Practical strategies for reducing handling steps, minimizing product loss risk, and improving operator efficiency in frozen drug substance cold chain operations.

Legacy facilities weren't built for today's cold chain complexity. How are CDMOs squeezing more capacity from fixed footprints without breaking what already works?

Explore the risk factors in small-volume fluid management, learn where manual processes introduce variability, and find out how closed, pump-driven single-use systems can improve accuracy and consistency.

Discover how closed-system approaches in HPAPI and ADC manufacturing reduce operator exposure, support Annex 1 alignment, and deliver labor savings of up to 90%.

Your ADC handling protocol may have gaps you have not accounted for yet. Examine seven considerations that are reshaping how manufacturers protect product integrity and operator safety.

ADC payloads active at nanogram concentrations create serious operator safety risks. Here is what manufacturers must get right to protect operators across every stage of production.

Discover how plasmid design, transfection protocols, and controlled freezing methods combine to address critical manufacturing challenges in lentiviral vector production for gene therapy applications.

Regulatory frameworks for biopharmaceutical cold chain management are more interconnected than most manufacturers expect — and the gaps between them are where compliance risk lives.

Learn how the transition to plate-based freezing with single-use technologies improves scalability and contamination control while ensuring uniform thermal transfer for high-value bulk drug substances.

Until recently, only isolated solutions for working filling, freezing/thawing and transporting sensitive drug materials were available. Learn how we've addressed this problem with end-to-end bottle solutions.

Uneven ice formation during bottle freezing creates a "Volcano Effect," pushing solutes into highly concentrated zones. This test-based study explains this risk to drug substance quality.

Learn five critical considerations for freezing bottles, including uniform rate control, container integrity, and selecting the right freezing technology to maintain product stability and process efficiency.

Manual bottle filling can introduce significant risks, impacting accuracy, sterility, and compliance. Learn how automation can improve product quality, enhance patient safety, and increase efficiency.

Explore the dynamic field of therapeutic biotechnology, examining the intricacies of mAb manufacturing and uncovering the often-overlooked factors driving high production costs.

Explore best practices for cryopreserving small-volume advanced therapy medicinal products (ATMPs), emphasizing sterility, cell viability, and efficiency using innovative single-use systems and aseptic connectors.

Tired of manual manipulation risks in biopharmaceuticals? Discover how automated homogenization ensures consistent cell counts and concentration levels, improving patient safety and process reproducibility.

Five years post-COVID, global vaccine development is experiencing a surge of innovation. Let's examine seven key trends shaping the future of vaccine manufacturing and accessibility in 2025.

Biopharmaceutical fermentation faces unique challenges. Overcoming issues in cold chain logistics, scalability, and product quality preservation is crucial for successful production.

Dual sourcing strengthens the pharmaceutical supply chain for single-use assemblies. Learn how this strategy and multi-sourcing can enhance resilience and adaptability in the face of disruptions.

Uncover the risks associated with Ribonuclease (RNase) contamination and the strategies manufacturers can employ to mitigate these threats and ensure the integrity of their products.

Choosing the right cold storage freezer can be challenging. High storage density, modular shelving, and controlled temperature are a few key considerations for superior long-term cold storage.

Pharmaceutical cold chain management ensures temperature-controlled storage and transport of sensitive drugs. Learn about the key freezing ranges and their importance for various biopharmaceuticals.

Explore the benefits of single-use technologies to enhance safety, streamline your operations, and elevate your biopharmaceutical processes as they relate to ADCs.

Delve into the intricacies of ADC production and learn how cutting-edge technologies are being deployed to overcome these hurdles to bring life-saving treatments to patients.

Take a closer look into research aimed at enhancing the cryogenic freezing process of the mammalian CHO-K1 cell line using a controlled-rate liquid nitrogen freezer.

Explore the challenges of adding cryoprotectants, how they can help reduce the effects of harmful conditions like ice crystals, and the need for future stability studies and substitutes for toxic CPAs.

Explore safety measures for handling mAbs in production in order to meet strict requirements that prevent contamination, product loss and exposure to cytotoxic agents or radioisotopes.

The integration of single-use technologies in upstream and downstream bioprocessing stages has transformed bioprocess manufacturing by improving efficiency, reducing costs, and minimizing contamination risks.

From HEK293 scalability limitations to freeze-thaw degradation and bag breakage losses, explore five underestimated challenges that routinely derail viral vector manufacturing at scale.

Innovative process solution provider Single Use Support continues to deliver strong organic growth, supported by an expansion in its employee base. With a successful year 2023 in the rear-view mirror, 2024 is already shaping up to be even better.

See how adopting the standardized and fully automated processes of Industry 4.0 can contribute to your cost efficiency, patient safety, and sustainability in pharmaceutical manufacturing.

Single-use technology is playing a large role in increasing flexibility and reducing contamination risks for the biopharmaceutical industry. Take a deeper look into all of the advantages and challenges.

In order to advance viral vectors like AAVs, there's a growing need for technologies and platforms that facilitate reliable and safe handling all the way from production to shipping and storage.

Take a closer look at the process of cryopreservation, which role it plays for cell banking, and which challenges have to be overcome to reach the successful cryopreservation of cells.

Compare sterilization methods for single use assemblies and determine which is best suited to meet the needs of your operations and final product.

Review important factors in cell viability and cell health and how this information is crucial to researchers and cGMP cell banking.

Learn about the crucial role vectors play in delivering genes, types of non-viral vectors, the challenges with non-viral vectors in gene therapy, and the advantages of lipid-based nanoparticles.

By following some of the best practices in freezing mRNA, you can effectively balance product quality, cost-effectiveness, process safety, and efficiency.

Single Use Support, leading provider of fluid management and freeze-thaw logistic solutions for the biopharmaceutical industry, is excited to announce its further expansion into the United States market.

Delve into the medical applications of lipid nanoparticles with a focus on their role in targeted drug delivery, particularly in cancer treatment, gene therapy, and vaccine development.

Take a look at how antibody drug conjugates are advancing oncology therapeutics and explore seven facts about them you probably didn't know.

While antibody drug conjugates (ADCs) are a promising alternative for cancer therapy, their high toxicity presents a lot of challenges for the scale-up and industrial production of ADCs.

Manufacturers at biotech and biopharma companies need help keeping up with continuously advancing novel treatments. Technologies that provide control over the freeze-thaw process offer solutions.

If you are looking for an alternative to spray drying for your bulk intermediates, there's a plate-based freezing and thawing system that may provide a controlled and uniform solution.

Check out adaptable and scalable single-use solutions and automated processes that improve efficiency, lower costs, and address human error and product loss in the pharmaceutical manufacturing process.

Learn about hybrid solutions for drug freezing and thawing, control over freezing and thawing of bottles, and how single-use bags support the start of a change in bioprocessing technology.

Explore advanced fluid management for cell culture freezing, cell banking and cell therapy.

Learn more about cold storage solution for valuable bulk drug substances at biomanufacturing facilities.

Learn more about the application of ADCs, the challenges of manufacturing them, and tools for handling them in closed systems without exposing them to the environment.

Learn more about the challenge of controlling cryogenic freezing, especially with liquid nitrogen, and some innovative solutions being presented.

Maintaining cell viability during fluid handling requires highly controlled filling operations. Explore these strategies and technologies that enable controlled, temperature-regulated filling.

Discover how controlled freezing minimizes cryoconcentration and protein denaturation in bulk drug substances. Learn about efficient, scalable freezing solutions for enhanced product stability.

Dive into the world of cold chain management for drug substances. Learn more about practical solutions for improving your cold chain handling and transport processes

Protect any single use bag with RoSS: Robust Storage and Shipping. The right material at the right place – what we can learn from oysters.

For any single use bag and any freezing infrastructure freeze your drug substance/product without worries! The right material at the right place – what we can learn from oysters. Tough protected & tamper evident! The tried and tested single-use bag gets its 100% secure and compact shell.