DOWNSTREAM PROCESSING FEATURED ARTICLES

Superbugs May Have A Soft Spot, After All
Superbugs May Have A Soft Spot, After All

The overuse of antibiotics has created strains of bacteria resistant to medication, making the diseases they cause difficult to treat, or even deadly.

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DOWNSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

  • Rapid Development Of A Biosimilar Production Process Shows Dramatic Time Savings
    Rapid Development Of A Biosimilar Production Process Shows Dramatic Time Savings

    This application note describes the rapid development of a production process for a biosimilar molecule expressed in E. coli. Screening of modern chromatography media for downstream purification was done either with small packed columns and an ÄKTA avant system or with PreDictor plates (96-well pre-filled filter plates).

  • Scalable Expansion Of Human Pluripotent Stem Cells
    Scalable Expansion Of Human Pluripotent Stem Cells

    The routine application of human pluripotent stem cells and their derivatives in regenerative medicine and innovative drug discovery will require the constant supply of high cell numbers in consistent, high quality. By Ruth Olmer, Christina Kropp, Claudia Huether-Franken, Christiane Schlottbom, and Robert Zweigerdt

  • Global Biochemical Profiling For Bioprocess Optimization
    Global Biochemical Profiling For Bioprocess Optimization

    It is widely understood that the production phase of bioprocessing can have a significant impact on the overall profitability of the biopharmaceutical.

  • Cultivation Of CHO Suspension Cells And SEAP Expression In The Wave-Mixed Single-Use Finesse SmartRocker Bioreactor
    Cultivation Of CHO Suspension Cells And SEAP Expression In The Wave-Mixed Single-Use Finesse SmartRocker Bioreactor

    This application note describes the cultivation of CHO suspension cells in the wave-mixed single-use Finesse SmartRocker bioreactor with a maximum working volume of 5 L. Using a chemically defined minimal medium, it was possible to produce up to 16.4∙106 cells∙mL-1. SEAP expression was induced by medium exchange and a temperature shift. Maximum SEAP activity of up 33.1 U∙mL-1 was achieved. The results are comparable to cultivations in other wave-mixed bioreactor types. By Nadezda Perepelitsa, Stephan C. Kaiser and Dieter Eibl

  • The Use Of Dynamic Control In Periodic Counter-Current Chromatography
    The Use Of Dynamic Control In Periodic Counter-Current Chromatography

    The ÄKTA™ pcc 75 chromatography system can be used for purification of target proteins in continuous downstream processes using periodic counter-current chromatography (PCC). PCC enables greater utilization of the chromatography medium (resin) capacity, allowing sample loading to much higher levels compared with what is possible in traditional batch chromatography.

  • Rapid Chemically-Defined Feed Media Development to Improve Simulated Cell Culture Processes
    Rapid Chemically-Defined Feed Media Development to Improve Simulated Cell Culture Processes

    Implementing an optimized feed medium may be the most effective alternative for modifications to the growth medium in an existing process.

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DOWNSTREAM PROCESSING PRODUCTS

Pipette Tips Pipette Tips

The SoftGrip pipette and Hamiton AdvanTip Precision Pipette Tips create a liquid handling system designed for optimal performance. Ensure you are getting the Hamilton accuracy and precision advantage by using only Hamilton AdvanTip Precision Pipette Tips.

Allegra® X-30 Series Allegra® X-30 Series
The Allegra X-30 Series Benchtop Centrifuges were designed with your needs in mind providing you with excellent performance and easy operation in a compact design that saves you valuable time and laboratory space.
Protein Purification Protein Purification

The chemical diversity of PBL's synthetic ligand libraries allows application to almost any target protein and provides extremely robust adsorbents which may be used in harsh processing regimes and multiple process cycles, even with crude process streams. PBL's affinity technology may be used in a variety of different ways including the capture of targeted proteins directly from biological source material, the highly selective separation of target protein from other components, or the removal of specific contaminants to provide increased yields, higher purities and reduced cost of goods.

LifeASSURE™ PSA Series Sterilizing Grade Nylon Membrane Filter LifeASSURE™ PSA Series Sterilizing Grade Nylon Membrane Filter

Encompassing two leading-edge processes, multi-zone microporous membrane construction and Advanced Pleating Technolog (APT) design, LifeASSURE™ PSA Series filters offer robust 0.20 and 0.10 micron absolute-rated filtration and exceptionally long service life.

Biopharmaceutical Process Development Biopharmaceutical Process Development

The efficient expression of a therapeutic protein in microbial or mammalian cells is often a bottleneck in the production of biopharmaceuticals.

Containment: Bag In Bag Out Containment: Bag In Bag Out

The DoverPac® Bag In/Bag Out (BIBO) containment system is a family of contained transfer designs for multiple processes. The primary components for this validated operation consist of multiple groove canisters, docking interface hardware, and softgoods in either continuous liner form or discreet liners.

Single Use Biopharmaceutical Powder Handling Equipment Single Use Biopharmaceutical Powder Handling Equipment

ILC Dover brings a unique history and skill set to the biopharmaceutical industry, particularly single use biopharmaceutical powder handling and containment equipment.

Beckman Coulter Centrifuges: Microfuge® Series Microcentrifuges Beckman Coulter Centrifuges: Microfuge® Series Microcentrifuges

Get fast micro-centrifugation in an easy-to-use, compact design. The Beckman Coulter Microfuge® Series offers the performance and reliability you demand—and have come to expect.  Intuitive user interface display, increased speed and capacity, safety, and multiple rotor options are just a few of the many features the Microfuge® offers.

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DOWNSTREAM PROCESSING MULTIMEDIA

Optima X Series Ultracentrifuge: Energy Efficient Technology, Real-Time Data Tracker

Beckman Coulter's Randall Lockner, marketing manager for centrifugation, explains the highlights of the floor model ultracentrifuge, the Optima X Series.

Large Scale Automated Depth Filtration Video

The Zeta Plus Encapsulated System product portfolio for single-use depth filtration has been expanded to include the Model# 16EZC Multi-Round Holder.

GE Healthcare At AAPS: FTA DMPK Cards

Jim Robbins and Julie Hilton Demonstrate GE Healthcare's Whatman Indicating FTA DMPK cards.

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DOWNSTREAM PROCESSING INDUSTRY NEWS

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