DOWNSTREAM PROCESSING FEATURED ARTICLES

121107_monuki_c228px.jpg New Cell Type Developed For Possible Treatment Of Alzheimer's And Other Brain Diseases

UC Irvine researchers have created a new stem cell-derived cell type with unique promise for treating neurodegenerative diseases such as Alzheimer’s.

DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • Biomanufacturing Flexibility

    This white paper from BIO-G looks at how to create flexible, agile manufacturing facilities to respond to the current glut of biomanufacturing capacity and industry consolidation. Future proofing these facilities for higher titers and multiple product lines is also explored.

  • Efficiencies Of Natural Convection In Passive Pallet Shippers

    Bulk transportation of temperature sensitive pharmaceuticals and biologics has become a common practice due to complex global supply chains. By Iftekhar Ahmed, Ben VanderPlas, and Stu Krupnick

  • Turning Data Into Information

    As biopharmaceutical manufacturing has evolved from small-scale lab production in small flasks to massive commercial production in deep-tank bioreactors, an avalanche of production data has evolved to support it. From individual unit operation skids to distributed control systems and enterprise resource planning tools, biomanufacturing today is buried by the sheer quantity of data coming in from the manufacturing floor.

  • Micro-Volume Determination Of Labeling Efficiency In A Standard Microplate Reader

    A variety of methods and reagents have been developed to efficiently label biomolecules. By Peter J. Brescia, Applications Scientist,  BioTek Instruments, Inc.

  • Single-Use Connections Advance Aseptic Processing

    John Boehm discusses how single-use connections advance aseptic processing and create increased process flexibility and reliability while reducing costs.

  • Important Considerations For Implementing A Single-Use Biomanufacturing Strategy

    Recent trends in biomanufacturing technology and the biopharmaceutical market are supporting the increased adoption of single-use (SU) manufacturing systems. On the demand-side, the biopharma industry is focusing on niche and rare diseases with smaller patient populations, resulting in the need for smaller, more agile biomanufacturing capacity. By Jodi M. Zobrist and Nicole W. O'Brien, Ph. D., Gallus Biopharmaceuticals, LLC

DOWNSTREAM PROCESSING PRODUCTS

High volume labs require simple, durable solutions to their centrifugation needs. Beckman Coulter’s Allegra® Series general purpose, benchtop centrifuges serve the needs of these labs by saving time, offering ease-of-use, and providing reliable design for endurance under the most exacting standards.

Freeze drying is a potentially damaging process, especially to labile materials such as proteins or living organisms. Depending on the product type damage can occur at various stages of the process including freezing, drying and heating.

Protein A based affinity chromatography is the industry standard for the capture of monoclonal antibodies (MAbs) in downstream processing.

The APM is a next generation fluid management solution for single use process systems allowing you to modulate and control flow without having to use your fingers as the control valve.

The DoverPac® Bag In/Bag Out (BIBO) containment system is a family of contained transfer designs for multiple processes. The primary components for this validated operation consist of multiple groove canisters, docking interface hardware, and softgoods in either continuous liner form or discreet liners.

Recirculating hollow fiber systems have been used for a long time with mixed results. The recurring problem with these and all other cell retention systems is the difficulty in scaling up and staying sterile.

This is an exciting platform technology for cell cultivation. It is a highly versatile process which permits great increases in cell and product concentrations as compared to Fed Batch processing.

Our syringes are handmade with an unmatched attention to detail. The manufacturing process and quality assurance procedures ensure that every syringe we sell will provide superior accuracy and precision as well as cycle life.

DOWNSTREAM PROCESSING MULTIMEDIA

Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

DOWNSTREAM PROCESSING INDUSTRY NEWS