensification. Discover how high cell density cryopreservation reduces scale-up time, boosts consistency, and enhances manufacturing flexibility.

34. Cell Retention Technology And Specialized Cell Culture Media 8/11/2025

    Explore how perfusion technology is transforming upstream bioprocessing by boosting productivity, reducing costs, and enabling process intensification while overcoming cell retention challenges.

35. Facts About AAV Producer Cell Lines 8/8/2025

    Gene therapies are revolutionizing medicine, with AAV vectors leading the way. As production evolves, stable cell lines may replace transient transfection and unlock scalable solutions.

36. Enhance Lab Productivity And Ensure Reliability: Shaking Incubator Proactive Service 8/7/2025

    Regular preventive maintenance is essential for ensuring the longevity and optimal performance of your shaking incubator. Find out how this approach helps avoid costly downtime and protects your research.

37. Bioconversion Of Babassu Mesocarp Flour Into Single-Cell Protein In A Controlled Bioreactor System 8/7/2025

    Discover how the continuous feeding of babassu hydrolysate to yeast cultures can efficiently transform a byproduct into a protein-rich ingredient for plant-based foods.

38. Optimized Expression Systems For Increased Productivity 8/7/2025

    Discover innovative strategies to boost CHO DG44 cell line productivity, as well as explore optimized expression systems that enhance yield, stability, and efficiency in protein development.

39. Expand Your Capabilities And Shorten Your Time-To-Clinic 8/7/2025

    Gain expert insights into cell line development for biologics commercialization. and learn how CLD services—from DNA to GMP Master Cell Bank—can accelerate your path to clinical success.

40. Reducing Risk, Decreasing Timelines, And Optimizing Outcomes 8/7/2025

    Explore the challenges of cell line development (CLD) in biologics commercialization and discover how integrated solutions can streamline your strategy, reduce risks, and optimize outcomes.