Bioprocessing Application Notes & Case Studies

31. Cultivate CHO Cell Cultures In A Specially Designed Incubation Shaker 10/13/2023

    Explore an incubation shaker that's particularly well suited for Chinese Hamster Ovary (CHO) cells alongside results when it was used with three shaker flask cultures set up with the CHO XM-111 cell line.

32. Regulatory And Quality Consulting, Operational Readiness Services 10/5/2023

    Learn how CAI aided a manufacturing company in merging food regulations with biopharmaceutical technology, allowing for the quick conversion of a small R&D facility into a GMP-compliant facility.

33. Achieve Fast And Efficient Isolation Of Exosomes From Stem Cells 10/5/2023

    Review the demonstration of how a bioreactor and bioreactor systems combination used to isolate exosomes after culturing human adiposederived stem cells in suspension on microcarriers.

34. Increasing iPSC Numbers Through Systematic Culture Process Optimization 10/5/2023

    Explore the use of a mini bioreactor system for stem cell culturing that optimized process parameters of a human induced pluripotent stem cell (hiPSC) culture in a step-by-step process.

35. On-line Measurement Of Glucose And Lactate With Automated Feedback Control 10/3/2023

    Achieve continuous, on-line monitoring with measurements as often as every two minutes, with no loss of bioreactor volume and no risk of contamination.

36. Enabling Real-Time Process Control 10/3/2023

    Defined control strategies enable more intensified and stable cell culture processes such as perfusion which may see dramatically improved productivity.

37. Simplifying Large-Scale Single-Use Filtration With A Novel Modular Approach 10/2/2023

    To meet large-scale production challenges, a modular platform-based approach was developed to offer a simplified, standardized design for protein- and virus-based therapy production processes.

38. Take Advantage Of Single-Use Technologies For Microbial Processes 9/29/2023

    Review the capabilities and robustness of a new single-use fermenter in a fast, exponentially growing, high cell density Escherichia coli (E. coli) process.

39. Developing A HIC Polishing Step For The Removal Of mAb Aggregates 9/28/2023

    Learn in-depth about the development of a flow-through polishing step that employs hydrophobic interaction chromatography for the elimination of monoclonal antibody aggregates.

40. Preparative Anion Exchange Chromatography For DNA ON Purification 9/28/2023

    Production of pure therapeutic DNA ONs requires efficient, scalable, and cost-effective chromatographic purification methods. This study explores a chromatography, resin pairing to determine it's effectiveness.