Insights On Downstream Manufacturing

  1. Assessing Quality AAV Attributes Including Aggregation And Capsid Load 12/11/2025

    Assessing AAV critical quality attributes (CQAs)—like aggregation and the full-to-empty capsid ratio—is vital for gene therapy safety and efficacy. See how SEC-MALS enables reliable analysis.

  2. Challenges And Solutions In Lyophilization Development For ADCs 12/10/2025

    Successful ADC lyophilization requires a robust, individualized process driven by thermal characterization using DSC and FDM to define the critical parameters for stability and efficient manufacturing.

  3. Benefits Of Isolator Technology In Fill-Finish 12/10/2025

    Isolator technology enhances sterility assurance, reduces contamination risk, improves operator safety, and supports regulatory compliance, making it essential for modern aseptic fill-finish operations.

  4. Advances In mAb Purification With Optimized Membrane And A New Screen 12/9/2025

    Optimized membranes and channel geometry accelerate mAb purification, cutting process times while maintaining product integrity. Discover how these advancements improve scalability and sustainability.

  5. Fill And Finish: Your Final Step Is Our First Priority 12/9/2025

    Fill and finish demands precision, compliance, and adaptability. Learn how flexible solutions and expert support can help you overcome complexity, reduce risk, and ensure quality in this final step.

  6. AOC Conjugation – mAb With SiRNA 12/5/2025

    See how to overcome risks in mAb-SiRNA conjugation, including disulfide scrambling and SiRNA deconjugation, by using advanced chemical and operational solutions to improve material yield and stability.

  7. Unlock Productivity In mAb Production: Upstream And Downstream Intensification 12/3/2025

    Boost your mAb manufacturing efficiency by mastering upstream and downstream intensification strategies. Learn how to minimize cost and time while increasing overall productivity.

  8. Building An Oral Vaccine Platform With Vaxart's Sean Tucker, Ph.D. 12/2/2025

    In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Sean Tucker, Ph.D., founder and chief scientific officer at Vaxart, a company developing oral recombinant pill vaccines.

  9. A Better Way For Closed-System Processing In Cell Therapy 12/1/2025

    Small changes in aseptic processing can yield major operational improvements. Streamlining closed-system connections helps reduce contamination risks, supports scalability, and lowers manufacturing costs.

  10. Controlled Nucleation Offers Homogeneity And Batch Consistency 11/24/2025

    Controlled nucleation standardizes freezing across all vials, leading to uniform ice crystals and improved lyo cake quality. This critical step reduces variability and supports robust product scale-up.