Factors Influencing CD34+ Cell Collection Efficiency In Leukapheresis: Insights From Recent Studies

Blood stem cell transplantation, particularly peripheral blood stem cell (PBSC) collection via apheresis, has evolved as a standard treatment for hematological disorders, offering advantages such as faster recovery and improved overall survival. Challenges in PBSC collection involve balancing factors like procedural efficiency, patient comfort, and staff resource optimization while acquiring an adequate number of hematopoietic progenitor cells. A pivotal aspect is the development of customized prediction algorithms for individual centers, considering various factors such as patient demographics, transplantation goals, and mobilization strategies.

This article discusses factors influencing leukapheresis efficiency, drawing on analyses from recent studies. These factors span peripheral blood parameters, patient characteristics, device settings/procedures, and the impact of mobilization agents. Ongoing research aims to comprehensively understand the intricate dynamics influencing the efficiency of leukapheresis in blood stem cell transplantation.