DOWNSTREAM PROCESSING FEATURED ARTICLES

Selexys Pharmaceuticals Completes $23M Equity Financing And Signs Agreement With Global Pharmaceutical Company

Selexys Pharmaceuticals, Corp., announced today that it has successfully completed a $23 million Series A equity financing, led by MPM Capital. Additionally, Selexys entered into an agreement with Novartis Pharmaceuticals whereby Novartis has been granted an exclusive option to acquire Selexys and its lead asset, the anti-P-selectin antibody SelG1, following the successful completion of a Phase 2 clinical study in patients with sickle cell disease.

  • 3 Critical Considerations For Cell Therapy Manufacturing
    3 Critical Considerations For Cell Therapy Manufacturing

    While autologous cell therapies offer promise in the way of patient treatment, manufacturing them is a complex process requiring thorough understanding of the cell type(s) that a company will be providing as therapy. When it comes to ensuring the successful manufacturing of a cell therapy drug, Ross Tubo, chief scientific officer at Vericel Corporation, says there are three critical areas where particular attention should be paid.

  • Life Science Insights From An Industry Visionary
    Life Science Insights From An Industry Visionary

    When Parrish Galliher first founded Xcellerex, now part of GE Healthcare, he referred to the business idea as “bugs on wheels” because unlike traditional stainless steel biologic manufacturing facilities which can’t be built quickly, easily changed or moved, his concept for the FlexFactory allowed manufacturers to build and/or modify manufacturing capacity quickly and at far less cost. Moreover, no longer did companies have to take three to four years to build a plant that could manufacture only one product, but could build structures that could be changed quickly from manufacturing one product to another. The idea was, at the time, quite disruptive to our conservative industry where, according to Galliher, it can take close to a decade for companies to adopt new technology. Galliher confided that in the early days of starting Xcellerex in December 2002, he struggled to get funding for the business.

  • Is The Single-Use Standardization Debate Slowing Down Adoption?
    Is The Single-Use Standardization Debate Slowing Down Adoption?

    Without single-use standardization, the customization required to build a single-use facility may prevent a full-scale adoption of single-use technology. So how do we move forward? Maybe, by taking a look back.

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DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • Connection Technology Advances Closed System Processing
    Connection Technology Advances Closed System Processing

    The global demand for new biologics and vaccines, combined with the growing emergence of biosimiliars, is challenging drugmakers to re-evaluate their processes and seek ways to make them more flexible, reliable, and cost-effective. By John Boehm, Colder Products Company

  • Determination Of kLa Values Of Single-Use Bioreactors
    Determination Of kLa Values Of Single-Use Bioreactors

    Because single use bioreactors offered by  manufacturers vary in parameters critical for oxygen transfer, they are often not comparable to each other and to conventional glass and stainless steel vessels.

  • Dissolved Ozone Measurements: Installation And Calibration According To ASTM D7677-11

    In the last three decades Ozone has become a very important and efficient tool to achieve high quality pharmaceutical grade water. This paper will address two main topics that are critical for the effective use of ozone within the water processes of the life science industry. By Georges Schmidt, Hach Lange Sàrl, Geneva, Switzerland

  • Filtration Trials With SAFC® EX-CELL® CD Hydrolysate Fusion

    Following the launch of the EX-CELL CD Hydrolysate Fusion, SAFC conducted a study with partner company Sartorius Stedim Biotech. EX-CELL CD Hydrolysate Fusion is the first fully chemically defined media supplement of its kind in the industry. By SAFC

  • White Paper: Computrac® Moisture Analysis Made Simple When people aren’t feeling their best they often turn to medicine for relief from the symptoms that are associated with being ill. The public trusts that the products by pharmaceutical companies will not only make them feel better but will also not have harmful side effects.
  • Automated pH Adjustment In An Intelligent Single-Use Mixing Platform
    Automated pH Adjustment In An Intelligent Single-Use Mixing Platform

    Most pH adjustment process steps in single-use biomanufacturing require manual manipulation of the product and vessel, including off-line sampling, pH measurement, and the addition of acid and base.

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DOWNSTREAM PROCESSING PRODUCTS

Bio-Simplex™ Sterile Disposable Centrifuge Tubes Bio-Simplex™ Sterile Disposable Centrifuge Tubes

Bio-Simplex™ Sterile Disposable Centrifuge Tubes are ready-to-use cost-effective single-use containers designed for general biopharmaceutical manufacturing applications such as preculture and sampling. 

Ion Exchange Resin Ion Exchange Resin

A wide selection of ion exchange resin is available in various particle sizes, ionic forms, and purity ranges to offer a variety of purification solutions for process applications. Nuvia ion exchange resins are a family of best-in-class ion exchangers built with exceptionally high capacities and excellent purification capabilities, providing process developers more flexibility and higher productivity. The Macro-Prep are rigid macroporous hydrophilic resin meet the demands of process-scale applications. Chemically and mechanically stable, the resin operate well at low and medium pressures.

Proyield Soy SE50MAF-UF Proyield Soy SE50MAF-UF
Proyield Soy SE50MAF-UF is a protein hydrolysate derived from soy protein by enzymatic hydrolysis. The enzymes used for digestion are from non-animal sources. Proyield Soy SE50MAF-UF has been ultrafiltered to reduce endotoxin.
Parsum IPP 70-S: Particle Sizing Probe Parsum IPP 70-S: Particle Sizing Probe

Compact, lightweight and easy to install, the Parsum IPP-70-S probe delivers in situ, real-time size and velocity measurements for solid particles up to 6000 µm in size. The IPP 70 continuously tracks a large variety of PSD parameters making it ideal for endpoint detection, process control, process optimization and real time quality control for a range of applications.

Ion Exchangers: Capto™ S, Capto Q, & Capto DEAE Ion Exchangers: Capto™ S, Capto Q, & Capto DEAE

Capto S, Capto Q and Capto DEAE are, respectively, strong cation, strong anion and weak anion exchange media for packed bed chromatography that increase speed and throughput in capture and intermediate purification.

PreDictor RoboColumn: Prepacked Columns Of Chromatography Media PreDictor RoboColumn: Prepacked Columns Of Chromatography Media

PreDictor RoboColumn units are mini columns prepacked with GE Healthcare BioProcess chromatography media. When used together with a robotoic system such as Tecan, PreDictor RoboColumn units perform automated parallel screening of media and process conditions with minimal sample consumption. 

Benchtop SIP Bioreactor Systems: CelliGen® 510 Benchtop SIP Bioreactor Systems: CelliGen® 510

The CelliGen 510 is a compact sterilizable-in-place cell culture system ideal for pilot to small scale production processes. The modular design features a wide variety of standard options allowing this system to be flexible enough to meet most process requirements.

FlexCessory™ End-Ported Biocontainer Hanging Stand FlexCessory™ End-Ported Biocontainer Hanging Stand

Meissner has developed a line of accessories to complement our One-Touch® single-use systems portfolio called FlexCessories™. The products in this portfolio are designed to facilitate the secure deployment and streamlined implementation of single-use systems.

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DOWNSTREAM PROCESSING MULTIMEDIA

Optima X Series Ultracentrifuge: Energy Efficient Technology, Real-Time Data Tracker

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Large Scale Automated Depth Filtration Video

The Zeta Plus Encapsulated System product portfolio for single-use depth filtration has been expanded to include the Model# 16EZC Multi-Round Holder.

GE Healthcare At AAPS: FTA DMPK Cards

Jim Robbins and Julie Hilton Demonstrate GE Healthcare's Whatman Indicating FTA DMPK cards.

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DOWNSTREAM PROCESSING INDUSTRY NEWS

More Downstream Processing Industry News