DOWNSTREAM PROCESSING FEATURED ARTICLES
Innate Pharma SA (
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![image]( "Targeting Sugars In The Quest For A Vaccine Against HIV — The Virus That Causes AIDS")
Targeting Sugars In The Quest For A Vaccine Against HIV — The Virus That Causes AIDSAs a step toward designing the first effective vaccine against HIV, the virus that causes AIDS, scientists are reporting new insights into how a family of rare, highly potent antibodies bind to HIV and neutralize it — stop it from infecting human cells.
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FDA Approves New Seasonal Influenza Vaccine Made Using Novel Technology
The U.S. Food and Drug Administration recently announced that it has approved Flublok, the first trivalent influenza vaccine made using an insect virus (baculovirus) expression system and recombinant DNA technology. Flublok is approved for the prevention of seasonal influenza in people 18 through 49 years of age.
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Ablynx And Its Partner Advance Nanobody Candidate ALX-0751 In Pre-Clinical Development
Ablynx [Euronext Brussels: ABLX] today announced that they have advanced the Nanobody(®) candidate ALX-0751, together with Merck Serono, a division of Merck KGaA, Darmstadt, Germany, into pre-clinical development in the field of oncology.
DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES
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![Determination Of kLa Values Of Single-Use Bioreactors]( "Determination Of kLa Values Of Single-Use Bioreactors")
Determination Of kLa Values Of Single-Use BioreactorsBecause single use bioreactors offered by manufacturers vary in parameters critical for oxygen transfer, they are often not comparable to each other and to conventional glass and stainless steel vessels.
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![450x300 drug model-inside protein molecule]( "Important Parameters For Packing Nuvia HR-S Resin At Process Scale")
Important Parameters For Packing Nuvia HR-S Resin At Process ScaleProcess-scale production typically involves more than one column. The packing quality of each column affects the efficiency of the whole workflow and is an important validation criterion.
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Biomanufacturing Supply Chains
This white paper examines the major issues with biopharmaceutical supply chains and how to balance inventory and risk optimally in the network.
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![Bill whitford]( "Continuous Biomanufacturing: 10 Reasons Sponsors Hesitate")
Continuous Biomanufacturing: 10 Reasons Sponsors HesitateThe industry is abuzz with talk about continuous biomanufacturing (CB), and its virtues have been well described. Here we will look at some of the barriers or concerns perceived to limit its value to the industry. Justified or not, quite a few concerns have been expressed regarding the implementation of this new, rather disruptive technology.
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Sani-Tech® Ultra White Paper
For several years, pharmaceutical manufacturing professionals have increasingly stated concerns about material leachables and extractables and their impact on the products they produce. Fluid transfer systems that include flexible tubing have been at the forefront of this discussion.
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![ANAKTAstart]( "Automating Protein Purification Processes Achieves Reliable Results And Reproducibility")
Automating Protein Purification Processes Achieves Reliable Results And ReproducibilityÄKTA start is an easy-to-use, reliable protein purification system. In this application note it is described how Erica, a post-doctoral researcher, used ÄKTA start to purify GST-tagged protein using a predefined method template, a GSTrap FF column, and a Frac30 fraction collector.
DOWNSTREAM PROCESSING PRODUCTS
Time-to-clinic and time-to-market are two key factors in successful biopharmaceutical development.
Resin are designed specifically for intermediate purification steps that remove host-cell contaminants from partially purified targets using strong or weak hydrophobic interactions. Methacrylate-based beads for protein and nucleic acid purification using hydrophobic interactions are available for purifying compounds that have weak or strong hydrophobic regions.
ÄKTA avant™ is a preparative chromatography system designed for fast and secure development of scalable methods and processes.
DOWNSTREAM PROCESSING MULTIMEDIA
Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.
Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.