UPSTREAM PROCESSING FEATURED ARTICLES

How Can You Mitigate The Risks Of Single-Use Bags?
How Can You Mitigate The Risks Of Single-Use Bags?

The loss of product as a result of bag failure isn’t just an annoyance; it’s an expense, and a costly one at that. However, Chuck Hart, director of manufacturing at Prolong Pharmaceuticals, says with proper fitting and handling, these concerns can be mitigated.

  • Genomics & Tissue Phenomics: Taking A Dual Approach To Drug Development
    Genomics & Tissue Phenomics: Taking A Dual Approach To Drug Development

    It can be said that 2014 was the year of genomics. The industry saw several new startups in the area, and Google's venture into the genomics market made a big splash. However, in 2015 the industry is expected to look beyond genes and focus on a dual approach to drug development leveraging data from both the genes and the tissue, particularly in oncology.

  • Standardized Extractables Testing Advances Single Use Adoption
    Standardized Extractables Testing Advances Single Use Adoption

    The Standardized Extractables Testing Protocol For Single-Use Systems In Biomanufacturing written by BPOG members last year establishes a foundation from which to create a standardized approach to extractables testing. However, since its release, there have been some questions and discussions about how to effectively implement the protocol.

  • Single-Use Standardization: Is It Holding Back The Biopharma Industry?
    Single-Use Standardization: Is It Holding Back The Biopharma Industry?

    The data from BioPlan Associates’ 12th Annual Report and Survey of Biopharmaceutical Manufacturing Capacity and Production speaks to the industry’s ongoing desires for standardization in single-use devices. As usage of these disposable devices increases, the gap between the importance of standardization and end-users’ satisfaction with their supplier’s standardization efforts has steadily been worsening. 

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UPSTREAM PROCESSING WHITE PAPERS & CASE STUDIES

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UPSTREAM PROCESSING PRODUCTS

Single-Use, Flexible Stirred-Tank Bioreactor System: Xcellerex XDR-10 Single-Use, Flexible Stirred-Tank Bioreactor System: Xcellerex XDR-10

This XDR single-use bioreactor is sized for the benchtop, yet allows smooth scale-up to full production.

One Film For Your Entire Upstream Production: CX5-14 One Film For Your Entire Upstream Production: CX5-14

Thermo Scientific CX5-14 film is engineered to meet the most demanding requirements of your bioproduction processes.

Single-use Clarification Systems: Sartoclear Dynamics® Single-use Clarification Systems: Sartoclear Dynamics®

Sartoclear Dynamics® is a new single-use technology for harvesting animal cell cultures with high cell densities. Consistent results, ease of use, enormous speed and flexible scalability are the key characteristics of this technology.

Mix-Mode Chromatography Resin Mix-Mode Chromatography Resin

Mixed-mode chromatography resin is a top tier selection for the manipulation, purification and handling of molecules; providing an unmatched level of separation properties and resolution. The combination of cation exchange resin and metal affinity resin properties, allows multimodal chromatography to provide an access route for biomolecules to separate and the use of alternative chromatographic methods make these biomolecules seem homogenous.

HyPerforma™ Single-Use Fermentor (S.U.F.) HyPerforma™ Single-Use Fermentor (S.U.F.)

The S.U.F. is engineered for optimal oxygen mass transfer, mixing, and temperature control, and performs comparably to traditional stainless steel systems. Using traditional, fundamental engineering principles, scale-up and process development work is streamlined – offering you cost savings and efficiency. 
 

CELLine™  Bioreactors Advanced Cell Cultivation Devices CELLine™ Bioreactors Advanced Cell Cultivation Devices

In an effort to push science forward, WHEATON is manufacturing  a new line of membrane driven flasks for high density cell culture. The flasks are designed to enhance small scale bio-production for antibody and protein generation.

Macro-Prep Methyl HIC Media Macro-Prep Methyl HIC Media

Macro-Prep hydrophobic interaction chromatography (HIC) media are methacrylate-based, 50 µm beads used for protein, polypeptide, enzyme, and nucleic acid purification.

Macro-Prep t-Butyl HIC Media Macro-Prep t-Butyl HIC Media

Macro-Prep hydrophobic interaction chromatography (HIC) media are methacrylate-based, 50 µm beads used for protein, polypeptide, enzyme, and nucleic acid purification.

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UPSTREAM PROCESSING MULTIMEDIA

Viral Defense From A New Perspective For MVM Contamination Viral Defense From A New Perspective For MVM Contamination

MilliporeSigma has identified a gene target (Slc35A1) that, upon elimination of expression by gene editing, results in a CHO cell line that is resistant to infection by Minute Virus of Mice (MVM). This technology is called Centinel™ Intelligent Virus Defense and it goes beyond viral insurance. It’s an integral component of a sophisticated virus mitigation strategy for preventing, detecting and removing viruses.

Applikon BioSenz Glucose Analyzer Gives Real-Time Glucose Level Measurements In Bioreactors

Lori Clapper talks with Wesley Marner, manager, small-scale technologies, at Applikon.  Wesley expressed how companies desire to get more data out of their bioprocesses, and accomplish that in a more automated fashion.  With that, you will have a better real-time handle on what your process is doing, and better control of the overall performance of your process. He also discussed how Applikon’s BioSenz Glucose Analyzer helps you do just that.

Easily Switch Between Washing And Filtration With An Interchangeable Microplate Washer

The Hydroflex microplate washer is a modular and upgradeable platform is ideal for a wide range of cell-, enzyme- and DNA-based applications in academia, biotech, pharma and clinical diagnostics, reflecting over 30 years of Tecan expertise in advanced liquid handling.

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UPSTREAM PROCESSING INDUSTRY NEWS

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