DOWNSTREAM PROCESSING FEATURED ARTICLES
PBS Biotech Launches Single-Use Bioreactor For Development Of New Vaccines And Biosimilars
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Researchers' Sequencing Of Human and Monkey Malaria Genomes Reveals Challenges, Opportunities In Battle Against Parasite
Genetic variability revealed in malaria genomes newly sequenced by two multi-national research teams points to new challenges in efforts to eradicate the parasite, but also offers a clearer and more detailed picture of its genetic composition, providing an initial roadmap in the development of pharmaceuticals and vaccines to combat malaria.
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Genetic Markers ID Second Alzheimer's Pathway
Researchers at Washington University School of Medicine in St. Louis have identified a new set of genetic markers for Alzheimer’s that points to a second pathway through which the disease develops. By Jim Dryden
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Spinnovation Biologics Spedia-NMR Gains Momentum In Client Adoption Spinnovation, Nijmegen, The Netherlands: Increasing demand for Spedia-NMR technology from Spinnovation Biologics is expected to continue.
DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES
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Best Practices For Process Scale Column Packing Of CHT™ Ceramic Hydroxyapatite Media
CHT ceramic hydroxyapatite media require specific considerations during process-scale chromatography packing due to high specific gravity, rapid settling rate, and sensitivity to mechanical shear.
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Protein A Alternatives: Mixed Mode Resins For High Throughput mAb Feedstocks
Mixed mode resins can serve as an alternative to protein A in intermediate processing. Implementation of mixed mode resins can reduce water required for filtration and time for column loading.
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A Purification Strategy For Clinical-Grade Monoclonal Antibody
mAbs are currently the most important class of therapeutic proteins. Advances in upstream process technologies have led to tremendous improvement of mAb titers in mammalian cell culture.
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Important Parameters For Packing Nuvia HR-S Resin At Process Scale
Process-scale production typically involves more than one column. The packing quality of each column affects the efficiency of the whole workflow and is an important validation criterion.
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Agilent Microarray Grant Application Support White Paper This guide offers an overview of Agilent’s microarray and SureSelect product offerings with ordering details to assist researchers with the details of grant submission.
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The Challenge of Measuring Total Organic Carbon In Modern Pharmaceutical Water Systems
Total Organic Carbon (TOC) is one of the quality attributes defined in the European and USA pharmacopoeias for pharmaceutical waters. Modern water treatment systems can deliver such high purity water that TOC levels can be consistently close to zero and very difficult to measure with any accuracy. This paper discusses some of the challenges when using TOC analysers to demonstrate pharmacopoeial TOC level compliance for modern water systems in the light of the ICH Q2 document from the International Conference on Harmonisation.