Insights On Upstream Manufacturing

  1. Validation, PAT, And AI In Fed-Batch And Continuous Environments 5/16/2025

    During this segment of the Bioprocess Online Live event Process Optimization or Full-Scale Automation, David Bruehlmann, Ph.D. addresses audience questions on process analytical technology (PAT) validation, stressing the importance of process understanding before technology adoption. We also discuss AI’s value—and limitations—in current biopharmaceutical manufacturing environments.

  2. A Fed-Batch Chemically Defined hMSC-EV Bioprocess Medium Enabling 2-4x EV Yield Improvements In Bioreactor Culture 5/16/2025

    A new chemically defined fed-batch bioprocess medium simplifies hMSC-EV production, increasing yields by 2-4x while maintaining EV quality across donors and tissue types in scalable GMP-compatible environments.

  3. Successful Development Of A Scalable And Robust Process For MSC-EV Production 5/16/2025

    One of the challenges faced in EV production is scaling up manufacturing processes. Discover a reproducible and scalable microcarrier-based process for EV production in a stirred tank bioreactor system.

  4. Advanced Technology Platform For Stem Cell-Derived Exosomes 5/15/2025

    Demand for extracellular vesicles (EVs) is rising due to their therapeutic promise. Explore two scalable platforms that address production challenges to support EVs' expanding clinical and commercial applications.

  5. Extracellular Vesicle Isolation From Conditioned Media 5/15/2025

    Explore a scalable, sterile solution for isolating extracellular vesicles (EVs) in exosome therapeutics to enhance yield, purity, and commercial viability through innovative filtration technology.

  6. Viral Vector Manufacturing Using Tangential Flow Depth Filtration 5/15/2025

    Address the rising gene therapy demands with an innovative perfusion strategy that significantly boosts cell density and viral vector yields to pave the way for scalable, efficient manufacturing.

  7. PSC Perfusion Guidance Using Vertical-Wheel Bioreactors 5/9/2025

    Unlock the potential of perfusion for pluripotent stem cell cultures. Explore key insights into achieving improved consistency and quality in your medium exchange protocols, leading to better outcomes.

  8. The Role Of Peptones In Boosting Monoclonal Antibody Production 5/9/2025

    Peptones have become a key tool in CHO cell bioprocessing, enhancing monoclonal antibody yield and quality.

  9. Rapid Discovery Of CD200R1 Antagonist VHHs Via Single B Cell Technology 5/7/2025

    Here, we used single B cell antibody discovery to rapidly identify a diverse set of potent, high-affinity, neutralizing VHH from immunized llamas against CD200R1, an emerging therapeutic immune checkpoint target.

  10. Advanced mAb Process Intensification Strategies 5/6/2025

    Advancements in perfusion media, high-density cell banking, and downstream intensification are streamlining biologics manufacturing for greater efficiency and cost-effectiveness.