DOWNSTREAM PROCESSING FEATURED ARTICLES

Virus Engineered To Express Melanin Offers New Possibilities To Diagnose And Treat Solid Tumor Cancers

In a study released today in Proceedings of the National Academy of Sciences (PNAS), entitled "Vaccinia virus mediated melanin production allows MR and optoacoustic deep tissue imaging and laser induced thermotherapy of cancer," scientists combined the natural imaging potential of melanin with recombinant Vaccinia viruses' ability to selectively enter and replicate within tumor cells.

DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • Optimized Purity And Recovery Of A Monoclonal Antibody Using Mixed-Mode Chromatography Media

    Monoclonal antibodies (mAbs) remain a predominant class of therapeutic protein products on the market because of their wide range of applications in disease treatment and diagnosis. Over the years, upstream technology advancements have helped improve the titer of target antibodies, from merely 1 g/L two decades ago to 10–13 g/L in fed-batch processes and up to 25 g/L in perfusion cultures today (Gronemeyer et al. 2014).

  • Examining Column Reproducibility During Method Development In Clinical Labs

    In this study demonstrates how the HSS T3 stationary phase is a reliable stationary phase, as three batches made over a five-year span provide comparable results.

  • Sani-Tech® Ultra White Paper

    For several years, pharmaceutical manufacturing professionals have increasingly stated concerns about material leachables and extractables and their impact on the products they produce. Fluid transfer systems that include flexible tubing have been at the forefront of this discussion. 

  • How CHT Ceramic Hydroxyapatite Works Application Note

    CHT ceramic hydroxyapatite is a versatile chromatography support used for separation of biological molecules as diverse as polyclonal and monoclonal antibodies, antibody fragments, enzymes, nucleic acids, and membrane proteins. By Paul Ng, Jie He, and Andrew Cohen, Bio-Rad Laboratories, Inc., Hercules, CA 94547

  • Guidelines For Proper Filtration And Delivery Of Samples To On-Line Process Analyzers

    Increasingly precise process control strategies, often linked to computer control, have accelerated the use of sophisticated on-line chemical composition analyzers in plant applications. Instruments such as gas and liquid chromatographs, ion chromatographs, laser optic instruments, atomic absorption instruments and specific ion analyzers, which were rarities in laboratories ten years ago, are now found routinely in plant settings. By Ken Perrotta, Division Engineering Manager

  • Top 10 Considerations When Selecting An Isolator Supplier

    While price is certainly an important reason for buying any piece of capital equipment, it is not always the top reason. There are important considerations to examine when selecting an isolator supplier.

DOWNSTREAM PROCESSING PRODUCTS

Recirculating hollow fiber systems have been used for a long time with mixed results. The recurring problem with these and all other cell retention systems is the difficulty in scaling up and staying sterile.

Time-to-clinic and time-to-market are two key factors in successful biopharmaceutical development.

Complement your gene expression analysis with LOH studies. Confirm your SNP analysis results by sequencing. Combine MLPA genomic results with quantitative gene expression for the full story.

The Aquasyn tank bottom valve is a reliable solution for your tank outlet needs, with its conical profile allows for complete drainability and the prevention of deadlegs or entrapment areas.

Proyield Cotton CNE50M-UF is a protein hydrolysate derived from cottonseed by enzymatic hydrolysis. The enzymes used for digestion are from non-animal sources. Proyield Cotton CNE50M-UF has been ultrafiltered to reduce endotoxin.

Sani-Tech® Ultra represents the next generation in ultra-pure platinum-cured silicone tubing. Features like ultra-low extractables and longer pump life were engineered into Ultra by the experienced materials scientists of Saint-Gobain Performance Plastics to meet the stringent requirements of the biopharmaceutical market.

Sartopure PP2 Cartridges were optimized for the wide range of prefiltration.

The Hamilton PRP™-C18 is a new HPLC column designed to provide high-efficiency, reversed-phase separations over an extended column life in nearly any mobile phase or pH.

DOWNSTREAM PROCESSING MULTIMEDIA

Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

DOWNSTREAM PROCESSING INDUSTRY NEWS