JON O'CONNELL ARTICLES
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![cancer cell screening, disease treatment medical-GettyImages-2176920684]( "Inside March Biosciences' CD5-Targeting CAR-T Approach")
Inside March Biosciences' CD5-Targeting CAR-T Approach5/4/2026Fratricide is one of the key reasons T-cell therapies targeting T-cell malignancies have faltered. March's approach aims to solve that with its MB-105 candidate.
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![Hygiene and virus prevention-GettyImages-1225240860]( "The Stepwise Path Lilly Mapped From Paper To Digital Logbooks")
The Stepwise Path Lilly Mapped From Paper To Digital Logbooks4/30/2026Eli Lilly and Company started at the front lines, on the shop floor gathering operator input, when switching from paper to digital logbooks.
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![research technician, multipipette, genetic laboratory-gettyimages-1326441039]( "Validating Candel's BLA-Ready Analytics Profile")
Validating Candel's BLA-Ready Analytics Profile4/22/2026The adenovirus/prodrug company discusses in-house assay development and the validation work to confirm CQAs like potency and cell line integrity.
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![Eli Lilly Headquarters-GettyImages-1793099940]( "Lilly's Unified Mindset For A Global Parenteral and Device Manufacturing Network")
Lilly's Unified Mindset For A Global Parenteral and Device Manufacturing Network4/17/2026Eli Lilly and Company's one-team mindset aims to templatize facility design while remaining nimble enough to react to new manufacturing breakthroughs.
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![Autosampler gas chromatography-GettyImages-152956846]( "Dynamic Flux Analysis Offers Faster Metabolic Modeling Than DOE")
Dynamic Flux Analysis Offers Faster Metabolic Modeling Than DOE2/27/2026By continuously analyzing spent media, researchers can estimate reaction rates at regular time points, providing a granular view of cell metabolism.
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![Laboratory research equipment-GettyImages-2168490868]( "A Novel In Vitro Glycosylation Approach For Difficult PTMs")
A Novel In Vitro Glycosylation Approach For Difficult PTMs2/19/2026Post-translational modifications of membrane proteins have been historically challenging. Research shows how an in vitro approach brings stability and predictability.
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![Stainless steel tanks, pipes, fitting-GettyImages-1218955365]( "A Peek Into Novo Nordisk's Sustainable Facility Construction Mindset")
A Peek Into Novo Nordisk's Sustainable Facility Construction Mindset2/18/2026Fill/finish operations are famously resource-heavy. Nonetheless, Novo set out to achieve ambitious environmental goals with its $4.1 billion project in North Carolina.
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![doctor Holding a Chronometer-GettyImages-91516833]( "Using Carbon Nanotubes To Pinpoint Optimal Harvest Time in Bioprocessing")
Using Carbon Nanotubes To Pinpoint Optimal Harvest Time in Bioprocessing2/18/2026Cell-free expression systems confound the moment of peak expression. These nanosensors signal through crude lysate for process optimization and endpoint monitoring.
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![Fungal Hyphae and Sporangium Under Microscope-GettyImages-2217760991]( "This Industrial Fungus Has Protein Expression Promise For Pharma")
This Industrial Fungus Has Protein Expression Promise For Pharma2/12/2026Trichoderma reesei is well characterized for industrial uses. A Finnish research group is exploring it for pharmaceutical protein expression.
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![System Monitoring, Controlling Program, technology development laboratory-GettyImages-1214112033]( "New ISPE Framework Targets Uncertainty In Pharma's AI Deployment")
New ISPE Framework Targets Uncertainty In Pharma's AI Deployment1/29/2026International Society for Pharmaceutical Engineering members developed the guide to offer a risk-based framework for evaluating, implementing, and maintaining AI systems.
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![Bioreactor-GettyImages-801080370]( "The Module Type Package Wants All Your Equipment To Start Talking")
The Module Type Package Wants All Your Equipment To Start Talking12/11/2025A forthcoming ISPE guide uses case studies to aid in the design of plug-and-play process skids with implications for every step in the manufacturing process continuum.
Jon O'Connell
Jon O’Connell is the Executive Editor for BioProcess Online, a leading publication within the Life Science Connect family. With a career rooted in high-stakes journalism, Jon oversees critical content focused on biopharmaceutical manufacturing and clinical trial supply. His editorial lens covers the entire biologics lifecycle—from early-stage process development to final packaging—with a steadfast mission to streamline industry workflows and accelerate the delivery of life-saving therapies to patients. An award-winning journalist, Jon’s work has been recognized by the Keystone Society of Professional Journalists and the Pennsylvania AP Managing Editors. In 2020, he was awarded a prestigious National Press Foundation fellowship to study cancer research, further deepening his technical expertise in the oncology space. Whether hosting the Business of Biotech podcast or moderating industry-shaping Q&As, Jon remains dedicated to bridging the gap between complex science and actionable business intelligence.