DOWNSTREAM PROCESSING FEATURED ARTICLES
-
Ultrasound Idea: Prototype NIST/CU Bioreactor Evaluates Engineered Tissue While Creating It
Researchers at the National Institute of Standards and Technology (NIST) have developed a prototype bioreactor—a device for culturing cells to create engineered tissues—that both stimulates and evaluates tissue as it grows, mimicking natural processes while eliminating the need to stop periodically to cut up samples for analysis.
-
Brooks' Single-Use REMP Tubes Support Optimization Of Automated Serum And Plasma Storage
Brooks Life Science Systems, a division of Brooks Automation, Inc. a leading worldwide provider of automation solutions for compound and biological sample storage and management, announced recently that Karolinska Institute Biobank (KI Biobank) is successfully using Brooks’ REMP single-use heat sealed sample tubes to secure the long-term storage of plasma, serum and urine samples in its automated biorepositories.
-
New Gene Mutations Linked To ALS And Nerve Cell Growth Dysfunction
Researchers have linked newly discovered gene mutations to some cases of the progressive fatal neurological disease amyotrophic lateral sclerosis - ALS, also known as Lou Gehrig's disease.
DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES
-
Micro-Volume Determination Of Labeling Efficiency In A Standard Microplate Reader
A variety of methods and reagents have been developed to efficiently label biomolecules. By Peter J. Brescia, Applications Scientist, BioTek Instruments, Inc.
-
Optimized Purity And Recovery Of A Monoclonal Antibody Using Mixed-Mode Chromatography Media
Monoclonal antibodies (mAbs) remain a predominant class of therapeutic protein products on the market because of their wide range of applications in disease treatment and diagnosis. Over the years, upstream technology advancements have helped improve the titer of target antibodies, from merely 1 g/L two decades ago to 10–13 g/L in fed-batch processes and up to 25 g/L in perfusion cultures today (Gronemeyer et al. 2014).
-
USP <787> Small Volume Testing With Liquid Particle Counters
By their very nature, biological therapeutics are not only expensive to manufacture but are often produced in small volumes.
-
Improving Aggregate Removal From mAb Feed Using Cation Exchange Chromatography
Researchers in the field of chromatography have required ever more sophisticated and selective methods for removing aggregates from the monomer.
-
Determination Of kLa Values Of Single-Use Bioreactors
Because single use bioreactors offered by manufacturers vary in parameters critical for oxygen transfer, they are often not comparable to each other and to conventional glass and stainless steel vessels.
-
CD69 Expression On Activated Lymphocytes Is Stable In Streck's Cyto-Chex® BCT
The purpose of this study was to determine if the activation marker, CD69, is preserved and stable in whole blood samples collected in Cyto-Chex® BCT. Previous studies have demonstrated CD marker stability of whole blood samples collected in Cyto-Chex BCT for up to 7 days when stored at room temperature (18-22°C). By Jodi Alt, Ph.D