DOWNSTREAM PROCESSING FEATURED ARTICLES

Aseptika Ltd Launches Time Saving Single-Use Bioreactor Sampler
Aseptika Ltd launches Time Saving Single-use Bioreactor Sampler Aseptika Ltd, an innovator in the development of clean technologies for the Biopharmaceutical industry, has launched their Bioreactor Sampler

DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • Managing Cell-Based Potency Assays: From Development To Lifecycle Maintenance

    Characterization of a biological product — which includes the determination of physicochemical properties, biological activity, immunochemical properties, purity and impurities — is necessary to establish the safety and efficacy profile of a given product (ICH Q6B).  By Dr. Weihong Wang, manager, Molecular and Cell Biology, Eurofins Lancaster Laboratories

  • Avoiding Drug Shortages With Microbial Detection

    Over the past year, critical drug shortages used to treat a host of life-threatening illnesses have been making headlines. Microbial contamination has been cited as a major contributor to the shortage, yet the prevailing practices to ensure the safety of drugs have been slow to change. In most cases, quality assurance practices safeguarding the drug making environment continue to rely on periodic air and a culturing method from a prior century. By Aric Meares, President and CEO, BioVigilant

  • Sani-Tech® Ultra White Paper

    For several years, pharmaceutical manufacturing professionals have increasingly stated concerns about material leachables and extractables and their impact on the products they produce. Fluid transfer systems that include flexible tubing have been at the forefront of this discussion. 

  • Compound Profiling And Toxicity

    Utilizing a systems approach to drug discovery has generated a multitude of high affinity compounds for various classes of molecular targets with different degrees of disease state validation.

  • Comparison Of Five Cell Culture Media Demonstrating CHO Cell Culture Growth In Batch Or Fed-Batch Process For Commercial Operations

    This case study details a two month, four phase project to design chemically-defined feed media that improved two simulated batch processes utilizing products by SAFC, Life Technologies, Thermo Fisher Scientific, and Irvine Scientific. By Mark C. Arjona, Evan R. Horowitz, Alex A. Jurisch, Jenny Y. Bang, Tom Fletcher, Irvine Scientific

  • Removal Of Host Cell Proteins During Monoclonal Antibody Purification

    Protein A chromatography is a widely used and highly successful method of purifying recombinant monoclonal antibodies. However, since Protein A has high affinity for antibodies, harsh conditions such as low pH are often required to elute monoclonal antibodies from Protein A affinity columns. By 3M Purification Inc

DOWNSTREAM PROCESSING PRODUCTS

From the leaders in microplate washing, BioTek introduces the world’s first deep well microplate washer that aspirates and dispenses into 96- and 384-well plates ≤50 mm in height.

The Avanti® J-HC High Capacity Centrifuge provides you with a complete solution for batch bioprocessing. A maximum of 9 Liters can be spun at speeds of 5,000 rpm and 7,480 x g for greater sample throughput. This allows processing of up to 36 Liters per hour when harvesting bacteria. Enhanced operator safety is provided with disposable HarvestLine System Liners.

Conductivity sensors measure the ability of a solution to conduct a current. The higher the concentration of ions in the solution, the higher the conductivity, which is measured in microSiemens (mS).

MicroRNAs (miRNAs) are small non-coding RNAs that regulate the activity of specific mRNA targets and play crucial roles in a wide variety of biological processes, including gene expression, development, proliferation, differentiation, and apoptosis.

Magnosphere™ is a superparamagnetic particle for in vitro diagnostics and bio research applications.

Our upstream process equipment including bioreactors, roller culture equipment and incubators. Small scale consumables and glassware contained in this section include, staining ware, tissue grinders, spinner flasks, and magnetic stirrers.

Amsphere™ A3 is a next generation Protein A chromatography resin for advanced protein separation in downstream processing of therapeutic antibodies manufacturing. With high capacity resin, Amsphere™ A3 has an overall improved process robustness, flow characteristics, optimized impurity removal, productivity and resin lifetime.

Sani-Tech® Ultra represents the next generation in ultra-pure platinum-cured silicone tubing. Features like ultra-low extractables and longer pump life were engineered into Ultra by the experienced materials scientists of Saint-Gobain Performance Plastics to meet the stringent requirements of the biopharmaceutical market.

DOWNSTREAM PROCESSING MULTIMEDIA

Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

DOWNSTREAM PROCESSING INDUSTRY NEWS