The loss of product as a result of bag failure isn’t just an annoyance; it’s an expense, and a costly one at that. However, Chuck Hart, director of manufacturing at Prolong Pharmaceuticals, says with proper fitting and handling, these concerns can be mitigated.
It can be said that 2014 was the year of genomics. The industry saw several new startups in the area, and Google's venture into the genomics market made a big splash. However, in 2015 the industry is expected to look beyond genes and focus on a dual approach to drug development leveraging data from both the genes and the tissue, particularly in oncology.
When Mary Lavin began her career at Sartorius in 1988, when the company set up operations on Long Island, it had combined U.S. sales of $20 million and 40 employees in the states. A lot has changed since then. The company now has over 800 employees in North America and expects 2015 sales to exceed $350 million. But the company is not done growing. On June 2nd, Sartorius had a grand opening ceremony for its new Application Center in Bohemia, NY, which will help the company to continue to meet the needs of its growing customer base.
The Standardized Extractables Testing Protocol For Single-Use Systems In Biomanufacturing written by BPOG members last year establishes a foundation from which to create a standardized approach to extractables testing. However, since its release, there have been some questions and discussions about how to effectively implement the protocol.
The pipeline of biopharmaceutical drugs is rich and becoming increasingly diverse. Many new biologic modalities are being developed as established therapeutic classes move through their lifecycle. Wide arrays of different types of molecules are expected to coexist within product portfolios and manufacturing networks. It is clear that this will have a significant impact on manufacturing facilities. Strategies need to be developed to prepare facilities for these challenges.
A significant proportion of academic and drug discovery research is devoted towards the elucidation of second messenger signaling cascades resulting from interactions between G-protein coupled receptors (GPCR) and their ligands. By Paul Held Ph. D. and Peter Banks, Ph. D., BioTek Instruments, Inc. and Paul Tewson, Anne Marie Quinn and Thom Hughes, Montana Molecular
We describe the use of a non-radioactive, bioluminescent Antibody-Dependent Cell- Mediated Cytotoxicity (ADCC) assay. The protocol is a simple sequential addition of reagents and cells that can be readily automated with a simple, inexpensive pipetting station.
AKT is a serine/threonine protein kinase that plays a key role in cellular processes. AKT has become a popular target for drug discovery campaigns, due to the fact that AKT inhibitors may help to treat a number of cancers.
With Cell Culture Flask Adapters, the culture can be centrifuged directly in the flask. Data illustrates that cell yield, cell viability, and endpoint analysis results are comparable when cell cultures are processed traditionally or centrifuged directly in the flask using Cell Culture Flask Adapters.
Human serum albumin (HSA) has a vast array of applications within the BioPharmaceutical industry including; plasma expansion, formulation excipient, drug delivery, wound healing as well as extending the half-life of a protein drug as a fusion partner.
America's biopharmaceutical companies are using biological processes to develop 907 medicines and vaccines targeting more than 100 diseases, according to a new report released today by the Pharmaceutical Research and Manufacturers of America (PhRMA).
Baxter International Inc. has begun dosing patients with malignant solid tumors in a Phase I clinical trial of a monoclonal antibody, representing the company’s efforts to extend its oncology portfolio with advanced biological research and development.
Sirnaomics, Inc. (www.sirnaomics.com) announced today that the company has been awarded another NIH SBIR (Small Business Innovation Research) grant for developing its small interfering RNA (siRNA) therapeutic product STP705 to improve skin wound healing with minimized scar formation.