Expert Insights On Upstream Bioprocessing

1. Analyzing CAR-T Surface Proteins With Immunoprecipitation Coupled With Mass Spectrometry 10/24/2025

   Among other benefits, the approach can help compare CAR constructs, evaluate the effects of manufacturing processes, and monitor changes in protein interactions.

2. How Sethera Harnesses A Promiscuous Enzyme To Make Recombinant Peptides 10/21/2025

   A class of enzymes previously believed to be specific and intolerant of change might actually have broad applicability.

3. CRISPR And iPSC Disease Modeling And Drug Screening 10/14/2025

   iPSCs combined with the CRISPR-Cas9 gene editing system can construct or repair mutations and establish highly accurate, controllable in vitro models.

4. Fermentation Of Live Biotherapeutic Products In cGMP Environments 10/8/2025

   We follow the journey from master cell bank to large-scale anaerobic fermentation, highlighting the unique needs for working with oxygen-sensitive, strictly anaerobic therapeutic microbes in a cGMP setting. 

5. Survey: 30% Of Biopharmas Cite Cost, Productivity As Top Priorities 10/6/2025

   Both focus areas aim at the same outcome, stronger economics and sustainable competitiveness, according to BioPlan Associates' 22nd Annual Biomanufacturing Report.

6. CGT Success Starts With The First Mile 9/23/2025

   The so-called "last mile" in cell therapy gets a lot of attention. What about the first mile, the journey cells take between the donor and the manufacturing site?

7. Can CHO Bioreactors Be Used For Plant-Based Protein Production? 9/22/2025

   The moss Physcomitrium patens is especially good at producing glycoproteins. Established technology and prior knowledge are helping one company develop new therapies with it.

8. How To Grow CHO Cells Without Cysteine, Tyrosine Feeds 9/19/2025

   Researchers at Pfizer are developing a cell line that synthesizes these amino acids autonomously, which could reduce costs and increase stability.

9. Unpacking Pfizer's Advanced Process Control Platform For Upstream Ops 8/29/2025

   Pfizer's advanced process control platform gives modelers more dexterity compared to default controllers, thus speeding up process development.

10. Calculating The Right In-House/Outsource Mix For ADC Manufacturing 8/21/2025

    Antibody-drug conjugate innovators often question whether to outsource manufacturing activities or bring them in-house. Here are some key considerations.