Culture Development White Papers and Case Studies
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Global Biochemical Profiling For Bioprocess Optimization
6/12/2013
It is widely understood that the production phase of bioprocessing can have a significant impact on the overall profitability of the biopharmaceutical.
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Downstream Scale-Up Purification Of Influenza Virus
5/29/2013
This application note describes a case study where live influenza virus was purified using single-use ReadyToProcess technology.
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How To Analyze Nuclear Stained Cells Using A Multi-Mode Microplate Reader With DAPI-Stained Cells
4/18/2013
The imaging and analysis of fluorescently stained cells has traditionally been accomplished using manual microscopic methods with low numbers of samples, while the analysis of higher sample numbers requires the use of very expensive dedicated microscopes.
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Zeta Plus™ VR Series Filters For Viral Reduction In Biopharmaceutical Processes
4/6/2013
The removal and/or inactivation to a high level of assurance of contaminating viruses from biotherapeutics is a requisite for ensuring product safety. Many biotherapeutic products are produced using mammalian cell culture techniques. Contaminating viruses can enter cell culture systems from a number of sources including animal derived nutrient additives, the cell line itself, or through adventitious contamination via human or animal process contact. Screening methods to detect viral contamination are not adequate to ensure product safety due to limitations in assay sensitivity. By 3M Purification Inc
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How To Classify Biological Specimens For Transport
4/2/2013
Transportation of biological substances and infectious materials has become increasingly challenging. Understanding the dangerous goods classification requirements is critical to ensure that your shipments are in compliance with the law.
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Avoiding Drug Shortages With Microbial Detection
3/6/2013
Over the past year, critical drug shortages used to treat a host of life-threatening illnesses have been making headlines. Microbial contamination has been cited as a major contributor to the shortage, yet the prevailing practices to ensure the safety of drugs have been slow to change. In most cases, quality assurance practices safeguarding the drug making environment continue to rely on periodic air and a culturing method from a prior century. By Aric Meares, President and CEO, BioVigilant
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How DSC Helped DowBrands Achieve Cost Efficiency And Exceed All Other Goals
3/5/2013
It’s amazing what can happen when you forge a true partnership with a company you can trust.
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Health Care Supply Chain Requires Regulatory Expertise And Execution
2/26/2013
In the U.S. health care supply chain, before a medical device or drug can be shipped -- state and county licenses must be secured, FDA Quality Systems regulations must be complied with, and accreditations must be earned. The health care supply chain plays a key role in patient safety by ensuring the integrity of products from the time they are manufactured to the time they are delivered to a health care provider or patient.
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Automated Bioluminescent ADCC Reporter Bioassay Using Bioengineered Jurkat Cells
2/10/2013
Pharmaceutical companies are increasingly exploring new biologic and biosimilar products, and thus increasing monoclonal antibody (mAb) immunotherapeutic research. By Tracy Worzella, Promega Corporation and Brad Larson, Applications Department, BioTek Instruments, Inc.
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Air-Wheel™ Bioreactor Offers Seamless Transition From Stirred-Tanks In Fed-Batch CHO Process
1/29/2013
The novel, low shear single-use bioreactor system from PBS Biotech® has the potential to offer unmatched performance in shear-sensitive applications involving microcarriers and viral production, but we show here that processes developed and optimized in a traditional stainless steel stirred-tank system can be easily transferred over to the PBS platform with at least equivalent results and the potential for better performance.