DOWNSTREAM PROCESSING FEATURED ARTICLES

Nearly 1,000 Medicines In Development To Help Patients In Their Fight Against Cancer

America’s biopharmaceutical research companies are testing 981 medicines and vaccines to fight the many types of canceraffecting millions of patients worldwide, according to a report released today by the Pharmaceutical Research and Manufacturers of America (PhRMA).

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DOWNSTREAM PROCESSING PRODUCTS

Water for Injection (WFI) Quality Water is the most suitable water available for producing cell culture media, reconstitution of biochemical reagents, and as a final rinse water for critical applications. WFI Quality Water meets both EP and USP grade specifications and is 0.1µm sterile filtered at time of fill.

Proyield Soy SE70M-UF is protein hydrolysate derived from soy protein concentrate by enzymatic hydrolysis. The enzymes used for digestion are from non-animal sources. Proyield Soy SE70M-UF has been ultrafiltered to reduce endotoxin.

Mixed-mode chromatography resin is a top tier selection for the manipulation, purification and handling of molecules; providing an unmatched level of separation properties and resolution. The combination of cation exchange resin and metal affinity resin properties, allows multimodal chromatography to provide an access route for biomolecules to separate and the use of alternative chromatographic methods make these biomolecules seem homogenous.

The ATF™ System was originally designed for perfusion processes in mammalian cell culture, using hollow fiber filters to achieve an efficient cell separation with low shear and allowing robust large scale manufacturing.

Cellulosic, polypropylene or glass fiber depth filter media clarify or retain agglomerates and macromolecules. Protect downstream membrane filters and columns. Multiple inlet / outlet connections including sanitary tri-clamp, hose barbs, quick connectors, elbows or NPT. Disc for small volume, up to full sized Cartridges and capsules for process scale operations.

ZenPure designs, mold-manufactures and injects its own filter components. Engineering, product development and filter production under ISO standards facilitate full quality audit and traceability to meet the highest industry standards. Validation support documentation is available for appropriate products.

ARC Sensors are the complete solution: innovative premium quality sensors with a robust, direct, and standard interface to the PLC. Hamilton ARC Sensors send a 4-20 mA signal directly to an analog process control system while delivering at the same time the power of digital sensor management.

Capto S, Capto Q and Capto DEAE are, respectively, strong cation, strong anion and weak anion exchange media for packed bed chromatography that increase speed and throughput in capture and intermediate purification.

PRP-X300 is a polymeric column packing for the separation of alcohols and organic acids.

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Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

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