Insights On Upstream Manufacturing

  1. Optimize Every Step In Your Biopharma Site 7/5/2026

    Bridge the gap between validation and cleanroom execution. Learn how proactive site surveys, residue management, and robust CAPA programs resolve compliance deficiencies and ensure audit readiness.

  2. Streamline Fluid Disconnections And Reduce Tear-Down Complexity 7/5/2026

    Accelerate process turnover and fortify fluid line sterility without complex tools. Gain insight into how modern, metal-free connector geometries mitigate spillage and preserve cell viability.

  3. Advanced Adherent Corning Platforms For Scalable Viral Vaccine Manufacturing 7/5/2026

    Optimize vaccine production by balancing adherent cell line kinetics with advanced scaling methodologies. Learn to navigate cellular metabolism bottlenecks and implement perfusion strategies.

  4. Upstream Decisions Influence Downstream Challenges 7/1/2026

    In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), answer the question, “What should developers be thinking about upstream to avoid downstream complications?” Klyushnichenko believes process-wide considerations like this begin earlier than cell line development at the product’s molecular construct itself.

  5. Productivity Gains Upstream Apply Pressure Downstream 7/1/2026

    In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), reflect on the progress that’s been made in terms of productivity gains and the “ceiling” that mAbs face, and how these upstream gains stress downstream operations. They also discuss how molecular complexity relates to challenges in purification.

  6. Continuous Manufacturing As A Powerful Productivity Lever 7/1/2026

    In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), discuss the potential of perfusion and continuous manufacturing to improve productivity through smaller facility footprints and greater output over time. They also examine the challenges associated with these approaches, including cell-line stability, process monitoring, and the cost of operational mistakes.

  7. Next-Generation Molecules Challenge Notions Of Yield And Performance 7/1/2026

    In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), discuss how the process-related associated with next-generation molecules like bispecifics and trispecifics complicate downstream purification efforts impurities (e.g., chain mispairings). They agree that mitigating these impurities is a developmental challenge both upstream and downstream.

  8. Understanding Fixed Variables And Working Within Their Constraints 7/1/2026

    Some things are intrinsic, unchanging realities of a process — molecular complexity, product developability, and facility fit, to name a few. In this segment from the Bioprocess Online Live event, “The Levers And Tradeoffs That Drive Process Productivity,” panelists David Scherr, Ph.D. (AstraZeneca) and Vadim Klyushnichenko, Ph.D. (Calibr-Skaggs), discuss these “non-pullable levers” of process development and advise teams on how to work within their boundaries.

  9. Breaking the Titer Ceiling: Smarter Media Design for Higher Productivity 6/30/2026

    A bottom-up, data-driven media design approach shows how targeted nutrient optimization overcomes metabolic limits to boost culture performance and titer while maintaining product quality and process consistency.

  10. Is It Better To Scale Up Or Scale Out Your Cell Culture Platform? 6/29/2026

    Take a look at how adherent cell culture expansion affects space, labor, costs, contamination risk, and sustainability, helping teams weigh when a larger-footprint approach stops making sense.