Insights On Upstream Manufacturing

  1. Lipid Nanoparticles Boost CRISPR HDR Gene Insertion in Human T Cells 12/12/2025

    Lipid nanoparticles enable precise, non-viral gene editing in T cells to achieve high HDR efficiency and viability in scalable workflows. Explore how this approach overcomes viral vector limitations.

  2. Hear From The Experts: LNPs Driving The Future Of Cell Therapy 12/12/2025

    Explore how lipid nanoparticles are driving breakthroughs in cell therapy, from mRNA-based immune cell engineering to genome editing for CAR T cells and HSPCs from leading experts.

  3. Building A Biomanufacturing Ecosystem For Supply Agility Starts Early 12/9/2025

    A unified, modular biomanufacturing ecosystem combining rapid CLD, flexible purification, and scalable global capacity can accelerate production and strengthen supply agility amid rising demand.

  4. Efficient Stem Cell Expansion In Bioreactors For Immunotherapy 12/9/2025

    A scalable bioreactor process enables efficient expansion of cord blood-derived HSCs and NK cell differentiation, delivering high purity and strong cytotoxicity, advancing immune cell therapies.

  5. Advances In mAb Purification With Optimized Membrane And A New Screen 12/9/2025

    Optimized membranes and channel geometry accelerate mAb purification, cutting process times while maintaining product integrity. Discover how these advancements improve scalability and sustainability.

  6. MES Apps Built For Speed And Seamless Integration 12/9/2025

    Digitize bioprocess workflows to achieve consistent, paper-free execution that deploys up to 66% quicker than traditional MES with a cloud-based, no-code platform built for single-use bioprocessing.

  7. Insights To Sustainable Signaling Devices With Bioluminescent Bacteria 12/5/2025

    A protocol for scaling a bioluminescent marine strain is validated, revealing atypical light kinetics that necessitate an immediate harvesting window for maximum performance.

  8. Metabolic Pathways And The Immune System 12/5/2025

    Metabolic pathways define immune cell roles, from glycolysis fueling inflammation to fatty acid oxidation sustaining memory and tolerance. Discover how energy metabolism shapes immune responses.

  9. AOC GMP Manufacture For A FIH Study 12/5/2025

    Successful development of AOCs for FIH studies requires robust GMP processes and efficient scale-up. A key step is careful management of a multi-day conjugation process with vital in-process checks.

  10. The Proven Supplement For CAR-T Solid Tumor Cytotoxicity 12/4/2025

    Optimize cell culture for solid tumor research. Replacing traditional serum can significantly enhance CAR-T cytotoxicity, improve consistency, and streamline the path to GMP-ready workflows.