Bioprocessing Application Notes & Case Studies

1. A Comprehensive Blueprint For In Vitro Glycoengineering Adoption 2/13/2026

   In vitro glycoengineering enables precise control of therapeutic protein glycosylation, streamlining product consistency and development through a phased, risk-managed integration after initial purification.

2. mRNA Manufacturing With Fed-Batch In Vitro Transcription 2/13/2026

   A milliliter-scale approach to IVT optimization reveals how controlled feeding, precise pH management, and real-time monitoring can boost mRNA yield and streamline scale-up to larger bioreactor volumes.

3. Seamless Workflow For Environmental Monitoring 2/13/2026

   Learn how connected sampling tools and compliant monitoring software improve data integrity and streamline compressed gas testing workflows, offering a path to reliable environmental monitoring.

4. Practical Considerations For Aseptic Gowning In Contamination Control Strategies (CCS) 2/13/2026
5. Levers To Optimize The IVT Reaction For Increased mRNA Yield 2/10/2026

   Mastering IVT yield requires balancing magnesium and nucleotide ratios. Learn how specific buffers and pyrophosphatase optimize mRNA synthesis for scalable, high-quality therapeutic production.

6. Accelerate LNP Manufacturing With Automated Process Development 2/5/2026

   Manual LNP formulation introduces process variability that threatens particle quality and yield. As programs scale toward clinical production, maintaining strict control over CQAs becomes essential.

7. Integrated Upstream And Downstream Strategies For Robust mAb Manufacturing 2/5/2026

   Process robust mAb production requires understanding scale dependent cell environments, leveraging predictive models, and pursuing data driven control to minimize variability, optimize quality, and ensure reliable technology transfer across biomanufacturing scales.

8. Flexible Cell Culture Media For High Titer Production Of AAV In HEK 293 2/4/2026

   To maximize the results of viral titer and full capsids, it's necessary to undertake systematic process development and optimization of AAV production. The choice of cell culture medium is foundational.

9. Development Of A Non-Standard Protein Therapeutic 2/4/2026

   Discover how a tailored development approach transformed a complex therapeutic protein into a candidate ready for early-stage clinical trials.

10. Application Of A Dual Spiking Strategy In Viral Clearance Studies 2/3/2026

    Explore how an alternative spiking strategy can streamline viral clearance studies, reduce material demands, and maintain compliance while addressing the challenges posed by MLV and MMV.