DOWNSTREAM PROCESSING FEATURED ARTICLES

Waters And Dow Announce Major Breakthrough In Advanced Polymer Analysis At Pittcon

Waters Corporation recently unveiled several important new technologies at the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy, commonly known as Pittcon, the annual premier conference and exposition on laboratory science.

  • Combo Of Avastin, Second Drug Shows Promise Fighting Brain Cancer, Mayo Clinic Finds

    The drug bevacizumab, also known by the trade name Avastin, shrinks tumors briefly in patients with an aggressive brain cancer known as glioblastoma multiforme, but then they often grow again and spread throughout the brain for reasons no one previously has understood.

  • Laser Spotlight Reveals Machine 'Climbing' DNA

    The experiments, reported in this week's Science, use laser light to generate very bright patches close to single cells. When coupled with fluorescent tags this 'spotlight' makes it possible to image the inner workings of cells fast enough to see how the molecular machines inside change size, shape, and composition in the presence of DNA.

  • Repligen Acquires Bioprocessing Business Of Refine Technology

    Repligen Corporation announced recently that it has acquired the business of Refine Technology (“Refine”), including Refine’s Alternating Tangential Flow (“ATF”) System, a market-leading device used to significantly increase product yield during the fermentation step of the biologic drug manufacturing process.

DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • Protein A Alternatives: Mixed Mode Resins For High Throughput mAb Feedstocks

    Mixed mode resins can serve as an alternative to protein A in intermediate processing. Implementation of mixed mode resins can reduce water required for filtration and time  for column loading.
     

  • Chromatography Column Protection With 3M Purification LifeASSURE™ PLA Series Membrane Filters Protective, or guard, filters are often used in chromatography column purification steps to protect the column media from contaminants in the various fluids that come in contact with the column.
  • Biomanufacturing Supply Chains

    This white paper examines the major issues with biopharmaceutical supply chains and how to balance inventory and risk optimally in the network.

  • Compound Profiling And Toxicity

    Utilizing a systems approach to drug discovery has generated a multitude of high affinity compounds for various classes of molecular targets with different degrees of disease state validation.

  • Materials Of Construction For Biopharmaceutical Water Systems

    Stainless steels are uniquely qualified for bioprocessing applications not only because of their long service life, availability, and fabricability, but also because they are non-corroding, non-contaminant, can be polished to very smooth finishes, are strong and rigid, can withstand heat and chemical sterilization treatments, and are easily welded. By Michelle M. Gonzalez

  • The Challenge of Measuring Total Organic Carbon In Modern Pharmaceutical Water Systems

    Total Organic Carbon (TOC) is one of the quality attributes defined in the European and USA pharmacopoeias for pharmaceutical waters. Modern water treatment systems can deliver such high purity water that TOC levels can be consistently close to zero and very difficult to measure with any accuracy. This paper discusses some of the challenges when using TOC analysers to demonstrate pharmacopoeial TOC level compliance for modern water systems in the light of the ICH Q2 document from the International Conference on Harmonisation.

DOWNSTREAM PROCESSING PRODUCTS

The SPRIworks Fragment Library Systems have built-in size selection and prepare fragment libraries for all three major next generation sequencing platforms. SPRIworks Systems simplify and automate fragment library construction for the Illumina Genome Analyzers, Roche GS FLX DNA Sequencer and Life Technologies SOLiD Sequencers.
Recirculating hollow fiber systems have been used for a long time with mixed results. The recurring problem with these and all other cell retention systems is the difficulty in scaling up and staying sterile.

Resin are designed specifically for intermediate purification steps that remove host-cell contaminants from partially purified targets using strong or weak hydrophobic interactions. Methacrylate-based beads for protein and nucleic acid purification using hydrophobic interactions are available for purifying compounds that have weak or strong hydrophobic regions.

Encompassing two leading-edge processes, multi-zone microporous membrane construction and Advanced Pleating Technolog (APT) design, LifeASSURE™ PSA Series filters offer robust 0.20 and 0.10 micron absolute-rated filtration and exceptionally long service life.

LifeASSURE SP series sterilizing grade filters and capsules are validated for absolute bacteria retention and provide reliable sterile filtration performance.

LifeASSURE PNA series filters help bioprocess, pharmaceutical, biologicals, and diagnostic reagent processors meet high standards for microorganism and fine particle control. 

BioTek’s Take3™ and Take3™ Trio Micro Volume Plates are designed to increase the functionality of your BioTek microplate spectrophotometer, multi-mode or Hybrid reader by decreasing the sample size required to a mere 2 µL.

The QAII Station has been designed to ensure each tested dissolution apparatus conforms with mechanical specifications.

DOWNSTREAM PROCESSING MULTIMEDIA

Bioprocess With The Bozenhardts is back, with a fresh episode packed with advice from Herman and Erich on the selection of filling systems for biopharmas. Listen in as the Bozenhardts give us an update on the process, logistics, and administration trends that are informing filling system decisions today, and offer direction on making choices that will prepare you for the fast-advancing therapies of tomorrow.

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Bio-Rad now offers two very high capacity ion exchangers: Nuvia S, which can be used for capture and/or intermediate polishing; and Nuvia Q, which can be used for intermediate and/or final polishing.

DOWNSTREAM PROCESSING INDUSTRY NEWS