DOWNSTREAM PROCESSING FEATURED ARTICLES

New Monoclonal Antibody Developed That Can Target Proteins Inside Cancer Cells

Researchers have discovered a unique monoclonal antibody that can effectively reach inside a cancer cell, a key goal for these important anticancer agents, since most proteins that cause cancer or are associated with cancer are buried inside cancer cells.

DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • Single-Use Connections Advance Aseptic Processing

    John Boehm discusses how single-use connections advance aseptic processing and create increased process flexibility and reliability while reducing costs.

  • Biomanufacturing Flexibility

    This white paper from BIO-G looks at how to create flexible, agile manufacturing facilities to respond to the current glut of biomanufacturing capacity and industry consolidation. Future proofing these facilities for higher titers and multiple product lines is also explored.

  • Global Biochemical Profiling For Bioprocess Optimization

    It is widely understood that the production phase of bioprocessing can have a significant impact on the overall profitability of the biopharmaceutical.

  • Cultivation Of Human CAP Cells: Evaluation Of Scale-Down Capabilities

    The following application note illustrates how the DASbox Mini Bioreactor System combined with the BioBLU 0.3c single-use vessels supports bioprocess development in human cell culture.

  • Managing Cell-Based Potency Assays: From Development To Lifecycle Maintenance

    Characterization of a biological product — which includes the determination of physicochemical properties, biological activity, immunochemical properties, purity and impurities — is necessary to establish the safety and efficacy profile of a given product (ICH Q6B).  By Dr. Weihong Wang, manager, Molecular and Cell Biology, Eurofins Lancaster Laboratories

  • A Disposable Valve For Process Chromatography

    This case study discusses the need for a fully automated, disposable chromatography system which was PLC controlled and designed for use in a cGMP environment. The required applications for the chromatography system included contamination removal, and concentration and purification of biologically derived proteins used in the production of research and clinical materials. 

DOWNSTREAM PROCESSING PRODUCTS

Hydrophilic media and depth filters. Cellulosic, Diatomaceous earth + cellulose, GF, polyproylene and nano fiber disposable capsules or cartridges. For clarification, prefiltration or to protect columns. Many different inlet / outlet connections, with or without vents and drains. SIP / Autoclavable. Specify when gamma stability is required.

AseptiQuik® STC Connectors integrate the AseptiQuik® sterile connector and the Steam-Thru® II SIP connector, giving manufacturers even greater flexibility for hybrid stainless steel and single-use processing. 

High volume labs require simple, durable solutions to their centrifugation needs. Beckman Coulter’s Allegra® Series general purpose, benchtop centrifuges serve the needs of these labs by saving time, offering ease-of-use, and providing reliable design for endurance under the most exacting standards.

SoftGrip pipettes routinely receive the highest user satisfaction score of 10 on 11 different aspects of a pipette, including plunger and eject forces, weight, diameter, and texture.

Hydrophilic or hydrophobic membrane filter capsules and cartridges for sterilizing liquid or gas. More than 20 different inlet / outlet connections, with or without vents and drains. SIP / Autoclavable. Specify when gamma stability is required.

A proven method for confirming protein purity and yield without the need for gel staining steps. Stain-free gels provide visual confirmation of protein purity and yield by gel electrophoresis in less than 30 minutes. Stain-free technology is perfect for drug discovery, drug development, and method development for preclinical research.

Sani-Tech® offers a complete line of high-purity, non-metallic sanitary processing systems and related components, including tubing and fittings, valves, flow measurement components and sight gauges, and sanitary adapters, as well as fabrication equipment for field installation and small-scale bench-top systems for research and process development. 

Complement your gene expression analysis with LOH studies. Confirm your SNP analysis results by sequencing. Combine MLPA genomic results with quantitative gene expression for the full story.

DOWNSTREAM PROCESSING MULTIMEDIA

Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

DOWNSTREAM PROCESSING INDUSTRY NEWS