Insights On Downstream Manufacturing

  1. Membrane Adsorber Chromatography In Oligo-mAb Conjugation 8/25/2025

    Discover how the team was able to expedite the conjugation of an oligonucleotide-monoclonal antibody (oligo-mAb) program leveraging experience in chromatography.

  2. Why Manual Bottle Filling Puts Biomanufacturers At Risk 8/21/2025

    Manual bottle filling can introduce significant risks, impacting accuracy, sterility, and compliance. Learn how automation can improve product quality, enhance patient safety, and increase efficiency.

  3. Time To Intensify: Taking mAb Manufacturing To The Next Level 8/19/2025

    Explore how process intensification can revolutionize monoclonal antibody manufacturing to boost productivity, cut costs, and enhance sustainability with scalable strategies and real-world results.

  4. A Strategic Assessment Tool For Modernizing Buffer Preparation In Biologics Facilities 8/14/2025

    Modern biomanufacturing requires a strategic, multi-criteria approach to buffer management. Discover how a hybrid model can optimize your operations and address fluctuating demands.

  5. Scalability And Reproducibility Of The AAV9 Capture Step 8/13/2025

    Scaling gene therapies beyond rare diseases demands innovation. Discover a chromatography system that boosts efficiency, protects product integrity, and overcomes viral vector manufacturing challenges.

  6. The Science of Selection: Choosing The Right Hollow Fiber Filter 8/13/2025

    Discover how hollow fiber tangential flow filtration enhances downstream bioprocessing with efficient ultrafiltration and diafiltration, reduced fouling, and scalable performance.

  7. Why Membrane Matters In AAV Filtration 8/13/2025

    Gene therapy is revolutionizing medicine to offer one-time treatments. Find out how AAV vectors are leading the way to optimize production and make these life-changing therapies accessible.

  8. Developing An In Vivo CAR-T With Interius BioTherapeutics' Sianny Christanti and Babu Medi, Ph.D. 8/12/2025

    On this episode of Better Biopharma, Interius BioTherapeutics’ Sianny Christanti and Babu Medi, Ph.D., explain how the company is re-engineering a lentiviral vector to enable INT2104, its off-the-shelf, in vivo CAR T-cell therapy. They discuss the vector's design and its manufacturability, as well as the analytical and regulatory challenges of bringing this first-in-human therapy to the clinic.

  9. A Comprehensive Walkthrough Of An Innovative System 8/11/2025

    Explore the KrosFlo RS® 30 TFF System with Lucas Smith as he highlights its automation, real-time control, and cGMP-ready design that is ideal for efficient, scalable bioprocessing.

  10. An In-Depth Exploration Of Cutting-Edge Technology 8/11/2025

    Explore the innovative KrosFlo® RS 50 TFF System by Repligen that features intelligent mixing, full automation, and scalable filtration for advanced bioprocessing applications.