Insights On Downstream Manufacturing

  1. How Innovative Valve Design Drives Efficiency And Product Protection 8/20/2026

    Thoughtful design at the bioreactor and ATF interface can reduce shear, simplify fluid paths, and conserve space. See how rethinking an overlooked valve assembly helped improve process efficiency.

  2. Improving AAV Manufacturing: Advancements In Full Capsid Enrichment 8/19/2026

    As AAV manufacturing matures, integrated optimization of capture, buffer chemistry, load conditioning, and AEX polishing enables scalable full capsid enrichment, improving product quality and manufacturability.

  3. Chromatography Equipment Maintenance In An Era Of Acceleration 8/19/2026

    As chromatography systems become more sophisticated, maintenance directly influences uptime. Learn why coordinated maintenance strategies are essential for supporting complex analytical work.

  4. Lyophilization Process Development For Antibody Drug Conjugates 8/18/2026

    See how scientific process development and QbD principles improve freeze-drying performance, strengthen product stability, and support biologics scale-up.

  5. Why Upstream-Downstream Alignment Determines Success In Complex Biologics 8/18/2026

    Aligning early upstream choices, downstream purification, and analytical testing prevents scale-up delays, reduces process variability, and protects timelines for complex biologics.

  6. SEC HPLC Columns With Ultra Inert Technology 8/18/2026

    See how reducing secondary interactions in size exclusion chromatography gives scientists greater freedom to optimize conditions around their samples, helping simplify method development.

  7. Unified Lab Software For Modern QC Workflows 8/17/2026

    Manage increasingly complex chromatography workflows with a scalable data system that supports secure data management, instrument control, analysis, reporting, and high-resolution characterization.

  8. How Downstream Processing Decisions Impact EV Yield, CQAs, & Cost Of Goods 8/14/2026

    Learn how downstream processing decisions in EV and exosome manufacturing affect product yields, quality attributes, and overall cost of goods.

  9. Expanding Subcutaneous Design Brick By Brick 8/14/2026

    Biologics are growing more complex. But what if the syringe itself could unlock new possibilities? Discover the technology “bricks” quietly reshaping subcutaneous drug delivery.

  10. Fixing AAV Recovery With Siren Biotechnology's Nathalie Clément, Ph.D. 8/11/2026

    In this episode of “Better Biopharma,” host Tyler Menichiello is joined by Nathalie Clément, Ph.D., Siren Biotechnology’s SVP of vector development. The two discuss the historical challenges of purifying AAV vectors and the developments that have allowed for greater product yields.