DOWNSTREAM PROCESSING FEATURED ARTICLES
GE Healthcare recently announced that biopharmaceutical company Nanotherapeutics, Inc. has selected GE Healthcare Life Sciences' FlexFactory biomanufacturing platform to perform a central role in its Advanced Development and Manufacturing (NANO-ADM) Center at Alachua, Florida, USA.
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![All Hands In]( "COVID-19 Consortium: Competitive Collab On A Plasma-Derived Therapy")
COVID-19 Consortium: Competitive Collab On A Plasma-Derived TherapyA host of global biopharma competitors are collaborating under the CoVIg-19 Plasma Alliance to secure enough convalescent plasma to produce an effective COVID-19 therapeutic at global scale. Takeda’s Dr. Thomas R. Kreil will present at the upcoming FDA/Xavier PharmaLink Conference.
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![1361387862155]( "Researchers Identify Variations In Four Genes That Are Associated With An Increased Risk Of Colorectal Cancer")
Researchers Identify Variations In Four Genes That Are Associated With An Increased Risk Of Colorectal CancerAn international research team co-led by cancer prevention researcher Ulrike “Riki” Peters, Ph.D., M.P.H., and biostatistician Li Hsu, Ph.D., at Fred Hutchinson Cancer Research Center has identified variations in four genes that are linked to an increased risk of colorectal cancer.
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![ketamine_MEG_scans]( "Brain Signal IDs Responders To Fast-Acting Antidepressant")
Brain Signal IDs Responders To Fast-Acting AntidepressantScientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say National Institutes of Health researchers.
DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES
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![BIOBlu.jpg]( "Cultivation Of Human CAP Cells: Evaluation Of Scale-Down Capabilities")
Cultivation Of Human CAP Cells: Evaluation Of Scale-Down CapabilitiesThe following application note illustrates how the DASbox Mini Bioreactor System combined with the BioBLU 0.3c single-use vessels supports bioprocess development in human cell culture.
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Biomanufacturing Supply Chains
This white paper examines the major issues with biopharmaceutical supply chains and how to balance inventory and risk optimally in the network.
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White Paper: Economic Analysis Of Single-Use Tangential Flow Filtration For Biopharmaceutical Applications Prior to creating an accurate economic model for TFF, a thorough understanding of the process where the TFF is used is needed. A process model is a valuable tool when properly executed and it must accurately include all critical aspects of the purification process. By Michael LaBreck, Mark Perreault, Novasep
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Micro-Volume Determination Of Labeling Efficiency In A Standard Microplate Reader
A variety of methods and reagents have been developed to efficiently label biomolecules. By Peter J. Brescia, Applications Scientist, BioTek Instruments, Inc.
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![Optimized Purity And Recovery Of A Monoclonal Antibody Using Mixed-Mode Chromatography Media]( "Optimized Purity And Recovery Of A Monoclonal Antibody Using Mixed-Mode Chromatography Media")
Optimized Purity And Recovery Of A Monoclonal Antibody Using Mixed-Mode Chromatography MediaMonoclonal antibodies (mAbs) remain a predominant class of therapeutic protein products on the market because of their wide range of applications in disease treatment and diagnosis. Over the years, upstream technology advancements have helped improve the titer of target antibodies, from merely 1 g/L two decades ago to 10–13 g/L in fed-batch processes and up to 25 g/L in perfusion cultures today (Gronemeyer et al. 2014).
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Comparison Of Five Cell Culture Media Demonstrating CHO Cell Culture Growth In Batch Or Fed-Batch Process For Commercial Operations
This case study details a two month, four phase project to design chemically-defined feed media that improved two simulated batch processes utilizing products by SAFC, Life Technologies, Thermo Fisher Scientific, and Irvine Scientific. By Mark C. Arjona, Evan R. Horowitz, Alex A. Jurisch, Jenny Y. Bang, Tom Fletcher, Irvine Scientific
DOWNSTREAM PROCESSING PRODUCTS
Resin are designed specifically for intermediate purification steps that remove host-cell contaminants from partially purified targets using strong or weak hydrophobic interactions. Methacrylate-based beads for protein and nucleic acid purification using hydrophobic interactions are available for purifying compounds that have weak or strong hydrophobic regions.
Our integrated single-use bioreactors are designed as complete out-of-the-box jacketed systems, each paired with an integrated controller and temperature control unit (TCU).
DOWNSTREAM PROCESSING MULTIMEDIA
Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.
Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.