DOWNSTREAM PROCESSING FEATURED ARTICLES

MorphoSys Receives First Patent On Novel Antibody Platform Ylanthia In The US

MorphoSys AG (FSE: MOR; Prime Standard Segment, TecDAX) today announced that the US Patent and Trademark Office (USPTO) has granted the first patent covering the Company's latest antibody platform Ylanthia, which became commercially available for existing and new partners in 2012.

  • Scientists Find A New Way To Boost Common Cancer Drugs

    Shutting down a specific pathway in cancer cells appears to improve the ability of common drugs to wipe those cells out, according to new research from scientists at Fox Chase Cancer Center, published in the January issue of Cancer Discovery.

  • FDA Approves New Seasonal Influenza Vaccine Made Using Novel Technology

    The U.S. Food and Drug Administration recently announced that it has approved Flublok, the first trivalent influenza vaccine made using an insect virus (baculovirus) expression system and recombinant DNA technology. Flublok is approved for the prevention of seasonal influenza in people 18 through 49 years of age.

  • Evotec Acquires Cell Culture Service GmbH

    Evotec AG recently announced the acquisition of all shares in Cell Culture Service GmbH (CCS), a Hamburg-based company which supports the cell culture needs of a world-wide customer base of biotech and Pharmaceutical companies.

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DOWNSTREAM PROCESSING PRODUCTS

Proyield Soy SE50MAF-UF is a protein hydrolysate derived from soy protein by enzymatic hydrolysis. The enzymes used for digestion are from non-animal sources. Proyield Soy SE50MAF-UF has been ultrafiltered to reduce endotoxin.

Sterilizing grade 0.04um, 0.1um, 0.2um hydrophilic PES membrane filters plus other micron ratings. Single layer or double layer PES and with optional prefilter layers to extend on-stream life. Gamma compatible and suitable PVDF alternative. Mold injected capsules with multiple inlet / outlet options including sanitary ‘T’ clamps, hose barbs, quick sanitary connectors, elbows and threads. Almost any combination of connecting inlet or outlet is possible with over 30 options. Full validation supporting documents are available. Ideal for tube sets and hook up to bioreactors, fermenters, biocontainer, biobags, wave bags or single use fermenters.

ZenPure’s in-company mold design and injection capabilities, filter production and quality assurance facilitate manufacturing audit and product traceability that meet the highest industry standards.

Resin are designed specifically for intermediate purification steps that remove host-cell contaminants from partially purified targets using strong or weak hydrophobic interactions. Methacrylate-based beads for protein and nucleic acid purification using hydrophobic interactions are available for purifying compounds that have weak or strong hydrophobic regions.

Cellulosic, polypropylene or glass fiber depth filter media clarify or retain agglomerates and macromolecules. Protect downstream membrane filters and columns. Multiple inlet / outlet connections including sanitary tri-clamp, hose barbs, quick connectors, elbows or NPT. Disc for small volume, up to full sized Cartridges and capsules for process scale operations.

ZenPure designs, mold-manufactures and injects its own filter components. Engineering, product development and filter production under ISO standards facilitate full quality audit and traceability to meet the highest industry standards. Validation support documentation is available for appropriate products.

Baumann 85000 sanitary pinch valves are intended for use with up to 3/4 inch O.D. pharmaceutical grade tubing. They are designed to couple FIELDVUE™ digital valve controller intelligence with a linear actuator and tube shell.

New C-Flex® ULTRA pump tubing is the latest addition to the C-Flex family of thermoplastic elastomer (TPE) tubing. Specifically designed to meet the critical demands of the biopharmaceutical industry, C-Flex® ULTRA outperforms all other TPE materials on the market today.

Natrix HD Membranes offer a breakthrough in membrane architecture that will forever change downstream purification. Available in two chemistries: Q (strong anion exchange) and Sb (strong cation exchange and hydrophobic group).

Recirculating hollow fiber systems have been used for a long time with mixed results. The recurring problem with these and all other cell retention systems is the difficulty in scaling up and staying sterile.

DOWNSTREAM PROCESSING MULTIMEDIA

Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

DOWNSTREAM PROCESSING INDUSTRY NEWS