Bioprocessing Application Notes & Case Studies

  1. Digital Twins: A Game-Changer Throughout The Pharmaceutical Lifecycle 6/13/2025

    Discover how end-to-end digital twins and Integrated Process Models are transforming pharmaceutical manufacturing to enhance flexibility, accelerate time-to-market, and enable real-time decision-making through MES integration.

  2. Real-Time Monitoring Of Solvent Clearance By TFF In The ADC Process 6/13/2025

    Raman spectroscopy revolutionizes ADC manufacturing by enabling real-time monitoring of solvent clearance. Discover how it enhances process control, ensures regulatory compliance, and supports the production of high-quality therapeutics.

  3. Minimizing Fluid Loss By Monitoring Back Pressure During Clarification 6/12/2025

    Learn how a biopharma manufacturer mitigated the significant financial risk of fluid loss with a pressure-sensing pump that now protects their high-value product during clarification operations.

  4. Refurbishing Single-Use Systems To Drive Sustainability 6/11/2025

    How can biopharma reduce its environmental footprint? Discover a refurbishment model that transforms single-use components into a multi-use system, significantly cutting down on disposable plastic waste.

  5. Improved T Cell Expansion Using Closed, Automated Stirred-Tank Bioreactors 6/10/2025

    A shift from traditional rocking motion systems to stirred-tank bioreactors can enhance T cell expansion, offering greater scalability and more intimate process control.

  6. Comparing Serum-free To Serum-Supplemented Media 6/9/2025

    Reducing serum in vaccine manufacturing is a key consideration for lowering costs and improving supply security. We compare performance in serum-free versus serum-supplemented media.

  7. A Temperature-Stable Replacement For Animal Trypsin In Cell Dissociation Applications 6/9/2025

    Improve cell dissociation with a gentle, recombinant enzyme. This temperature-stable protease shows dissociation kinetics similar to porcine trypsin but with lower cell toxicity and greater overall purity.

  8. Evaluating The Impact Of Flexible Environmental Controls On HEK293 Cell Growth And Viability 6/2/2025

    Achieving high viable cell densities in HEK293 cultures is crucial. This study examines how precise environmental adjustments support robust growth for gene therapy applications.

  9. Evaluating Contamination Control For Open-Vessel Cultivation 5/30/2025

    Open-vessel cultivation can be challenging due to airborne contaminants. Learn how continuous air filtration within an incubator shaker ensures a particle-free environment.

  10. Benchmarking Filtration Performance Of TFF Cassettes 5/30/2025

    Optimize your protein purification workflow with tangential flow filtration by comparing membrane performance and exploring how protein concentration impacts flux and MWCO selection in lab-scale systems.