Insights On Downstream Manufacturing
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Viral Clearance Capability Of POROS Hydrophobic Interaction Chromatography Resins
3/11/2024
The present study highlights the viral clearance performance of POROS HIC resins, either in FT or B/E mode, in the purification process of two monoclonal antibodies.
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Using Affinity Chromatography For The Purification Of Lentiviral Particles
3/11/2024
This new affinity chromatography resin offers an efficient and scalable purification method for lentiviral particles in combination with gentle elution conditions to retain viral infectivity.
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Sterilizing Grade Filter Performance With Biologic Drugs
3/11/2024
Here, we analyze the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins and demonstrate how filter selection can impact your process.
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Enable Custom Chromatography Solutions For Downstream Processing
3/8/2024
This study explores the development of a POROS prototype resin, investigating ligand immobilization, optimizing coupling conditions, and evaluating bead morphology impact on resin performance.
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Aggregate Removal From mAbs By Hydrophobic Interaction Chromatography
3/7/2024
Review the results of a study where Hydrophobic Interaction Chromatography (HIC) techniques were used with a resin for the removal of aggregates in the manufacturing of monoclonal antibodies.
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Selecting Container Closure Systems With Confidence: Lyophilization
3/7/2024
Experts take you through the entire selection process for primary packaging components for lyophilization and provide aspects to consider for all relevant attributes.
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Single-Use Microbial Impactor On A Filling Line
3/6/2024
Discover the advantages of a single-use microbial impactor through a demonstration of its ease of use in an isolator and an explanation of its ability to eliminate false positives.
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Exosome Isolation By TFF And Size Exclusion Chromatography
3/6/2024
Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.
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A Scalable Single-Use Two-Step pDNA Purification Process
3/6/2024
Evaluate the performance of a single-use two-step plasmid purification process, and see how it compares to the existing three-step purification method.
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Safer AAV Through Reduced Host-Cell DNA Encapsidation
3/6/2024
While most hcDNA molecules outside AAV particles can be eliminated during downstream processing, encapsidated hcDNA molecules remain largely undetectable. Learn how to overcome this critical issue.