Insights On Downstream Manufacturing

  1. Perform Multiple Chromatography Steps On A Single System 2/26/2024

    The Resolute® BioSC platform is a highly modular multi-step chromatography system designed to purify biologics. The platform can be configured to design your own multi-step process.

  2. Characterization Of Host Cell Proteins By Liquid Chromatography - Mass Spectrometry 2/26/2024

    Explore an established liquid chromatography – tandem mass spectrometry (LC-MS/MS) method for characterization of residual HCPs in monoclonal antibody (mAb) products.

  3. POROS Benzyl Ultra Viral Clearance And Impurity Removal For A Novel Antibody Format 2/26/2024

    A firm that develops innovative ADCs for cancer treatments, has been exploring the effectiveness of POROS™ Benzyl Ultra, a hydrophobic interaction chromatography resin, in reducing HMW species.

  4. Getting The Most From Your Inline Buffer Formulation System 2/26/2024

    An automated, integrated, responsive inline buffer formulation system can help eliminate the need for intermediate storage, reduce facility footprint, and accelerate timelines.

  5. A New Way To Perform mAb Capture 2/21/2024

    Combining high-productivity chromatography methods and SU affinity membranes delivers a viable alternative to the current packed bed Protein A capture techniques for intensified purification of mAbs.

  6. Re-Imagining Chromatography: Building Efficient Downstream Processes 2/21/2024

    Explore a stepwise approach for integrating process intensification principles into an existing process to increase productivity, reduce costs, and improve process sustainability.

  7. Implementing Chromatographic Methods For Evaluating Large-Scale Monolithic Columns For AAV Capsid Separation 2/21/2024

    Review the evaluation of highly reproducible QA-modified CIM® monolithic columns. The aim was to elute AAV capsids in a very narrow conductivity range, regardless of the batch and size of the column used.

  8. Integrated And Connected Downstream Processing Of mAbs 2/21/2024

    We describe how intensifying two chromatography polishing steps by developing unit operations using Sartobind® Q and CMM HyperCel saves buffer volumes and accelerates the downstream process.

  9. Comparability Study Of An Ion Exchange Monolith And Affinity Resin 2/21/2024

    A side-by-side comparison was performed using a CIMmultus® SO3—1 mL (2 µm) column and a commercially available affinity resin that binds several AAV serotypes.

  10. The Cure For The Cure 2/14/2024

    Traditional aseptic filling solutions can introduce contamination and variability. Learn about Cytiva's commitment to finding innovative solutions and improving patient outcomes in the field of medicine.