Cytiva product datasheets, catalogs, app notes
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Capacity And Performance Of MabSelectâ„¢ PrismA Protein A Chromatography Resin
10/2/2018
This application note demonstrates the binding capacity of MabSelect PrismA in comparison with its predecessor products for both polyclonal and monoclonal antibodies.
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Downstream Process Development For Efficient Purification Of Adenovirus
9/10/2018
Here, we describe the development of two effective downstream processes for purification of adenovirus from cell culture harvest.
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Optimization Of Midstream Cell Lysis And Virus Filtration Steps In An Adenovirus Purification Process
9/10/2018
Here we describe screening of detergents for release of adenovirus from HEK293 host cells to replace the traditionally used detergent Triton™.
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Process Economy Of Using Cytodex Gamma Microcarriers
8/3/2018
Microcarriers are commonly used in bioreactor cultures to provide a large growth surface for anchorage-dependent cells, and are typically provided either untreated or gamma-irradiated and ready for use.
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Accelerated Manufacturing Of Subunit Vaccines For A Rapid Pandemic Response
8/3/2018
This application note describes a process for rapid production of recombinant anthrax protective antigen (rPA) in short process time for the manufacture of an anthrax subunit vaccine.
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Efficient Purification Of The Pertussis Antigens Toxin, Filamentous Haemagglutinin, And Pertactin In Chromatography Workflows
2/21/2018
Read how this method resulted in higher purity and yield than what can be expected from a purification process based on salt precipitations and sucrose gradient centrifugation.
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Automated In-Line Buffer Prep Saves Time And Facility Footprint
2/1/2018
Buffer preparation is both time- and space-consuming and become a challenge in biomanufacturing. This application note describes a lean approach to buffer preparation by implementing in-line conditioning.
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Continuous Chromatography In Downstream Processing Of A mAb
2/1/2018
In this study, periodic counter current (PCC) chromatography and straight-through processing (STP) technologies were evaluated in a continuous three-step monoclonal antibody (mAb) purification process.
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Seed Culture Expansion Process: Reduce Time And Maximize Utilization
12/15/2016
This application note describes how perfusion cell culturing can be used to reduce processing time, simplify operations, and maximize equipment utilization in seed culture expansion processes. For creation of high-density cell banks, Chinese hamster ovary (CHO) cells were expanded using a bioreactor system operated in perfusion mode.
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Resolving Bottlenecks of Recombinant Antibody Fragments
6/6/2016
Antibodies and their derivatives are increasingly important and essential tools for biological research. Techniques to screen and characterize large numbers of antibodies and provide confident selection of the best candidates for development are therefore essential. Details described in this method will provide rapid screening in combination with data-rich selection of fragments with high affinity and the desired kinetic behavior.