DOWNSTREAM PROCESSING FEATURED ARTICLES

extractables in single-use Standardized Extractables Testing Advances Single Use Adoption

The Standardized Extractables Testing Protocol For Single-Use Systems In Biomanufacturing written by BPOG members last year establishes a foundation from which to create a standardized approach to extractables testing. However, since its release, there have been some questions and discussions about how to effectively implement the protocol.

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DOWNSTREAM PROCESSING PRODUCTS

BioTek’s Take3™ and Take3™ Trio Micro Volume Plates are designed to increase the functionality of your BioTek microplate spectrophotometer, multi-mode or Hybrid reader by decreasing the sample size required to a mere 2 µL.

Capto Core 700 is a multimodal chromatography medium designed for purification of large proteins or viruses in vaccine processes.

WHEATON’s selection of chromatography vials and accessories offers quality, value and reliability. WHEATON chromatography vials are designed for trouble-free operation in most autosamplers.

The APM is a next generation fluid management solution for single use process systems allowing you to modulate and control flow without having to use your fingers as the control valve.

This is an exciting platform technology for cell cultivation. It is a highly versatile process which permits great increases in cell and product concentrations as compared to Fed Batch processing.

The Emphaze Hybrid Purifier is a new single-use clarifying device containing a multi-mechanism all synthetic Q-functional anion exchange media integrated with a fine particle, bioburden reduction membrane. The anion exchange media is comprised of a quaternary amine hydrogel supported by a fine fiber nonwoven scaffold. A combination of 3M technology platforms enables the hyperfunctionalization of a high purity polypropylene nonwoven with a covalently attached, thermally stable, water soluble polymer; the functional polymer accounts for roughly two-thirds of the mass of the anion exchange media. The bioburden reduction membrane is a highly asymmetric, high loading capacity polyamide membrane which has nine zones of decreasing pore size spanning a roughly 20X range and terminating with a 0.2 μm bioburden reduction rated pore size.

Pure-Fit® SC is an innovative new connective technology that makes it possible to create true sterile connections anywhere – even outside the clean room environment.

BalanCD® CHO Feed 1 is a chemically-defined protein-free feed medium designed to provide cell culture nutrients for fed-batch applications in conjunction with BalanCD® CHO Growth A.

DOWNSTREAM PROCESSING MULTIMEDIA

Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

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