Insights On Upstream Manufacturing

  1. Cell Culture Media Filtration: Evaluating Cell Culture Performance 10/23/2025

    Cell culture performance remained consistent across PES and PVDF filters, even under worst-case filtration conditions. Discover a practical framework for evaluating membrane impact on CHO cell growth.

  2. Enhancing Non-Viral CAR T Manufacturing With Electroporation And Microbubble T Cell Isolation 10/22/2025

    Unlock superior non-viral CAR T manufacturing outcomes by combining gentle microbubble T cell isolation with advanced electroporation. See how this approach boosts cell viability and transfection efficiency.

  3. Game-Changing CLD Platforms: Strategies, Technologies, Workflows 10/21/2025

    Selecting the right cell line platform is complex. Learn how flexible strategies, integrated technologies, and expert workflows enable high productivity, rapid timelines, and a de-risked path to clinical success.

  4. Developing Antibodies To Block Neuroinflammation With MindImmune's Stevin Zorn, Ph.D. 10/20/2025

    In this episode of "Better Biopharma," host Tyler Menichiello is joined by MindImmune's president and CEO, Stevin Zorn, Ph.D. They discuss the development of the company's lead candidate, MITI-101, a monoclonal antibody designed to prevent peripheral immune cells from entering the brain and driving neuroinflammation linked to Alzheimer's disease.

  5. Development Of An Off-The-Shelf γδ T-Cell Platform 10/20/2025

    Learn how γδ T cells are being engineered into scalable, off-the-shelf therapies with enhanced safety and potency, as well as discover strategies to overcome immunological barriers.

  6. Predicting The Performance Of Perfusion Media In A Continuous Bioreactor 10/17/2025

    Small-scale perfusion-mimic models can effectively predict media performance in continuous bioreactors to help optimize cell density, productivity, and scalability for CHO cell lines.

  7. Simplify Process Scale-Up With An Innovative Single-Use Bioreactor 10/15/2025

    Consistent cell growth and protein yields from 5 L to 5,000 L show how a unified bioreactor design can simplify scale-up, reduce risk, and accelerate upstream process development in bioproduction.

  8. 2L Face Ported Bioprocess Bags: Closed, Sterile Cell Harvest, And Separation 10/15/2025

    Explore single-use 2L face ported bags designed for efficient cell harvest and separation that offer robust film technology, full traceability, and seamless integration with Sorvall BIOS 16 systems.

  9. Break The Cell Therapy Manufacturing Bottleneck With Day-0 Transduction, Day-3 Harvest 10/14/2025

    Discover the potential of T1 cell-derived nanoparticles (CDNPs) to accelerate T-cell activation. See how CDNPs’ unique mechanism of mimicking physiological immune stimulation positions them for broad use.

  10. High-Throughput Screening For High-Performance Cell Culture Media Development 10/14/2025

    Learn about a high-throughput screening method that successfully optimized cell culture media, leading to a greater than 3-fold improvement in viral genome titer for AAV2 production.