Rapid Thermal Stability Screening Of High Concentration Biologic Drugs

Testing the thermal stability of biotherapeutics is critical for ensuring product quality and supporting the regulatory approval of biologic drugs. The TA Instruments™ RS-DSC (Rapid Screening-Differential Scanning Calorimeter) offers a solution for analyzing up to 24 samples at once. Additionally, it allows for the evaluation of protein drug candidates at high concentrations using low-volume disposable microfluidic chips. This application note presents data showcasing the effectiveness of the TA Instruments RS-DSC and evaluates its detection limits and the range of concentrations suitable for DSC analysis.