Insights On Upstream Manufacturing

  1. Perfusion Cell Line Development For Intensified Processes 5/5/2025

    The biopharmaceutical industry is transforming by shifting to continuous and intensified upstream bioprocesses, which are driven by evolving demands. Discover the key goals and innovations shaping this transition for modern healthcare.

  2. CLD To Upstream Optimization: Enhancing Biologics Quality, Productivity 4/30/2025

    Explore how advanced cell line development and upstream processing strategies optimize both productivity and therapeutic effectiveness, ensuring the development of high-quality biologics.

  3. Next-Generation Cell Therapy: Eliminating Thermal Shock In Electroporation 4/29/2025

    Conventional electroporation methods struggle with damaging heat buildup. Discover how innovative flow technology leverages physics to protect cells and enable large-scale therapeutic production.

  4. Why Cell Washing Is The Hidden Bottleneck In Gene-Edited Cell Therapy 4/29/2025

    Scaling up life-saving gene-edited cell therapies means tackling production inefficiencies. Overcoming the time-consuming and risky cell washing step is crucial for clinical and commercial success.

  5. Why Cell Line Screening Is Crucial For Successful CDC Assay Development 4/28/2025

    In developing a CDC assay for therapeutic mAb characterization or QC release testing, in addition to selecting a target cell line that expresses the mAb ligand, consideration should be made to the expression of CRPs on the cell surface.

  6. Greater Versatility: Multi-Well Inserts Allow For A Two-Chamber System 4/28/2025

    Multi-well inserts allowing for a two-chamber system that can expose cell cultures from above and below can provide greater versatility and expand research options compared to many standard cell culture plates.

  7. Helpful Biosafety Testing Innovations Where And When You Need Them 4/24/2025

    Monoclonal antibody manufacturing is advancing to boost efficiency, cut costs, and expand access, driven by innovation, demand, and the rise of biosimilars.

  8. Inside The Development Of An AAV8 Production Platform 4/24/2025

    Explore innovative solutions for AAV8 production challenges, which include scalability and purity, as well as learn how a collaboration with CDMO Matica Biotechnology ensures efficient, high-yield gene therapy vector production.

  9. High-Sensitivity Residual E. coli DNA Testing Supporting Biologics, CGT Development 4/23/2025

    Advancements in high-sensitivity residual DNA testing enhance the precision of plasmid DNA purity analysis, ensuring compliance with regulatory standards critical for manufacturing processes.

  10. Developing A Scalable Protocol For T Cell Activation, Expansion 4/23/2025

    Explore a scalable protocol for T cell activation and expansion, designed to enhance immunotherapy workflows. ​ This approach ensures robust T cell growth, viability, and memory phenotypes for clinical applications.