Downstream Processing Solution Center Downstream Processing Solution Center

DOWNSTREAM PROCESSING FEATURED ARTICLES

Fragile X Makes Brain Cells Talk Too Much
Fragile X Makes Brain Cells Talk Too Much

The most common inherited form of mental retardation and autism, fragile X syndrome, turns some brain cells into chatterboxes, scientists at Washington University School of Medicine in St. Louis report. By Michael C. Purdy

  • AdvantaPure®’s BioPharm Tubing And Single-Use Systems To Be Featured At Upcoming Fall Shows
    AdvantaPure®’s BioPharm Tubing And Single-Use Systems To Be Featured At Upcoming Fall Shows High purity tubing manufacturer AdvantaPure will exhibit at three trade shows for the pharmaceutical and bioprocess industries this fall. Each exhibition will provide the company with opportunities to meet with customers and prospects, answer questions, and promote the continuing adoption of single use products.
  • MMRGlobal Targets Phase 3 Biotech Companies To Combine Assets With Life Sciences Group

    MMRGlobal, Inc. (OTCBB: MMRF) today announced that through its wholly owned subsidiary, MMR Life Sciences Group, the Company plans on exploiting its pipeline of biotech assets by facilitating a partnership or other joint venture with a privately held biotech company that has completed its Phase 2 clinical trials and is in the process of beginning Phase 3.

  • Rapid Single Molecule Haplotyping A technical poster from Fluidigm Europe entitled 'Rapid single-molecule haplotyping in patients with sickle cell disease' reports upon the pioneering work of Dr Stephen Menzel and his fellow researchers at Kings College (London), School of Medicine.
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DOWNSTREAM PROCESSING WHITE PAPERS AND CASE STUDIES

  • Assessment Of New Developments In ADCC Assays

    With many of the existing patents covering antibody therapies set to expire in the next few years, the development of biologic therapeutics similar to the original drug (biosimilars) has become increasingly important. 

  • High Efficiency Separations At Any pH Or Mobile Phase
    High Efficiency Separations At Any pH Or Mobile Phase

    The Hamilton PRP-C18 is a new column designed to provide high efficiency reversed phase separations over an extended column life in nearly any mobile phase or pH.

  • Endotoxin Removal From Bench To Process Scale
    Endotoxin Removal From Bench To Process Scale

    Endotoxin or lipopolysaccharides (LPS) are highly toxic components of the cell wall of Gram-negative bacteria and are often present in significant amounts in bacterial cell expression systems such as E.coli.

  • A Disposable Valve For Process Chromatography

    This case study discusses the need for a fully automated, disposable chromatography system which was PLC controlled and designed for use in a cGMP environment. The required applications for the chromatography system included contamination removal, and concentration and purification of biologically derived proteins used in the production of research and clinical materials. 

  • Are You Into Biosimilars?
    Are You Into Biosimilars?

    Biosimilars are considered to be one of the fastest growing sectors of the pharmaceutical industry.

  • Considerations For The Development Of Stable Cell Lines From Parental Lines Quality standards are often difficult to properly anticipate across today’s global regulatory environments. In recent years, quality expectations have increased due to public demand and to government regulation. This article explores some important considerations when determining quality standards for parental cell lines.
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DOWNSTREAM PROCESSING PRODUCTS

PBL Identification And Custom Bespoke Chromatography Adsorbent Design Services PBL Identification And Custom Bespoke Chromatography Adsorbent Design Services

Since 1987 PBL has been pioneering the design, development and manufacture of affinity purification technology for lab-scale and industrial-scale bioprocessing. With over 25 years experience and success in the development of bioseparation products and design of new custom adsorbents, PBL is a world leader in its field.

Our goal is to provide you with a fully validated, bespoke chromatography adsorbent and all associated process conditions for your target biomolecule, resulting in maximum yield and purity while employing the minimum number of process steps.

Centrifugation: Allegra X-12 Centrifuge Centrifugation: Allegra X-12 Centrifuge
ARIES™ Smart Balance Rotor automatically corrects for imbalance.
PBS 80 Air-Wheel Bioreactor PBS 80 Air-Wheel Bioreactor

The PBS 80 all-in-one, stand-alone system is the most advanced single-use bioreactor currently available. The PBS 80 is the smallest, most efficient, easy-to-use, disposable 80 liter bioreactor in the biopharmaceutical industry.

Membrane Filters For Sterile Filtration And Clarification Membrane Filters For Sterile Filtration And Clarification
The ULTA™ family of normal flow filtration products is specifically designed to support a wide range of biopharmaceutical liquid filtration applications.
ELx405™ Select Deep Well Microplate Washer ELx405™ Select Deep Well Microplate Washer
From the leaders in microplate washing, BioTek introduces the world’s first deep well microplate washer that aspirates and dispenses into 96- and 384-well plates ≤50 mm in height.
FunctionMAX™ TiterEnhancer, AGT™ Additive FunctionMAX™ TiterEnhancer, AGT™ Additive

FunctionMAX™ TiterEnhancer uses a new technology to combine key nutrients in a highly concentrated, functional additive that is designed to reinforce existing feeds and amplify the productivity of standard high cell density fed-batch platforms. 

Cell Culture Tools For Biological Sciences Cell Culture Tools For Biological Sciences

Our upstream process equipment including bioreactors, roller culture equipment and incubators. Small scale consumables and glassware contained in this section include, staining ware, tissue grinders, spinner flasks, and magnetic stirrers.

AlbuPure® – Premium Product for Albumin Fusion Purification AlbuPure® – Premium Product for Albumin Fusion Purification

AlbuPure®, developed in collaboration with Novozymes and manufactured exclusively by PBL, is our premium product for the purification of a wide range of recombinant albumin fusion proteins.

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DOWNSTREAM PROCESSING MULTIMEDIA

Optima X Series Ultracentrifuge: Energy Efficient Technology, Real-Time Data Tracker

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Large Scale Automated Depth Filtration Video

The Zeta Plus Encapsulated System product portfolio for single-use depth filtration has been expanded to include the Model# 16EZC Multi-Round Holder.

GE Healthcare At AAPS: FTA DMPK Cards
Jim Robbins and Julie Hilton Demonstrate GE Healthcare's Whatman Indicating FTA DMPK cards.
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DOWNSTREAM PROCESSING INDUSTRY NEWS

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