DOWNSTREAM PROCESSING FEATURED ARTICLES
Scientists from VIB, KU Leuven, UGent and Harvard have succeeded in reconstructing DNA and proteins from prehistoric yeast cells. This made it possible to determine how genes developed and evolved into their current form over more than 100 million years.
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![8619351639_3956745910_b]( "Antibody Evolution Could Guide HIV Vaccine Development")
Antibody Evolution Could Guide HIV Vaccine DevelopmentObserving the evolution of a particular type of antibody in an infected HIV-1 patient, a study spearheaded by Duke University, including analysis from Los Alamos National Laboratory, has provided insights that will enable vaccination strategies that mimic the actual antibody development within the body.
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New 'Binary Technology' Boosts Plasmid DNA Purification Efficiency and Throughput The Aurum™ family of plasmid DNA purification systems is designed to significantly increase speed and consistency, from the highest-throughput 96-well applications through small-scale column studies.
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![CentTubeGroupUnflat]( "Announcing High Quality Borosilicate Glass Centrifuge Tubes")
Announcing High Quality Borosilicate Glass Centrifuge Tubes Chemists are finding the optimal centrifuge tubes they need at Kimble Chase, the largest manufacturer of laboratory glassware products in the world.
DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES
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Automated Bioluminescent ADCC Reporter Bioassay Using Bioengineered Jurkat Cells
Pharmaceutical companies are increasingly exploring new biologic and biosimilar products, and thus increasing monoclonal antibody (mAb) immunotherapeutic research. By Tracy Worzella, Promega Corporation and Brad Larson, Applications Department, BioTek Instruments, Inc.
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Materials Of Construction For Biopharmaceutical Water Systems
Stainless steels are uniquely qualified for bioprocessing applications not only because of their long service life, availability, and fabricability, but also because they are non-corroding, non-contaminant, can be polished to very smooth finishes, are strong and rigid, can withstand heat and chemical sterilization treatments, and are easily welded. By Michelle M. Gonzalez
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![Bacteria 450x300]( "Selecting The Optimal Resins For Endotoxin Depletion In Process Purification")
Selecting The Optimal Resins For Endotoxin Depletion In Process PurificationA guide to effectively remove endotoxins with versatile process resins.
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Rapid Chemically-Defined Feed Media Development to Improve Simulated Cell Culture Processes
Implementing an optimized feed medium may be the most effective alternative for modifications to the growth medium in an existing process.
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![Determination Of kLa Values Of Single-Use Bioreactors]( "Determination Of kLa Values Of Single-Use Bioreactors")
Determination Of kLa Values Of Single-Use BioreactorsBecause single use bioreactors offered by manufacturers vary in parameters critical for oxygen transfer, they are often not comparable to each other and to conventional glass and stainless steel vessels.
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Comparability Of The Cell-Freeze® (Charter Medical) Freezing Bag To The Cryocyte™ (Baxter) Bag For Cryogenic Storage Of Human Hematopoietic Progenitor Cells Successful cryopreservation of hematopoietic progenitor cells (HPC) is dependent upon a number of factors, including the biopreservation media, freezing rates, and storage using sterile, cryogenically durable storage bags. The Cell-Freeze® cryogenic storage containers are 510(k) cleared for storage, preservation and transfer of hematopoietic progenitor stem cells (HPC’s). By Charter Medical, Ltd.
DOWNSTREAM PROCESSING PRODUCTS
Nuvia HR-S media is a new strong cation exchanger that has been optimized for particle size and chemistry that provides exceptional resolution and high recovery.
A wide selection of ion exchange resin is available in various particle sizes, ionic forms, and purity ranges to offer a variety of purification solutions for process applications. Nuvia ion exchange resins are a family of best-in-class ion exchangers built with exceptionally high capacities and excellent purification capabilities, providing process developers more flexibility and higher productivity. The Macro-Prep are rigid macroporous hydrophilic resin meet the demands of process-scale applications. Chemically and mechanically stable, the resin operate well at low and medium pressures.
Time-to-clinic and time-to-market are two key factors in successful biopharmaceutical development.
DOWNSTREAM PROCESSING MULTIMEDIA
Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.
Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.