Real-Time Monitoring Of Solvent Clearance By Tangential Flow Filtration In The Antibody-Drug Conjugate Process Using Raman Spectroscopy

This application note explores the implementation of Raman spectroscopy as a powerful analytical tool for monitoring the solvent clearance step during the manufacturing of Antibody-Drug Conjugates (ADCs). By enabling in-line and real-time analysis, Raman spectroscopy offers a transformative approach to process monitoring and control. The integration of this technology into ADC production not only enhances the ability to determine optimal process conditions but also accurately identifies the endpoint of the diafiltration step. This advancement supports both process development and routine manufacturing by ensuring consistency, efficiency, and compliance with stringent regulatory standards.

Learn how the adoption of such innovative methodologies contributes to the production of high-quality therapeutics, which improves treatment outcomes and offers better options for patients.