Industry Insights

  1. Tips For Performing Preparative Chromatography And Protein Purification

    This articles provides some fundamental tips and tricks to preparative chromatography that will yield a pure sample preparation that will advance protein characterization studies.

  2. 6 Types Of Diseases Related To Endotoxins Of Gram-Negative Bacteria

    Almost any environment is appropriate for the development of Gram-negative bacteria, given that contamination with these bacteria is very common.

  3. Making Novel Therapies A Reality Part 1

    Cell therapy, gene therapy, and RNA-based therapies. Right now, those are the classes of therapies we’re considering novel. If you look at it historically, ten years ago, recombinant proteins and monoclonal antibodies would have been novel therapies, but now they’ve become very much standardized. So now that bar has moved a little bit, and the novel therapies are really cell and gene therapies, and to a certain extent the RNA therapies.

  4. Site Selection And Development Utilizing A Colored Stop/Go Rated Matrix

    Clients usually have a preconceived idea of where a new process will go and how much space is available, but preconceived notions may lead to a point where project needs haven’t been met.

  5. Incorporate Data Integrity Into Your Pharma Quality Management System

    A viable QMS cannot be based upon anything except data and records that are attributable, legible, contemporaneous, original, accurate, complete and easily retrievable. 

  6. The Relationship Between The Chemical Nature Of Bacterial Endotoxins And Their Toxicity And Immunogenicity

    The diseases related to Gram-negative bacteria affect humans and animals and, in many cases, are difficult to treat, which is why is important to have effective and bacteria-specific antibiotics.

  7. Streamlined Supply Chain Solutions Boost Efficiency

    When customers consolidate their supply chain and use one vendor from drug substance through drug product, it can transform the entire drug development process into a more efficient system.

  8. How The Built Environment Influences Engineering Education

    While the mode of instruction changes to enhance student learning, the facility in which students learn should also evolve.

  9. Development Of A Two-Column Manufacturing Process For Adenovirus

    Large-scale downstream processing of viruses for clinical applications poses challenges different from those for many other biotherapeutics. Adenovirus vectors are effective tools for the transfer of genetic material into mammalian cells. They offer several advantages, including the capacity to accommodate up to 37 kb of foreign genetic material, very high infection efficiency, ability to infect a wide variety of both dividing and nondividing cell types, lack of integration into the host chromosome, and availability of production systems capable of generating high virus titers.

  10. Getting Ready For Phase 1 In Pharmaceutical Development

    At the early stages of product development, pharmaceutical development scientists are under increasing time pressure to select the right molecule form, the right formulation and the right final dose form.