DOWNSTREAM PROCESSING FEATURED ARTICLES

ry_2001 Paired Genes In Stem Cells Shed New Light On Gene Organization And Regulation

Whitehead Institute researchers have determined that DNA transcription, the process that produces messenger RNA (mRNA) templates used in protein production, also runs in the opposite direction along the DNA to create corresponding long noncoding RNAs (lncRNAs). By Nicole Giese Rura

DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • The Challenge of Measuring Total Organic Carbon In Modern Pharmaceutical Water Systems

    Total Organic Carbon (TOC) is one of the quality attributes defined in the European and USA pharmacopoeias for pharmaceutical waters. Modern water treatment systems can deliver such high purity water that TOC levels can be consistently close to zero and very difficult to measure with any accuracy. This paper discusses some of the challenges when using TOC analysers to demonstrate pharmacopoeial TOC level compliance for modern water systems in the light of the ICH Q2 document from the International Conference on Harmonisation.

  • A Purification Strategy For Clinical-Grade Monoclonal Antibody

    mAbs are currently the most important class of therapeutic proteins. Advances in upstream process technologies have led to tremendous improvement of mAb titers in mammalian cell culture. 

  • Sani-Tech® Ultra White Paper

    For several years, pharmaceutical manufacturing professionals have increasingly stated concerns about material leachables and extractables and their impact on the products they produce. Fluid transfer systems that include flexible tubing have been at the forefront of this discussion. 

  • Biological Contamination Events In Isolators: What Lessons Can Be Learned?

    Microbiological deviation and biological contamination events have been observed in pharmaceutical isolators including those used in production, sterility test and pharmacy aseptic services. By James Drinkwater, Bioquell UK Process & Compliance Director

  • Materials Of Construction For Biopharmaceutical Water Systems

    Stainless steels are uniquely qualified for bioprocessing applications not only because of their long service life, availability, and fabricability, but also because they are non-corroding, non-contaminant, can be polished to very smooth finishes, are strong and rigid, can withstand heat and chemical sterilization treatments, and are easily welded. By Michelle M. Gonzalez

  • Continuous Biomanufacturing: 10 Reasons Sponsors Hesitate

    The industry is abuzz with talk about continuous biomanufacturing (CB), and its virtues have been well described. Here we will look at some of the barriers or concerns perceived to limit its value to the industry. Justified or not, quite a few concerns have been expressed regarding the implementation of this new, rather disruptive technology. 

DOWNSTREAM PROCESSING PRODUCTS

Introducing the new Allegra X-14 Series. At 120 volts, it's a great alternative to the higher voltage Allegra X-15R. This benchtop centrifuge is convenient, hardworking, reliable, and will speed up your process, cycle after cycle.

Encompassing two leading-edge processes, multi-zone microporous membrane construction and Advanced Pleating Technolog (APT) design, LifeASSURE™ PSA Series filters offer robust 0.20 and 0.10 micron absolute-rated filtration and exceptionally long service life.

Baumann 85000 sanitary pinch valves are intended for use with up to 3/4 inch O.D. pharmaceutical grade tubing. They are designed to couple FIELDVUE™ digital valve controller intelligence with a linear actuator and tube shell.

STERIS Isomedix Services provides contract sterilization and microbial control services for single-use bioprocess systems used in the production of biopharmaceuticals and vaccines.

SoftGrip pipettes routinely receive the highest user satisfaction score of 10 on 11 different aspects of a pipette, including plunger and eject forces, weight, diameter, and texture.

Bio-Beads SM-2 nonpolar polystyrene adsorbents are analytical grade, neutral macroporous polymeric beads for use in hydrophobic interaction chromatography.

The first self-contained oxygen measurement in the popular 12 mm format similar to standard process and pH electrodes and classical sterilizable oxygen sensors. VisiFerm DO optical sensors demonstrate a number of substantial advantages because of a symbiosis of sensor and measurement amplifier- an intelligent sensor.

The S.U.F. is engineered for optimal oxygen mass transfer, mixing, and temperature control, and performs comparably to traditional stainless steel systems. Using traditional, fundamental engineering principles, scale-up and process development work is streamlined – offering you cost savings and efficiency. 
 

DOWNSTREAM PROCESSING MULTIMEDIA

Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

DOWNSTREAM PROCESSING INDUSTRY NEWS