Insights On Upstream Manufacturing

  1. Take The Lead With The Gibco CHOvantage™ GS Cell Line Development Kit 3/13/2026

    See how this kit accelerates clone development to 14 weeks with ≥7 g/L protein titers while reducing costs through royalty-free commercial licensing for therapeutic applications.

  2. Extracellular Secretion Of Recombinant Proteins: Proof-Of-Principle Data 3/10/2026

    Explore experimental approaches to extracellular protein secretion that streamline recovery and improve product quality. See proof-of-principle data across multiple protein types and molecular weights.

  3. Extracellular Protein Secretion Into The Culture Media: A Lever In Microbial Expression 3/10/2026

    Explore how engineered microbial hosts enable extracellular protein secretion, bypassing lysis to deliver cleaner starting material and faster recovery across multiple therapeutic modalities.

  4. The Importance Of Process Locks To Align Upstream And Downstream 3/9/2026

    In this closing segment from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration,” the panelists emphasize the importance of periodic process locks to ensure alignment between upstream and downstream development teams. These locks are critical, says Eric Doerr, a manufacturing lead at Sanofi, because they allow both upstream and downstream to have a better understanding of the process and keep them on the same page.

  5. Feed Media Can Significantly Impact Process Performance 3/9/2026

    In this segment from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration,” our panelists respond to an audience question about feed media and its impact on process performance.

  6. Finding Ways To Reduce Process COGs Upstream And Downstream 3/9/2026

    In this segment from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration,” our panelists discuss where they see the greatest opportunities for teams to reduce COGs and advise teams to take a holistic approach to cost reduction.

  7. The Importance Of Upstream–Downstream Coordination 3/9/2026

    In this segment from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration,” our panelists discuss the challenges development teams face when upstream and downstream teams operate concurrently in a vacuum.

  8. Where Does Upstream End And Downstream Begin? 3/9/2026

    In this opening segment from the Bioprocess Online Live event, “Optimizing Process Development Through Upstream And Downstream Integration,” our panel of process development experts weighs in on where exactly to draw the line between upstream and downstream development.

  9. Increasing Precision And Cost Efficiency In The Lab With Gas Mixing 3/9/2026

    Understanding how cells function drives progress in disease research and drug discovery. Precise control of cellular environments is essential for reliable experiments and therapeutic development.

  10. Innovating Upstream Manufacturing For The Next Wave Of Gene Therapies 3/4/2026

    Explore a streamlined approach to transient AAV production, including yield improvements across serotypes, key transfection parameters, and practical guidance for scaling processes.