ABOUT W.L. GORE & ASSOCIATES, INC.
Traditional affinity chromatography technology has not kept pace with increased titers and other upstream process improvements, leading to bottlenecks and lower productivity in downstream purification. To gain flow and shorten processing times, traditional resin-based Protein A is often over-sized or underutilized – simply to keep up.
GORE Protein Capture Devices with Protein A utilize a unique membrane solution that provides a binding capacity advantage at high flow rates and improves the speed of purification versus traditional technologies. The GORE Protein Capture Device scales across sizes without compromising binding capacity or speed and is available is sizes for early drug discovery screening, late stage optimization, process development, and GMP clinical applications.
VIDEOS
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![Antibodies in the blood GettyImages-491763432]( "Protein Capture Devices For Antibody Purification")
Hear how you can utilize these protein capture devices to achieve 8 to 10 times the productivity of traditional resins in the first step in antibody purification from the product specialist from Gore.
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![Protein purification]( "Gore's Approach To Protein Purification And Chromatography")
Dr. Bill Barrett, Product Specialist for GORE® Protein Capture Devices with Protein A, discusses how Gore used its innovative membrane technology to improve productivity in mAb purification.
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![Affinity Chromatography Columns Impact On Drug Development Processes]( "Affinity Chromatography Columns Impact On Drug Development Processes")
In this Q&A with Dr. Bill Barrett, Product Specialist for GORE® Protein Capture Devices with Protein A considers the impact Gore’s affinity chromatography columns could have in drug discovery applications.
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![Benefits capture devices]( "The Benefits Of GORE® Protein Capture Devices")
In this Q&A with Dr. Bill Barrett, Product Specialist for GORE Protein Capture Devices with Protein A discusses the speed and capacity advantages of using the device, as well as potential uses in continuous chromatography.
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![Climate in pharma]( "The Climate In The Pharmaceutical Market Today")
In this Q&A with Dr. Bill Barrett, Product Specialist for GORE® Protein Capture Devices with Protein A discusses the climate in the pharmaceutical market and describes some of the productivity challenges scientists are facing in antibody purification today.
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![Developing Innovative Purification Solutions]( "Developing Innovative Purification Solutions")
In this Q&A with Dr. Bill Barrett, Product Specialist for GORE® Protein Capture Devices with Protein A talks about why he finds working to improve drug research processes with new technology so exciting.
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![Why Gore]( "An Innovative Membrane Technology Offerings And What It Holds For The Future")
In this Q&A with Dr. Bill Barrett, Product Specialist for GORE® Protein Capture Devices with Protein A discusses the innovative technology used in the membrane-based chromatography columns and where the technology is headed in the future.
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![GORE STA-PURE Pump Tubing]( "GORE® STA-PURE® Pump Tubing")
Can your tubing take the pressure? Durable. Resilient. Reliable. The unique ePTFE and platinum-cured silicone composite structure of GORE® STA-PURE® Pump Tubing, Series PCS for peristaltic pumps is ideal for critical drug processing applications. See for yourself how GORE STA-PURE Pump Tubing performs compared to conventional silicone tubing. This is just one product in a portfolio of products designed to meet the evolving needs of pharmaceutical and biopharmaceutical manufacturers.
CONTACT INFORMATION
W.L. Gore & Associates
402 Vieve's Way
Elkton, MD 21921
UNITED STATES
Phone: 410-506-8272
Contact: Bill Barrett
PRODUCTS
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![AfinityChromatography_slowdown_family_450x300_JUN23]( "High Binding Capacity And Rapid Antibody Purification")
Analyze performance results for Protein Capture Devices that assist in process development, pre-clinical and clinical GMP applications to see how you can increase your antibody purification productivity.
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Utilizing our expertise with fluoropolymers and knowledge designing healthcare solutions, Gore is now developing materials-based solutions for the pharmaceutical and OEM medical device manufacturers.
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![Diane Miller - 375x250_Chroma_dd_DataSheet_LSC]( "GORE® Protein Capture Device With Protein A For Drug Discovery Applications")
GORE Protein Capture Devices with immobilized Protein A are intended for affinity purification of monoclonal antibodies in drug discovery applications. The devices are offered in 1.0 mL and 3.5 mL and use a unique expanded polytetrafluoroethylene (ePTFE) membrane composite that provides a binding capacity advantage at high flow rates and improves the speed of purification.
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![Diane Miller - 375x250_Chroma_9mL_DataSheet_LSC]( "GORE® Protein Capture Device With Protein A, 9.0 mL For Process Development, Pre-Clinical, And Early Clinical Applications")
GORE Protein Capture Devices, 9.0 mL with Protein A are intended for the affinity purification of monoclonal antibodies from clarified harvest streams in process development, pre-clinical and early clinical applications. The devices use a unique expanded polytetrafluoroethylene (ePTFE) membrane composite that provides a binding capacity advantage at high flow rates and improves the speed of purification.
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![Diane Miller - 375x250_Tubing-PCS_DataSheet_LSC]( "GORE® STA-PURE® Pump Tubing Series PCS")
GORE® STA-PURE® Pump Tubing Series PCS enables reliable peristaltic pump operation in critical pharmaceutical and bio pharmaceutical processing applications. The unique composite structure of the tube adds strength and high flex durability for greater security against rupture under challenging conditions, up to 100 psig.
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![Diane Miller - 375x250_Tubing-PFL_DataSheet_LSC]( "GORE® STA-PURE® Pump Tubing Series PFL")
GORE® STA-PURE® Pump Tubing Series PFL enables reliable peristaltic pump operation in critical pharmaceutical and biopharmaceutical processing applications that include aggressive chemicals. The unique, chemically inert composite of Series PFL increases its durability for greater security against catastrophic failure due to rupture or chemical attack.
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![Protein Capture Devices]( "High Binding Capacity And Short Residence Time For Antibody Purification")
GORE Protein Capture Devices with Protein A are intended for the affinity purification of monoclonal antibodies and other proteins containing an Fc region derived from clarified cell culture harvests in process development to initial GMP clinical applications.
FEATURED ARTICLES
- Building A Fully Single-Use Process With Protein A Membrane Devices
- Optimize mAb Purification Using Protein A Membrane Chromatography
- Protein Capture Devices With Protein A - Improve Purification Times
- Eliminate Downstream Bottlenecks In Antibody-Based Therapies
- Scaling Analysis Of GORE® Protein Capture Devices
- Increased Productivity At Multiple Scales With Rapid CIP
- Carryover Analysis Through Two Consecutive Cell Culture Harvests
- Downstream Processing In The Age Of Precision Medicine
- A Faster And More Economical Path To Investigational New Drug Applications
- More Flexibility At Reduced Costs With Protein A Membrane Technology
- Protein A Membrane Tech To Eliminate Antibody Purification Bottlenecks
- Cleaning Protocols To Reduce The Effects Of Pressure Rise Over The Lifetime Of A Gore Protein Capture Device
- Rapid Cycling Using A Protein Capture Device With Protein A
- Evaluation Of Protein Capture Devices Used In-Series For mAb Purification
- Rapid mAb Purification Without A Liquid Chromatography Unit
- Evaluation: Dynamic Binding Capacity And Residence Time
- Highly Efficient Process For The Purification Of IgG
- NaOH Exposure Conditions For Protein Capture Device Operation