DOWNSTREAM PROCESSING FEATURED ARTICLES

12MML012_bioreactor_jpopp_LR.jpg Ultrasound Idea: Prototype NIST/CU Bioreactor Evaluates Engineered Tissue While Creating It

Researchers at the National Institute of Standards and Technology (NIST) have developed a prototype bioreactor—a device for culturing cells to create engineered tissues—that both stimulates and evaluates tissue as it grows, mimicking natural processes while eliminating the need to stop periodically to cut up samples for analysis.

DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • Global Biochemical Profiling For Bioprocess Optimization

    It is widely understood that the production phase of bioprocessing can have a significant impact on the overall profitability of the biopharmaceutical.

  • Applications And Integration Of Hydrogen Peroxide Vapor For Biotech/Bioprocess

    The increase in size and scale of bio-processing is presenting a new challenge. Traditional methods of sterilisation, to maintain clean facilities, are becoming difficult to deploy in a controlled and regulatory compliant way. By Richard Lucas, Ph.D., Bioquell UK Ltd.

  • Turning Data Into Information

    As biopharmaceutical manufacturing has evolved from small-scale lab production in small flasks to massive commercial production in deep-tank bioreactors, an avalanche of production data has evolved to support it. From individual unit operation skids to distributed control systems and enterprise resource planning tools, biomanufacturing today is buried by the sheer quantity of data coming in from the manufacturing floor.

  • Biomanufacturing Debottlenecking And Process Optimization

    Optimizing biomanufacturing is particularly challenging because of variability and complexity associated with the sharing of finite and interdependent resources. By BIO-G

  • A Purification Strategy For Clinical-Grade Monoclonal Antibody

    mAbs are currently the most important class of therapeutic proteins. Advances in upstream process technologies have led to tremendous improvement of mAb titers in mammalian cell culture. 

  • Biomanufacturing Complexity

    This white paper addresses one of the most serious challenges facing biomanufacturing professionals today - how to understand and then deal with the extreme complexity associated with biotechnology manufacturing.

DOWNSTREAM PROCESSING PRODUCTS

ARTeSYN arterial process valves can be arranged in a multitude of orientations. They can be arranged with individual straight through valves for quick assembly and break down or in multi-valve arrays to facilitate even the lowest hold up volume requirements.

Cross- Flow Filtration mineral (inorganic) membranes and systems for bioprocessing and separation of biomolecules (e.g. monoclonal antibodies); especially for UF/DF filtration step in downstream processing.
Recirculating hollow fiber systems have been used for a long time with mixed results. The recurring problem with these and all other cell retention systems is the difficulty in scaling up and staying sterile.

In an effort to push science forward, WHEATON is manufacturing  a new line of membrane driven flasks for high density cell culture. The flasks are designed to enhance small scale bio-production for antibody and protein generation.

Bio-Simplex™ Sterile Disposable Centrifuge Tubes are ready-to-use cost-effective single-use containers designed for general biopharmaceutical manufacturing applications such as preculture and sampling. 

All Hamilton General Use Housings/Armatures have an integrated electrode protection design to prevent possible damage of the electrode membrane due to solid components in the sample.

Magnosphere™ is a superparamagnetic particle for in vitro diagnostics and bio research applications.

The electro-optical module EOM-O2-mini is a precise OEM solution for non-invasive oxygen sensor spots. Assembled according to ISO 9001:2000 they deliver certified quality.

DOWNSTREAM PROCESSING MULTIMEDIA

Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

DOWNSTREAM PROCESSING INDUSTRY NEWS