Multi-Parallel Microscale Bioreactor System Unlocks Bottlenecks In Bioprocess Development

Implementation of high throughput automated systems is recognised as a valuable approach in the field of bioprocess development.

An efficient multi-parallel microscale bioreactor system can unlock development bottlenecks in a variety of bioprocess applications, such as cell line screening, media development, feed and process optimisation, QbD and DoE studies.

Aims

• Illustrate the capability of the ambr system with CHO cell cultures
• Assess the degree of reproducibility for replicate ambr cultures
• Investigate the resolution in CHO cell culture response for a variety of experimental conditions (signal to noise ratio)
• Demonstrate Process Control Performance in the ambr system
  • Steady State Control for standard culture operation
  • Dynamic Control for parameter shift applications