Bioprocessing White Papers
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Development And Optimization Of Suspension-Adapted 293T Cell Line
3/21/2024
Learn how an adapted cell line can reduce costs and improve scalability in the production of lentiviral vectors for CGTs and examine its potential to produce GMP-grade lentiviral vectors.
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Advancing A LNP Formulation To Clinical And Commercial Manufacturing
3/21/2024
Lipid selection impacts the final LNP drug product and the LNP process. Review critical quality considerations for lipids and the process requirements for successful commercial-scale manufacturing.
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Manufacturing Challenges With High Concentration Biologics
3/18/2024
Explore key process operations, some of the challenges in manufacturing high-concentration biologics, and factors to consider for process optimization.
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A Mammalian Suspension Technology For Scalable rAAV Production
3/13/2024
Explore a HEK293 derived animal component-free suspension cell line as the foundation of an up to 2000-liters scalable and robust platform process that increases the speed of AAV manufacturing.
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Accelerating The Development And Production Of High-Quality Bispecific Antibodies
3/7/2024
bsAbs are revolutionizing medicine by targeting two disease mechanisms simultaneously. Learn how an innovative platform offers excellent pairing and significantly enhances productivity and quality.
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A Scalable Single-Use Two-Step pDNA Purification Process
3/6/2024
Evaluate the performance of a single-use two-step plasmid purification process, and see how it compares to the existing three-step purification method.
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Five Essentials For Accurate Oligonucleotide Chemistry
3/4/2024
Explore five key areas in oligonucleotide chemistry where improvements will have a huge influence on your synthesis quality.
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Response To FDA Black Box Warning
3/1/2024
The FDA has launched an investigation into the risk of T-cell malignancies following CAR-T cell immunotherapies. Review the key points of this announcement concerning the CGT research community.
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Understanding Potency In Gene Therapy Development
2/28/2024
Explore the importance of understanding potency in cell and gene therapy (CGT) development and the challenges in developing potency assays for CGT products.
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Optimizing AAV Purification for High Recovery
2/27/2024
How can you improve purification methods for your AAVs and enhance the efficacy and safety of your gene therapy treatments?