Expert Insights On Upstream Bioprocessing

1. Dynamic Flux Analysis Offers Faster Metabolic Modeling Than DOE 2/27/2026

   By continuously analyzing spent media, researchers can estimate reaction rates at regular time points, providing a granular view of cell metabolism.

2. The Hidden Engineering Behind Successful Upstream Bioprocessing 2/25/2026

   In upstream biopharmaceutical production, manufacturing is inseparable from biology, engineering, contamination control, and quality science.

3. Using Carbon Nanotubes To Pinpoint Optimal Harvest Time in Bioprocessing 2/18/2026

   Cell-free expression systems confound the moment of peak expression. These nanosensors signal through crude lysate for process optimization and endpoint monitoring.

4. This Industrial Fungus Has Protein Expression Promise For Pharma 2/12/2026

   Trichoderma reesei is well characterized for industrial uses. A Finnish research group is exploring it for pharmaceutical protein expression.

5. High Specific Productivity For Leaner Sustainable Bioprocessing 1/30/2026

   Improving specific productivity moves the goal beyond pumping out higher titers, but it demands a deeper understanding of cellular biology and protein expression.

6. Why Use Total Organic Carbon Analysis For Cleaning Validation? 1/21/2026

   Total organic carbon analysis is probably the most “fit for use” analytical method to validate cleaning processes, particularly within a science- and risk-based approach.

7. Moving Leukopaks From GTP To GMP Is One Cell Therapy Trend To Watch In '26 1/9/2026

   Cell therapy stumbled in 2025. Solving the variability in starting material quality is critical to stabilizing manufacturing in 2026.

8. Ask The Pros — The Latest In Upstream HCP Mitigation 1/5/2026

   We asked leading experts how upstream interventions can reshape HCP control. Here’s what they shared. Answers have been edited for clarity.

9. Survey: SUS Insufficient For 40% Of Biopharma 12/30/2025

   New data from BioPlan Associates suggests single-use systems adoption may be plateauing with single-digit growth rates.

10. TFF Offers Ideal Anaerobic, GMP Conditions For LBP Concentration 12/8/2025

    When configured correctly, TFF provides the gentle processing environment and oxygen protection required for strict anaerobes.