DOWNSTREAM PROCESSING FEATURED ARTICLES

Thallion And LFB Terminate Shigamabs Collaboration

Thallion Pharmaceuticals Inc. (TSX-V: TLN) ("Thallion") and LFB Biotechnologies ("LFB") today announced that they have reached an agreement on the termination of their Development and Licensing Agreement related to Thallion's Shigamabs® program.

  • Saint-Gobain Adds Large Clamps To Pure-Fit® Line

    New Pure-Fit® TCL accommodates large diameter and thick wall tubing applications. Saint-Gobain Performance Plastics has expanded its line of innovative tube clamps with the introduction of the new Pure-Fit® TCL large tube clamp.

  • Catalan Researchers Identify A Key Component Of Cell Division
    Catalan Researchers Identify A Key Component Of Cell Division

    A study by the Institute for Research in Biomedicine (IRB Barcelona) and the Center for Genomic Regulation (acronym in Catalan CRG) highlights the protein Nek9 as a decisive factor in cell division, a fundamental process for both the development of an organism and tissue maintenance. 

  • Singapore Single-Cell Research Center Opens Door For Asian Biological Discoveries

    Government officials, academic, and industry leaders gathered to celebrate the official opening of the Single-Cell Omics Centre (SCOC) in Singapore today. It is the first research centre in Asia exclusively dedicated to accelerating the understanding of how individual cells work, and how diagnosis and treatment might be enhanced through insight derived from single cells.

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DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • An Automated Profiling Application For G9a Histone Methyltransferase And Bromodomain Proteins

    Due to several findings, G9a and BET bromodomain proteins have become the target for numberous drug discovery projects. In this study, we describe a novel, cell-based assay platform that uses the robust, yet simple Enzyme Fragment Complementation (EFC) Technology.

  • Important Considerations For Implementing A Single-Use Biomanufacturing Strategy
    Important Considerations For Implementing A Single-Use Biomanufacturing Strategy

    Recent trends in biomanufacturing technology and the biopharmaceutical market are supporting the increased adoption of single-use (SU) manufacturing systems. On the demand-side, the biopharma industry is focusing on niche and rare diseases with smaller patient populations, resulting in the need for smaller, more agile biomanufacturing capacity. By Jodi M. Zobrist and Nicole W. O'Brien, Ph. D., Gallus Biopharmaceuticals, LLC

  • Comparing The Automated Pipetting To Volumetric Glassware And Air Displacement Pipettes

    Analytical sample preparation is used in many industries such as forensics, environmental chemistry, mining, beer and wine fermentation and many others. Concentrated samples are diluted and analyzed via High Performance Liquid Chromatography, Gas Chromatography, Atomic Absorption, and/or Inductively Coupled Plasma Spectroscopy to name a few. Traditionally these samples are prepared using volumetric glassware, syringes and/or pipettes.

  • Driving Productivity In Protein Purification
    Driving Productivity In Protein Purification

    Crucial to the successful operation of any research laboratory is the ability to efficiently generate purified proteins for further investigation and analysis. By Per Lidén (GE Healthcare Life Sciences), Svend Kjær (Cancer Research UK) and Mark Cooper (Abcam)

  • Determination Of kLa Values Of Single-Use Bioreactors
    Determination Of kLa Values Of Single-Use Bioreactors

    Because single use bioreactors offered by  manufacturers vary in parameters critical for oxygen transfer, they are often not comparable to each other and to conventional glass and stainless steel vessels.

  • Challenges And Solutions Of Scalable Cultivation For Anchorage Dependent Cells In Single-Use Bioreactor
    Challenges And Solutions Of Scalable Cultivation For Anchorage Dependent Cells In Single-Use Bioreactor

    Microcarrier (MC)-based suspension culture processes have been used to culture anchorage-dependent cells in bioreactors. However, scale-up of the process for high cell growth and productivity poses many challenges. By Brian Lee, Yas Hashimura, Daniel Giroux, Marcos Sousa, Joao Clemente, Manuel Carrondo, Siddharth Gupta, Michael McCaman, and Yong-Jae Kim

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DOWNSTREAM PROCESSING PRODUCTS

FlexCessory™ End-Ported Biocontainer Hanging Stand FlexCessory™ End-Ported Biocontainer Hanging Stand

Meissner has developed a line of accessories to complement our One-Touch® single-use systems portfolio called FlexCessories™. The products in this portfolio are designed to facilitate the secure deployment and streamlined implementation of single-use systems.

Protein Purification Protein Purification

The chemical diversity of PBL's synthetic ligand libraries allows application to almost any target protein and provides extremely robust adsorbents which may be used in harsh processing regimes and multiple process cycles, even with crude process streams. PBL's affinity technology may be used in a variety of different ways including the capture of targeted proteins directly from biological source material, the highly selective separation of target protein from other components, or the removal of specific contaminants to provide increased yields, higher purities and reduced cost of goods.

FunctionMAX™ TiterEnhancer, AGT™ Additive FunctionMAX™ TiterEnhancer, AGT™ Additive

FunctionMAX™ TiterEnhancer uses a new technology to combine key nutrients in a highly concentrated, functional additive that is designed to reinforce existing feeds and amplify the productivity of standard high cell density fed-batch platforms. 

MPC Ceramic Hydroxyfluoroapatite Chromatography Media MPC Ceramic Hydroxyfluoroapatite Chromatography Media

MPC media, a composite of hydroxyapatite and fluoroapatite (Ca10(PO4)6(OH)1.5(F)0.5), is a complementary addition to our line of ceramic apatite mixed-mode chromatography media.

ÄKTA avant Chromatography System ÄKTA avant Chromatography System

ÄKTA avant is a preparative chromatography system designed for fast and secure development of scalable methods and processes.

Single-Use Sensors: SmartSensors Single-Use Sensors: SmartSensors

Finesse has designed an innovative range of single-use sensors to measure the four fundamental process parameters: pH, dissolved oxygen, temperature, and headspace pressure. The sensor sheaths are sealed into an insertion port and sterilized in place, so that process sterility is guaranteed.

Beckman Coulter Benchtop Centrifuge: Optima™ MAX Series Beckman Coulter Benchtop Centrifuge: Optima™ MAX Series

Elevating your laboratory’s potential starts with the optimal tabletop ultracentrifuge. And the Optima MAX Series is the absolute top of the line. Reaching up to 150,000 rpm and over 1,000,000 x g, Optima MAX instruments set the standard in tabletop speed.

MabSelect SuRe™ LX MabSelect SuRe™ LX

MabSelect SuRe LX is an alkali-stabilized, protein A-derived affinity medium with a binding capacity for monoclonal antibodies (MAbs) exceeding that of MabSelect SuRe at longer residence times.

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DOWNSTREAM PROCESSING MULTIMEDIA

Optima X Series Ultracentrifuge: Energy Efficient Technology, Real-Time Data Tracker

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Large Scale Automated Depth Filtration Video

The Zeta Plus Encapsulated System product portfolio for single-use depth filtration has been expanded to include the Model# 16EZC Multi-Round Holder.

GE Healthcare At AAPS: FTA DMPK Cards

Jim Robbins and Julie Hilton Demonstrate GE Healthcare's Whatman Indicating FTA DMPK cards.

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DOWNSTREAM PROCESSING INDUSTRY NEWS

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