DOWNSTREAM PROCESSING FEATURED ARTICLES
A new biofuel production process created by Michigan State University researchers produces 20 times more energy than existing methods.
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Crucell And Scripps Research Discover And Describe Broad-Spectrum Antibodies Against Influenza B, A Crucial Link In Development Of Universal Flu Therapies And Vaccine
In a landmark discovery, researchers from Crucell Holland B.V. and The Scripps Research Institute, recently announced the identification of the first human monoclonal antibodies that appear capable of disabling all influenza B viruses.
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FlexFill Single-Use Transfer Assembly Meissner introduces its new FlexFill single-use biocontainer transfer assembly. The assembly is ideally suited for applications requiring fast and dependable aseptic transfer of small liquid process volumes.
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Newfound Gene May Help Bacteria Survive In Extreme Environments
In the days following the 2010 Deepwater Horizon oil spill, methane-eating bacteria bloomed in the Gulf of Mexico, feasting on the methane that gushed, along with oil, from the damaged well. The sudden influx of microbes was a scientific curiosity: Prior to the oil spill, scientists had observed relatively few signs of methane-eating microbes in the area. By Jennifer Chu, MIT
DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES
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USP <787> Small Volume Testing With Liquid Particle Counters
By their very nature, biological therapeutics are not only expensive to manufacture but are often produced in small volumes.
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Economic Analysis Of Single-Use Tangential Flow Filtration For Biopharmaceutical Applications Prior to creating an accurate economic model for TFF, a thorough understanding of the process where the TFF is used is needed. A process model is a valuable tool when properly executed and it must accurately include all critical aspects of the purification process. By Michael LaBreck, Mark Perreault, Novasep
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Biological Contamination Events In Isolators: What Lessons Can Be Learned?
Microbiological deviation and biological contamination events have been observed in pharmaceutical isolators including those used in production, sterility test and pharmacy aseptic services. By James Drinkwater, Bioquell UK Process & Compliance Director
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Important Parameters For Packing Nuvia HR-S Resin At Process Scale
Process-scale production typically involves more than one column. The packing quality of each column affects the efficiency of the whole workflow and is an important validation criterion.
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Important Considerations For Implementing A Single-Use Biomanufacturing Strategy
Recent trends in biomanufacturing technology and the biopharmaceutical market are supporting the increased adoption of single-use (SU) manufacturing systems. On the demand-side, the biopharma industry is focusing on niche and rare diseases with smaller patient populations, resulting in the need for smaller, more agile biomanufacturing capacity. By Jodi M. Zobrist and Nicole W. O'Brien, Ph. D., Gallus Biopharmaceuticals, LLC
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How CHT Ceramic Hydroxyapatite Works Application Note
CHT ceramic hydroxyapatite is a versatile chromatography support used for separation of biological molecules as diverse as polyclonal and monoclonal antibodies, antibody fragments, enzymes, nucleic acids, and membrane proteins. By Paul Ng, Jie He, and Andrew Cohen, Bio-Rad Laboratories, Inc., Hercules, CA 94547