Bioprocessing Application Notes & Case Studies

  1. Biocompatibility Studies On CHO Cell Culture In X-ray Irradiated BioBLU® Single-Use Bioreactors 9/5/2024

    In cell culture, the leakage of toxic or inhibitory chemicals from single-use bioreactors has become a growing concern. Explore recommendations for leachable studies.

  2. Human Induced Pluripotent Stem Cell Aggregate Expansion In Stirred-Tank Bioreactors Using SciVario® Twin Bioprocess Controller 9/5/2024

    Learn about a bioreactor-based Human Induced Pluripotent Stem Cell expansion workflow with the potential to improve cell therapy applications.

  3. Rapid Thermal Stability Screening Of High Concentration Biologic Drugs 9/3/2024

    Explore data demonstrating the effectiveness of a rapid screening-differential scanning calorimeter as well as its detection limits and the range of concentrations suitable for DSC analysis.

  4. Achieving Titer Increase Up To 4-Fold While Maintaining Product Quality 8/29/2024

    Discover customizable solutions for antibody manufacturing, as well as services for media optimization, feeding strategy optimization, and format conversion.

  5. Contrasting Dynamic Binding Capacity Across Affinity Resins 8/23/2024

    This study compares the Dynamic Binding Capacity (DBC) of two Purolite protein A resins and two competitor products in the purification of three types of antibody-related molecules.

  6. Re-Engineering A Complex Process For FDA Compliance 8/21/2024

    Discover the strategies that helped a company navigate a complex and shifting regulatory landscape to rapidly re-engineer a COVID-19 vaccine manufacturing process for FDA compliance.

  7. Accelerating Cold Chain Expansion: Responding To COVID-19 Challenges 8/21/2024

    Review how leveraging cross-functional teamwork helped complete a cold chain infrastructure expansion in a fraction of the expected timeline, ensuring the production of essential COVID-19 therapeutics.

  8. Expansion Of Cord Blood-derived CD34+ Cells In A Hollow-Fiber Bioreactor With 10% Standard Cytokine Concentration 8/20/2024

    CD34+ cells isolated from cord blood were expanded in a hollow-fiber bioreactor using a novel cytokine cocktail at one-tenth the standard concentration using a MSC-free coating strategy.

  9. CMO Validation As A Service 8/20/2024

    Learn about the highly successful commissioning and qualification of Wheeler's Oklahoma City CDMO facility with the overarching goal of ensuring all equipment was qualified for a Phase 3 clinical production campaign.

  10. Aseptic Expertise And Delivery Of Services 8/20/2024

    A pharmaceutical services company sought expert intervention after a routine requalification of their aseptic simulation process revealed a contaminated unit, leading to a two-month halt in commercial production.