Culture Development White Papers and Case Studies
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Air-Wheel™ Bioreactor Offers Seamless Transition From Stirred-Tanks In Fed-Batch CHO Process
1/29/2013
The novel, low shear single-use bioreactor system from PBS Biotech® has the potential to offer unmatched performance in shear-sensitive applications involving microcarriers and viral production, but we show here that processes developed and optimized in a traditional stainless steel stirred-tank system can be easily transferred over to the PBS platform with at least equivalent results and the potential for better performance.
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Meeting BioPharma Needs For Lower Operating Cost And Faster Time To Market
11/28/2012
Broad adoption awaits fully scalable GMP systems, improved and less costly disposables, better analytics, greater process automation and low-shear mixing.
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The Next Bioprocessing Revolution: Functional Additives
11/1/2012
Now that many bioproduction technologies and processes are reaching maturity, manufacturers are seeking out the next level of refinements. As an extension of successful fed-batch strategies (such as the use of matched media and feeds), the next stage in bioprocess refinement involves the development of highly concentrated functional additives that can be added to each bioreactor run in the smallest amount necessary to give good titer increases.
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Multi-Parallel Microscale Bioreactor System Unlocks Bottlenecks In Bioprocess Development
9/13/2012
Implementation of high throughput automated systems is recognized as a valuable approach in the field of bioprocess development. An efficient multi-parallel microscale bioreactor system can unlock development bottlenecks in a variety of bioprocess applications, such as cell line screening, media development, feed and process optimisation, QbD and DoE studies.
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5 Challenges That Continue To Plague The $2B Pharmacovigilance Sector
6/15/2012
The Asia Pacific region is fast becoming the growth center of the worldwide pharmaceuticals market. By 2015, these markets are projected to account for almost a third of the total pharmaceutical sales worldwide. By Pharma IQ
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Automation Of A Novel Cell-Based ELISA For Cell Signaling Pathway Analysis
5/21/2012
Monitoring and quantifying cell signaling pathways is critical for understanding the behavior of cell processes and many disease states. By Wendy Goodrich and Peter Banks, BioTek Instruments, Inc., Winooski, VT and Ron Osmond and Antony Sheehan, TGR Biosciences, Adelaide, Australia
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Evaluating Real Time Viability Detectors
5/9/2012
Rapid microbiological methods have been around for years but have yet to make a significant impact on pharma manufacturing despite the advantages they offer in cost savings and process improvement.
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Managing Cell-Based Potency Assays: From Development To Lifecycle Maintenance
4/24/2012
Characterization of a biological product — which includes the determination of physicochemical properties, biological activity, immunochemical properties, purity and impurities — is necessary to establish the safety and efficacy profile of a given product (ICH Q6B). By Dr. Weihong Wang, manager, Molecular and Cell Biology, Eurofins Lancaster Laboratories
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Decontamination Of Laboratory Animal Research Rooms Using Vaporized Hydrogen Peroxide (VHP®)
4/12/2012
Walter Reed Army Institute for Research is a U. S. government laboratory facility located in the Washington D.C. area.
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What to Expect When They’re Inspecting: Part I
4/9/2012
The next time you attend an industry function like BIO, BioEast, or an AABB conference, start up a conversation about FDA inspections with those seated at your luncheon table. More than likely, everybody will describe a different inspection experience and no two perceptions will be the same.