Inside The Technology Advancing CHO Therapeutic Protein Expression

For more than 30 years, Lonza's GS Gene Expression System® has supported protein expression and cell line development, helping bring more than 100 biologics to market. In this video, Dr. Peter O'Callaghan, Senior Director and Head of Expression System Sciences, Licensing, answers key questions about the platform and the technologies behind its performance.

The discussion explores how the integrated system combines a CHO host cell line, next-generation expression vectors, and Lonza's hyperactive GS piggyBac® transposase technology to support high titers, expression stability, product quality, and efficient development timelines. Dr. O'Callaghan also highlights the latest vector platform and the genetic elements designed to enable robust, stable production.

The video then surveys the broader toolbox available through a research license — digital tools that simplify vector design, technical support, the GS Xceed® cell line for afucosylated antibody production, and GS Discovery for transient gene expression.

Watch the full video to learn how the GS Gene Expression System® streamlines protein expression and cell line development, from vector design through scalable production.