Insights On Downstream Manufacturing

  1. Periodic Counter Current Chromatography: A Step Toward Continuous DSP 12/19/2025

    PCC boosts Protein A capture efficiency, cuts resin costs, increases productivity, and enables continuous downstream processing without sacrificing quality or compliance.

     

  2. Twist Of Two: 2D-LC For Oligos 12/16/2025

    Discover how coupling orthogonal mechanisms reveals hidden impurities and creates a more robust strategy for characterizing complex oligonucleotide samples.

  3. A New Specialist For Oligonucleotides With Advantages 12/16/2025

    Discover how hybrid silica technologies ensure stability and high resolution in IP-RP chromatography applications while protecting instrumentation from excessive wear and tear.

  4. The Secret To Pure Oligos: Why Anion Exchange Chromatography Rules At Scale 12/16/2025

    Discover how anion exchange chromatography delivers high loading capacity and clinical-grade purity while addressing common scale-up challenges like aggregation and equipment longevity.

  5. How To Navigate Through The Jungle Of Columns? 12/15/2025

    Whether prioritizing mass spectrometry compatibility or loading capacity, understanding the specific trade-offs between IP-RP, AEX, and SEC methodologies is essential for successful characterization.

  6. Size Matters: Mastering Size Exclusion For Oligos 12/15/2025

    Learn how to separate molecules strictly by size, effectively remove salts, and select the correct pore specifications for a gentle, non-destructive purification workflow.

  7. Charged For Action: The Hidden Secrets Of AEX Oligonucleotide Analysis 12/15/2025

    Understanding how to fine-tune pH and ionic strength allows for the detection of truncated sequences and single-nucleotide variants, turning complex purification challenges into reproducible data.

  8. The Hitchhiker´s Guide To Creating Oligonucleotides From Start To Finish 12/15/2025

    Producing high-quality oligonucleotides demands precise execution across multiple stages. Gain a clearer understanding of the complete mid-scale production workflow and necessary quality control measures.

  9. How To Reduce Batch Loss In Biopharma Production 12/12/2025

    Batch failures in biopharma remain costly despite improvements. Learn the leading causes in downstream purification and how supplier expertise can help reduce risk and protect production.

  10. Aggregate Analysis Of Insulin Analogues 12/11/2025

    Therapeutic peptide purity is critical. Learn about SEC analysis of high molecular weight impurities in Insulin Glargine and Insulin Lispro to ensure product quality and safety.