DOWNSTREAM PROCESSING FEATURED ARTICLES
Aeras announces that it has signed an agreement with GlaxoSmithKline Vaccines, S.A. (GSK) to jointly advance the clinical development of an investigational tuberculosis (TB) vaccine containing GSK’s proprietary M72 antigen and AS01E adjuvant.
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Galapagos Receives EUR2.5 Million IWT Grant For IBD Research
Galapagos NV (Euronext: GLPG) announced today that it has been awarded a EUR2.5 million grant from the Flemish agency for Innovation by Science and Technology (IWT) for inflammatory bowel disease (IBD) research and development. The goal of this 2.5-year project is to identify new therapeutic compounds for future treatment of IBD patients.
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![Klyachkoneuron]( "Fragile X Makes Brain Cells Talk Too Much")
Fragile X Makes Brain Cells Talk Too MuchThe most common inherited form of mental retardation and autism, fragile X syndrome, turns some brain cells into chatterboxes, scientists at Washington University School of Medicine in St. Louis report. By Michael C. Purdy
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![ChromeleonScreen]( "Thermo Fisher Scientific Introduces Data System To Unite Chromatography And Mass Spectrometry")
Thermo Fisher Scientific Introduces Data System To Unite Chromatography And Mass SpectrometryThermo Fisher Scientific Inc., the world leader in serving science, recently introduced the next generation of its gold-standard Chromeleon chromatography data system (CDS), which now supports mass spectrometry along with mainstream front-end separation techniques in the same software package.
DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES
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Improving DNA Removal from Bioprocess Purification Processes
Many new biological drug products produced using recombinant DNA technology, such as monoclonal antibodies, are produced in cell culture. Because therapeutic proteins such as monoclonal antibodies are produced in cell culture, impurities can result from the host cells, or cell substrates. By 3M Purification Inc.
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An Automated Profiling Application For G9a Histone Methyltransferase And Bromodomain Proteins
Due to several findings, G9a and BET bromodomain proteins have become the target for numberous drug discovery projects. In this study, we describe a novel, cell-based assay platform that uses the robust, yet simple Enzyme Fragment Complementation (EFC) Technology.
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![Bio-rad]( "Selecting The Optimal Resins For The Process Purification Of Native And Recombinant Proteins")
Selecting The Optimal Resins For The Process Purification Of Native And Recombinant ProteinsNative and recombinant proteins are used in a variety of applications ranging from drug discovery to target validation to high-throughput screening. Due to this, large-scale protein production and purification have become major necessities in industrial settings.
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Met One Sensors Resistant To Vaporous Hydrogen Peroxide (VHP) Pharmaceutical manufacturers often require an aseptic production environment to minimize the presence of microbes and their potential contamination of the manufactured product.
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Efficiency Test Of ReadyToProcess™ Columns
ReadyToProcess™ columns are prepacked, prequalified, and presanitized process chromatography columns suited for purification of biopharmaceuticals (e.g., proteins, vaccines, plasmids, and viruses) for clinical phase I and II studies. ReadyToProcess columns are available with several media at different volumes (1, 2.5, 10, and 20 L).
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![Fig 1]( "Cultivation Of CHO Suspension Cells And SEAP Expression")
Cultivation Of CHO Suspension Cells And SEAP ExpressionThis application note describes the cultivation of CHO suspension cells in the wave-mixed Thermo Scientific HyPerforma Rocker Bioreactor with a maximum working volume of 5 L.
DOWNSTREAM PROCESSING PRODUCTS
Macro-Prep hydrophobic interaction chromatography (HIC) media are methacrylate-based, 50 µm beads used for protein, polypeptide, enzyme, and nucleic acid purification.
Time-to-clinic and time-to-market are two key factors in successful biopharmaceutical development.
DOWNSTREAM PROCESSING MULTIMEDIA
Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.
Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.