DOWNSTREAM PROCESSING FEATURED ARTICLES
Phenomenex Creates Centralized, Interactive Resource For Kinetex Core-Shell HPLC / UHPLC Column Users
Phenomenex Inc., a global leader in the research and manufacture of advanced technologies for the separation sciences, introduces the "Kinetex Experience" - an online center for the many tools available to users of the company's flagship core-shell HPLC/UHPLC columns and those interested in learning about core-shell technology.
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NGM Enters Agreement With Janssen To Discover And Develop Novel Therapeutics For Diabetes
NGM Biopharmaceuticals, Inc. announced recently that it has signed a worldwide agreement with Janssen Pharmaceuticals, Inc. to discover and develop novel therapeutics for the potential treatment of Type 2 diabetes and other metabolic diseases.
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DSM Announces Patent Grants For Proprietary XD Biomanufacturing Technology
DSM Biologics focuses on optimizing biopharmaceutical manufacturing through its unique set of technologies. The XD technology is an important building block in DSM’s vision for the future of biopharmaceutical manufacturing.
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![ketamine_MEG_scans]( "Brain Signal IDs Responders To Fast-Acting Antidepressant")
Brain Signal IDs Responders To Fast-Acting AntidepressantScientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say National Institutes of Health researchers.
DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES
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![A Purification Strategy For Clinical-Grade Monoclonal Antibody]( "A Purification Strategy For Clinical-Grade Monoclonal Antibody")
A Purification Strategy For Clinical-Grade Monoclonal AntibodymAbs are currently the most important class of therapeutic proteins. Advances in upstream process technologies have led to tremendous improvement of mAb titers in mammalian cell culture.
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Comparison Of Five Cell Culture Media Demonstrating CHO Cell Culture Growth In Batch Or Fed-Batch Process For Commercial Operations
This case study details a two month, four phase project to design chemically-defined feed media that improved two simulated batch processes utilizing products by SAFC, Life Technologies, Thermo Fisher Scientific, and Irvine Scientific. By Mark C. Arjona, Evan R. Horowitz, Alex A. Jurisch, Jenny Y. Bang, Tom Fletcher, Irvine Scientific
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Rapid Chemically-Defined Feed Media Development to Improve Simulated Cell Culture Processes
Implementing an optimized feed medium may be the most effective alternative for modifications to the growth medium in an existing process.
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Biomanufacturing Flexibility
This white paper from BIO-G looks at how to create flexible, agile manufacturing facilities to respond to the current glut of biomanufacturing capacity and industry consolidation. Future proofing these facilities for higher titers and multiple product lines is also explored.
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White Paper: Computrac® Moisture Analysis Made Simple When people aren’t feeling their best they often turn to medicine for relief from the symptoms that are associated with being ill. The public trusts that the products by pharmaceutical companies will not only make them feel better but will also not have harmful side effects.
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Protein A Alternatives: Mixed Mode Resins For High Throughput mAb Feedstocks
Mixed mode resins can serve as an alternative to protein A in intermediate processing. Implementation of mixed mode resins can reduce water required for filtration and time for column loading.
DOWNSTREAM PROCESSING PRODUCTS
Bio-Beads SM-2 nonpolar polystyrene adsorbents are analytical grade, neutral macroporous polymeric beads for use in hydrophobic interaction chromatography.
Capto Core 700 is a multimodal chromatography medium designed for purification of large proteins or viruses in vaccine processes.
A proven method for confirming protein purity and yield without the need for gel staining steps. Stain-free gels provide visual confirmation of protein purity and yield by gel electrophoresis in less than 30 minutes. Stain-free technology is perfect for drug discovery, drug development, and method development for preclinical research.
CHT is a leading purification medium of biomolecules in today’s demanding downstream process industry. Its mixed-mode support offers unique selectivities and often separates biomolecules that appear homogeneous with other chromatographic methods. The diverse binding capabilities of CHT for host cell proteins, leached protein A, antibody dimers and aggregates, nucleic acids, and viruses allow its use at any stage from initial capture to final polishing.
DOWNSTREAM PROCESSING MULTIMEDIA
Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.
Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.