Bioprocessing Application Notes & Case Studies

  1. Achieving Environmental Sustainability In Bioprocessing 10/26/2023

    Designing bioprocessing consumables has become increasingly important in the single-use space as a way to address sustainability concerns.

  2. Testing Cell-Based Immunotherapeutics For Microbial Contaminants 10/23/2023

    In this study, two different immune cell preparations were evaluated for their compatibility with the Milliflex® Rapid System to establish a USP and EP compliant method for rapid sterility testing.

  3. Monitoring Industry Contamination Down To Single Particle Level 10/23/2023

    Examine the benefit of using fluoropolymer film bags for the handling and storage of high value oligonucleotides- based payloads.

  4. Optimizing And Scaling Lentiviral Vector Production 10/23/2023

    Here, we outline how the upstream and downstream workflows of the VirusExpress® platform for lentiviral vectors were optimized through the use of design of experiments and supplementary studies.

  5. Reducing The Level Of Host Cell Proteins In The Bioreactor Harvest 10/20/2023

    Learn how MilliporeSigma helped a customer drastically reduce the level of HCPs in the bioreactor harvest prior to a production run to supply drug substance for a scheduled Phase 1 clinical trial.

  6. Accelerating Bulk Harvest Testing Using A CHO Animal Origin Free Virus Panel 10/19/2023

    Here, we describe the Blazar® CHO Animal Origin Free (AOF) panel for rapid adventitious virus detection, a degenerate PCR-based approach to broad virus screening.

  7. Outsourcing Manufacturing Of Acetic Acid And Benzyl Alcohol Solutions 10/19/2023

    Custom buffer solutions produced for a multinational biopharmaceutical company, enabled a fast facility expansion while still meeting the customers strict quality and regulatory requirements.

  8. Culturing Of Sf 9 Insect Cells With The BEVS, And SEAP Production 10/18/2023

    This study analyzes the cultured Sf9 insect cell line infected with a baculovirus expressing SEAP, and compares the growth behavior and productivity in different orbitally shaken culture vessels.

  9. Process Transfer Of CHO Cultivations 10/17/2023

    Explore the results of process-engineering characterization that demonstrate why the Minifors 2 is recommended for CHO cell culture processes but also other shear-sensitive cell types.

  10. The Systematic Characterization Of A Stirring Reactor 10/16/2023

    This application note describes a systematic characterization of a stirring reactor and it's suitability for microbial applications.