Culture Development White Papers and Case Studies

1. The Client Experience—Key to a CDMO's Success 5/23/2014

   In the dynamic contract development and manufacturing organization (CDMO) industry, client-focused businesses succeed in retaining and growing our client base by delivering on project objectives and satisfying a client’s expectations.

2. Live Cell Imaging Of GPCR Dependent Second-Messenger Systems 4/15/2014

   A significant proportion of academic and drug discovery research is devoted towards the elucidation of second messenger signaling cascades resulting from interactions between G-protein coupled receptors (GPCR) and their ligands. By Paul Held Ph. D. and Peter Banks, Ph. D., BioTek Instruments, Inc. and Paul Tewson, Anne Marie Quinn and Thom Hughes, Montana Molecular

3. Important Considerations For Implementing A Single-Use Biomanufacturing Strategy 10/18/2013

   Recent trends in biomanufacturing technology and the biopharmaceutical market are supporting the increased adoption of single-use (SU) manufacturing systems. On the demand-side, the biopharma industry is focusing on niche and rare diseases with smaller patient populations, resulting in the need for smaller, more agile biomanufacturing capacity. By Jodi M. Zobrist and Nicole W. O'Brien, Ph. D., Gallus Biopharmaceuticals, LLC

4. Are You Planning To Fail? 9/26/2013

   The problem with managing demand and supply variability in the supply chain stems from the inability of traditional planning systems to solve the bullwhip effect, a problem demonstrated by Prof. By Narayan Laksham and Richard Sherman

5. Automation Of HTRF® elF4E Kinase Assay Using A 3D Tumoroid- Based Cell Model 9/17/2013

   Three-dimensional (3D) cell culture is poised to meet the need for a more in vivo-like cellular model with which to test large and small molecules. This is accomplished by providing a method that allows for the reorganization of cells into a format which re-establishes the necessary cellular architecture and communication networks seen in normal tissue. Recently a methodology has been put forth that incorporates a simplified procedure for the creation of a cell and collagen hydrogel mix. The inclusion of appropriate liquid handling instrumentation can further simplify the process and ensure the generation of accurate, robust results. By Brad Larson, Peter Banks, Nicolas Pierre and Grant Cameron

6. Global Biochemical Profiling For Bioprocess Optimization 6/12/2013

   It is widely understood that the production phase of bioprocessing can have a significant impact on the overall profitability of the biopharmaceutical.

7. Zeta Plus™ VR Series Filters For Viral Reduction In Biopharmaceutical Processes 4/6/2013

   The removal and/or inactivation to a high level of assurance of contaminating viruses from biotherapeutics is a requisite for ensuring product safety. Many biotherapeutic products are produced using mammalian cell culture techniques. Contaminating viruses can enter cell culture systems from a number of sources including animal derived nutrient additives, the cell line itself, or through adventitious contamination via human or animal process contact. Screening methods to detect viral contamination are not adequate to ensure product safety due to limitations in assay sensitivity. By 3M Purification Inc

8. Avoiding Drug Shortages With Microbial Detection 3/6/2013

   Over the past year, critical drug shortages used to treat a host of life-threatening illnesses have been making headlines. Microbial contamination has been cited as a major contributor to the shortage, yet the prevailing practices to ensure the safety of drugs have been slow to change. In most cases, quality assurance practices safeguarding the drug making environment continue to rely on periodic air and a culturing method from a prior century. By Aric Meares, President and CEO, BioVigilant

9. How DSC Helped DowBrands Achieve Cost Efficiency And Exceed All Other Goals 3/5/2013

   It’s amazing what can happen when you forge a true partnership with a company you can trust.

10. Automated Bioluminescent ADCC Reporter Bioassay Using Bioengineered Jurkat Cells 2/10/2013

    Pharmaceutical companies are increasingly exploring new biologic and biosimilar products, and thus increasing monoclonal antibody (mAb) immunotherapeutic research. By Tracy Worzella, Promega Corporation and Brad Larson, Applications Department, BioTek Instruments, Inc.