Insights On Downstream Manufacturing

1. Enhancing Viral Vector Sterile Filtration: Process Efficiency And GMP Alignment 11/4/2025

   Explore filtration strategies that improve viral vector yield and quality, with insights on AAV and lentivirus workflows, plus practical guidance for implementing PUPSIT in line with requirements.

2. Use Cation Exchange Chromatography For High Yields In Vaccine Production 11/4/2025

   Learn how to achieve high yields in vaccine production by using Cation Exchange Chromatography for purifying SARS-CoV-2 spike proteins. This method provides high purity and minimizes protein aggregates.

3. Leveraging 3 Distinct Resins To Provide Effective Impurity Removal For mAbs And Novel Antibody Derivatives 11/3/2025

   Due to the complexity of bispecifics, Fc-fusion proteins, and Fab fragments, their manufacturing poses added purification challenges and requires a robust toolkit of purification techniques.

4. THESYS ACS ERGO Column Packing And Unpacking 10/31/2025

   The time between batches for oligonucleotide synthesis has long been a bottleneck, consuming valuable lab time with complex, multi-step column maintenance. A new column design can simplify this process.

5. Overcoming Scale-Up Challenges In Viral Vector TFF 10/29/2025

   Discover how a tailored TFF solution delivers a scalable, high-yield process that integrates smoothly with existing infrastructure and maintains regulatory compliance.

6. Implementing A Versatile Mixing System To Drive Down Costs 10/29/2025

   Learn how a CDMO reduced capital expenses and operational complexity by adopting an all-in-one mixing solution that supports every stage of production and a wide range of volumes.

7. Optimize DNA Clearance In High-Salt, GMP-Grade Purification Processes 10/28/2025

   Explore how salt-active endonucleases overcome DNA clearance challenges in viral vector purification by digesting down to 3–5 nucleotides and performing reliably in high-salt conditions.

8. Strategies For Enhancing Bioprocessing Productivity 10/27/2025

   New complex therapeutics demand a shift from traditional bioprocessing. Learn how innovative strategies and resin technologies can help you manage costs and efficiently scale production.

9. Freezing Bottles – 5 Critical Considerations 10/27/2025

   Learn five critical considerations for freezing bottles, including uniform rate control, container integrity, and selecting the right freezing technology to maintain product stability and process efficiency.

10. Supporting Complex Manufacturing For Liquid And Lyophilized Drug Products 10/24/2025

    Aseptic fill and finish operations gain efficiency and precision with modular isolator technology, inline weight checks, and lyophilization, which are ideal for mRNA-LNPs and other sensitive modalities.