Insights On Upstream Manufacturing

  1. Streamlining pDNA: Capacity, Complexity, And Cutting-Edge Solutions 11/20/2025

    Learn how flexible facility design and process innovation are accelerating pDNA manufacturing, as well as key strategies to avoid scale-up pitfalls and meet growing therapeutic demand.

  2. Accelerating A Complex Molecule From CLD To cGMP In 12 Months 11/19/2025

    Learn how to mitigate technical risk, implement parallel process development, and design custom purification strategies for highly sensitive novel modalities to accelerate to cGMP material.

  3. Inside Bioprocessing: Next Generation CHO Media And Feeds 11/19/2025

    Discussing the potential of next generation cell culture media and feed systems to enhance monoclonal antibody production.

  4. The Proven, Practical Gateway To Upstream Process Intensification 11/18/2025

    N-1 perfusion enables higher inoculum densities, faster production, and reduced costs without altering fed-batch processes. Explore a practical path to intensification for biologics manufacturers.

  5. Enabling MSC Harvest, Wash, And Concentration 11/17/2025

    A study demonstrates how a low-shear, closed-system centrifuge achieved over 90% MSC recovery and minimized viability loss, supporting scalable cell therapy manufacturing.

  6. Advancing Biologics Development With Next-Gen Cell Line Development 11/17/2025

    Next-gen CLD utilizes transposase-mediated integration for speed and stability and employs an engineered cell line to enhance ADCC and a high-throughput assay for early glycosylation control.

  7. Rethinking Peptones As First-Line Optimization Tools 11/14/2025

    Peptones enhance CHO cell growth, viability, and yield, offering a fast, low-risk way to improve bioprocess performance without major process changes.

  8. Multispecific Antibodies: Key Challenges And Solutions To Enable A New Frontier In Cancer Treatment 11/14/2025

    Multispecific antibodies are a newer class of cancer therapeutics addressing tumor complexity. Learn about the design, manufacturing, and regulatory challenges and integrated solutions accelerating their development.

  9. Simplify Your Cell Culture Processes 11/13/2025

    Discover bioreactors that combine fast setup, robust design, and scalable performance to streamline cell culture workflows, which help you move from uncertainty to control, no matter your molecule.

  10. Understanding Adeno-Associated Virus Vector Impurities 11/13/2025

    AAV vectors hold promise for gene therapy, but removing product-related impurities remains a challenge. Learn how cell line development and process optimization are advancing rAAV production.