DOWNSTREAM PROCESSING FEATURED ARTICLES

RNA-Based Therapy Brings New Hope For An Incurable Blood Cancer
RNA-Based Therapy Brings New Hope For An Incurable Blood Cancer

Three thousand new cases of Mantle Cell Lymphoma (MCL), a form of blood cancer, appear in the United States each year. With a median survival span of only five to seven years, according to the Leukemia and Lymphoma Society, this disease is devastating, and new therapies are sorely needed.

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DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • Removal Of Host Cell Proteins During Monoclonal Antibody Purification

    Protein A chromatography is a widely used and highly successful method of purifying recombinant monoclonal antibodies. However, since Protein A has high affinity for antibodies, harsh conditions such as low pH are often required to elute monoclonal antibodies from Protein A affinity columns. By 3M Purification Inc

  • Strategies For Gamma Sterilization Of Pharmaceuticals

    A crucial step in pharmaceutical production is sterilization. There are many sterilization methods to choose from, such as steam, sterile filtration, ethylene oxide gas (EtO), electron beam (E-beam), and gamma radiation. Each technique has aspects that make it suitable or unsuitable for the sterilization of a particular product. By Ruth Garcia, Betty Howard, Rose LaRue, Glenn Parton, and John Walker, Steris Isomedix Services

  • Economic Analysis Of Single-Use Tangential Flow Filtration For Biopharmaceutical Applications Prior to creating an accurate economic model for TFF, a thorough understanding of the process where the TFF is used is needed. A process model is a valuable tool when properly executed and it must accurately include all critical aspects of the purification process. By Michael LaBreck, Mark Perreault, Novasep
  • The Challenge of Measuring Total Organic Carbon In Modern Pharmaceutical Water Systems
    The Challenge of Measuring Total Organic Carbon In Modern Pharmaceutical Water Systems

    Total Organic Carbon (TOC) is one of the quality attributes defined in the European and USA pharmacopoeias for pharmaceutical waters. Modern water treatment systems can deliver such high purity water that TOC levels can be consistently close to zero and very difficult to measure with any accuracy. This paper discusses some of the challenges when using TOC analysers to demonstrate pharmacopoeial TOC level compliance for modern water systems in the light of the ICH Q2 document from the International Conference on Harmonisation.

  • Biological Contamination Events In Isolators: What Lessons Can Be Learned?

    Microbiological deviation and biological contamination events have been observed in pharmaceutical isolators including those used in production, sterility test and pharmacy aseptic services. By James Drinkwater, Bioquell UK Process & Compliance Director

  • Rapid Separation Of Basic Drug Compounds Under Alkaline pH Conditions On pH-Stable, Short .C18 Column
    Rapid Separation Of Basic Drug Compounds Under Alkaline pH Conditions On pH-Stable, Short .C18 Column

    Mobile phase pH is a powerful tool in methods development, particularly for separation of neutral forms of amines or other organic bases under alkaline conditions. By Derek Jensen and Mark Carrier, Hamilton Company

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DOWNSTREAM PROCESSING PRODUCTS

Sterilizing Grade Filter Cartridges & Capsules: LifeASSURE™ SP Series Sterilizing Grade Filter Cartridges & Capsules: LifeASSURE™ SP Series

LifeASSURE SP series sterilizing grade filters and capsules are validated for absolute bacteria retention and provide reliable sterile filtration performance.

Beckman Coulter Centrifuge:  Allegra® Series General Purpose Centrifuges Beckman Coulter Centrifuge: Allegra® Series General Purpose Centrifuges

High volume labs require simple, durable solutions to their centrifugation needs. Beckman Coulter’s Allegra® Series general purpose, benchtop centrifuges serve the needs of these labs by saving time, offering ease-of-use, and providing reliable design for endurance under the most exacting standards.

Bioprocessing Data Logging and Control Software Bioprocessing Data Logging and Control Software

Data logging and control software from Eppendorf is the most user-friendly bioprocessing software ever developed; designed by the company who pioneered the industry's first PC-compatible software over two decades ago.

Sartopure GF Plus Depth Filters Sartopure GF Plus Depth Filters
Sartopure GF Plus absorptive depth filter are designed for removal of contaminates from biopharmaceutical fluids.
Single Channel Adjustable Volume Pipette Single Channel Adjustable Volume Pipette

SoftGrip pipettes routinely receive the highest user satisfaction score of 10 on 11 different aspects of a pipette, including plunger and eject forces, weight, diameter, and texture.

C-Flex® Ultra Pump Tubing C-Flex® Ultra Pump Tubing

New C-Flex® ULTRA pump tubing is the latest addition to the C-Flex family of thermoplastic elastomer (TPE) tubing. Specifically designed to meet the critical demands of the biopharmaceutical industry, C-Flex® ULTRA outperforms all other TPE materials on the market today.

Water-For-Injection Quality Water (WFI) Water-For-Injection Quality Water (WFI)

Water for Injection (WFI) Quality Water is the most suitable water available for producing cell culture media, reconstitution of biochemical reagents, and as a final rinse water for critical applications. WFI Quality Water meets both EP and USP grade specifications and is 0.1µm sterile filtered at time of fill.

DNA Methylation DNA Methylation
DNA methylation events are heritable modifications that regulate gene expression without altering the DNA sequence itself. They serve as regulatory mechanisms for a wide range of biological processes and genetic diseases, and irregular methylation patterns have been associated with certain cancers.
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DOWNSTREAM PROCESSING MULTIMEDIA

Optima X Series Ultracentrifuge: Energy Efficient Technology, Real-Time Data Tracker

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Large Scale Automated Depth Filtration Video

The Zeta Plus Encapsulated System product portfolio for single-use depth filtration has been expanded to include the Model# 16EZC Multi-Round Holder.

GE Healthcare At AAPS: FTA DMPK Cards

Jim Robbins and Julie Hilton Demonstrate GE Healthcare's Whatman Indicating FTA DMPK cards.

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DOWNSTREAM PROCESSING INDUSTRY NEWS

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