Industry Insights

31. Manual Whole-Cell Patch Clamp Assay For Screening NCE's Against Voltage Gated Ion-Channels 5/13/2025

    Ensure the cardiac safety of your drug candidates by leveraging manual whole-cell patch-clamping to assess their impact on hERG channel interactions and prevent potential QT prolongation risks.

32. Critical Thinking In Root Cause Investigations: Asking The Right Questions 7/27/2020

    As we write or review a root cause investigation, it is up to each of us to challenge the information we are given, and ensure it stands up to a critical analysis.

33. Renovating An Existing Biotech Plant To Accommodate A Higher-Titer Product 1/11/2018

    Today, a wide spectrum of plants are moving into their next generation of production of monoclonal antibodies (mAbs) and other therapeutic expressions. This new higher titer changes the way we look at both the process and the facility.

34. Automating Cell Therapy Systems For Better Results 2/23/2020

    Cell therapy treatments are often made at a small-scale, require days of manual preparation, and are usually produced for use in a clinical trial. What if it were possible to get results on a much broader scale?

35. Biopharma Cold Chain Logistics 101 4/9/2021

    Cold chain logistics can be complex and intricate. Maintaining the integrity of controlled-temperature products requires holistic consistency between design and development, manufacturing and packaging, qualification and validation, cold storage, transportation, and monitoring as the product moves from its point of origin to the end user.

36. Bacterial Endotoxin Testing, Part 1: Overview 7/16/2024

    All injectable drug products and implantable medical devices that come into contact with the bloodstream or spinal fluid are tested for endotoxins. This article provides an overview of bacterial endotoxin testing and the LAL method.

37. Reconsidering Impact: Single-Use Vs. Stainless-Steel Systems 12/2/2022

    Explore different pollution-contributing factors in biochemical manufacturing, spatial considerations when comparing disposable to traditional systems, and current environmental-based initiatives.

38. The Next Level: Why Move To A Bioreactor? 1/22/2020

    Moving beyond the incubator and shaker to bioreactors and fermentors enables ideal environments for cellular reproduction and product formation, increasing experimental yields and enhancing reproducibility.

39. Are Single-Use Technologies Always The Answer? 1/9/2024

    It is clear that single-use technologies (SUTs) have won the war over reusable stainless steel. However, beneath the surface, there is a web of considerations that challenge the belief that SUTs are unequivocally cost-effective. Let's look at cost considerations as well as risk considerations.

40. Uncovering Cell Culture Media's Part In Latest Biopharma Trends 7/19/2024

    Cell culture media are ubiquitous in just about every bioprocess system, and advanced modalities are putting specialty media in the spotlight.