BioPAT® Spectro: Enabling Transfer Of Raman Calibration Models Across Bioreactor Scales

Over the past twenty years, the biopharmaceutical industry has increasingly embraced the use of Process Analytical Technology (PAT) as a cornerstone of Quality by Design (QbD) in the manufacturing of biological drugs. Among the various PAT tools, Raman spectroscopy has emerged as a powerful technique due to its ability to provide non-invasive, real-time measurements of critical process parameters and quality attributes. This capability has significantly transformed how bioprocesses are monitored and controlled, offering enhanced precision and responsiveness. Despite these advantages, a major hurdle remains: ensuring that calibration models developed on small-scale systems can be reliably transferred to larger, commercial-scale bioreactors. Sartorius has addressed this challenge through its BioPAT® Spectro system, which features an identical flow cell design across both small- and large-scale bioreactors. This design consistency supports seamless model transfer. 

Explore how this innovation not only streamlines the scale-up process but also reinforces the reliability and scalability of Raman-based PAT in biopharmaceutical manufacturing.