RNase Contamination – Is The Hype Real?

By David Seifert

RNase contamination is a silent adversary in the world of biopharmaceutical manufacturing, particularly for mRNA-based therapeutics. These ubiquitous enzymes can wreak havoc on RNA molecules, jeopardizing product stability and efficacy. In this article, we will examine the challenges posed by RNase contamination, exploring its sources, impacts, and the strategies employed to mitigate its detrimental effects.

From the manufacturing floor to the final product, RNase contamination can occur at various stages. Its presence can lead to reduced product yield, compromised quality, and increased production costs. This article sheds light on the specific challenges faced by manufacturers, including the difficulty of detecting and quantifying RNase contamination.

To combat this silent threat, manufacturers have implemented a range of solutions. From rigorous hygiene practices and sterilization techniques to the use of RNase inhibitors and certified RNase-free consumables, the industry is working tirelessly to ensure the integrity of RNA-based therapeutics.

Join us as we explore the battle against RNase contamination and discover the strategies that are shaping the future of RNA-based drug manufacturing.