Insights On Upstream Manufacturing
-
An Animal-Free Fully Defined Workflow for Human iPSC Research
4/16/2024
This study explores the development of an iPSC workflow that is free from animal components, including an animal free expansion medium that supports the proliferation and growth of iPSC.
-
Bakuchiol Synthesis Optimization In S. Cerevisiae During Scale Up From 250mL To 5L
4/15/2024
Explore the significance of cost-effectiveness in synthetic biology and the successful scaling up of a process involving S. cerevisiae for the production of bakuchiol.
-
Simplifying CHO Cell Line Genetic Stability Testing
4/11/2024
Here, we describe the use of whole genome sequencing to perform a comprehensive assessment of genetic stability in clonally derived CHO cell banks using the Aptegra™ CHO genetic stability assay.
-
Enhancing Efficiency And Accuracy In Cell Line Development
4/11/2024
Gain insights into the latest advancements in high-resolution multi-plane whole well imaging and the impact of AI-powered image analysis on clonality decisions and optimal clone selection.
-
A Single, Comprehensive Method For Genetic Stability Testing
4/11/2024
Discover a genetic stability assay that is fully validated to GMP quality standards and outperforms traditional testing methods with its enhanced speed and accuracy.
-
Scaling Up mAb Process Development To A 5L Bioreactor
4/10/2024
This study, conducted with cloud-connected bioreactors designed to accommodate CHO cells, showcases this technology transfer by comparing results obtained from shake flask cultures at various scales.
-
Instant Implementation Of Raman-Based Monitoring
4/9/2024
This platform, based on Raman technology with a de novo approach, operates as effortlessly as a pH-meter, providing real-time measurements of key process parameters such as glucose, lactate, and biomass.
-
Advancing 3D Cell Culture Models For Clinical Relevance
4/9/2024
Concerns about in vitro relevance and animal study limits have advanced cell culture tech. Explore how Organ-Chips offer a refined approach to studying human physiology.
-
Accelerating DNA To MCB To Generate High-Titer And High-Quality Cell Lines
4/8/2024
The goal of this study was to implement a high-throughput technology for the single cell cloning step, supporting improved clone outgrowth, early prediction of high producers, and fast clone expansion.
-
High-Throughput Media Optimization For CHO Cell Lines
4/8/2024
This study introduces a methodology that integrates data-rich experiments with advanced data analytics and can elevate mAB titer, enhance productivity, and help achieve key quality attributes.