Insights On Upstream Manufacturing

  1. Game-Changing CLD Platforms: Strategies, Technologies, Workflows 10/21/2025

    Selecting the right cell line platform is complex. Learn how flexible strategies, integrated technologies, and expert workflows enable high productivity, rapid timelines, and a de-risked path to clinical success.

  2. Developing Antibodies To Block Neuroinflammation With MindImmune's Stevin Zorn, Ph.D. 10/20/2025

    In this episode of "Better Biopharma," host Tyler Menichiello is joined by MindImmune's president and CEO, Stevin Zorn, Ph.D. They discuss the development of the company's lead candidate, MITI-101, a monoclonal antibody designed to prevent peripheral immune cells from entering the brain and driving neuroinflammation linked to Alzheimer's disease.

  3. Predicting The Performance Of Perfusion Media In A Continuous Bioreactor 10/17/2025

    Small-scale perfusion-mimic models can effectively predict media performance in continuous bioreactors to help optimize cell density, productivity, and scalability for CHO cell lines.

  4. Simplify Process Scale-Up With An Innovative Single-Use Bioreactor 10/15/2025

    Consistent cell growth and protein yields from 5 L to 5,000 L show how a unified bioreactor design can simplify scale-up, reduce risk, and accelerate upstream process development in bioproduction.

  5. Centrifuge Bioprocess Bags: Closed, Sterile Cell Harvest, And Separation 10/15/2025

    Explore single-use centrifuge bags designed for efficient cell harvest and separation that offer robust film technology, full traceability, and seamless integration with Sorvall BIOS 16 systems.

  6. Break The Cell Therapy Manufacturing Bottleneck With Day-0 Transduction, Day-3 Harvest 10/14/2025

    Discover the potential of T1 cell-derived nanoparticles (CDNPs) to accelerate T-cell activation. See how CDNPs’ unique mechanism of mimicking physiological immune stimulation positions them for broad use.

  7. High-Throughput Screening For High-Performance Cell Culture Media Development 10/14/2025

    Learn about a high-throughput screening method that successfully optimized cell culture media, leading to a greater than 3-fold improvement in viral genome titer for AAV2 production.

  8. Advanced Approaches For Developing And Optimizing Perfusion Platforms 10/14/2025

    Discover how to effectively use small-scale perfusion-mimic systems to identify optimal cell culture media and significantly increase volumetric productivity for large-scale biomanufacturing.

  9. Cell Bank And Scale Up Strategies For MSC And Exosome Manufacturing 10/9/2025

    Discover how effective cell banking and scale-up strategies can reduce risk and cost in advanced therapy manufacturing. Learn practical ways to meet increasing cell and exosome quantity needs.

  10. Redefining T Cell Culture Media 10/6/2025

    Media selection is key to CAR-T cell success. Learn how a serum-free, xeno-free medium boosts transduction efficiency, maintains quality, and streamlines the path to clinical scale-up.