Newsletter | January 24, 2024

01.24.24 -- 6 PEG Alternatives You Should Be Thinking About

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FEATURED EDITORIAL

6 PEG Alternatives You Should Be Thinking About

PEGylation is a common way to minimize off-target effects and general toxicity, but it also poses life-threatening risks because it prolongs the drug's time in the bloodstream. Scientists are exploring these alternatives to combat the risk.

Panacea To Precision To Personalized Medicine: Computational Biology's Drug Development Potential

In biopharma, the potential reverberations of AI and ML are profound, creating nearly infinite opportunities for drug discovery to become more tailored, specific, and beneficial for patients.

INDUSTRY INSIGHTS

Enabling Next-Generation Biomanufacturing Using Cell-Free Technology

Leveraging the flexibility of cell-free technology, as well as process development and manufacturing infrastructure, can unlock the potential of difficult-to-manufacture protein therapeutics.

A CDMO's Mission To Empower Emerging Biotechs

Learn how a CDMO that respects the unique manufacturing needs of early-stage companies and small-scale programs is promoting innovation and modeling what true partnership looks like.

Prioritizing Speed In Drug Therapy Development And Moving Fast Safely

What factors should drug therapy sponsors take into consideration when working to accelerate the delivery of transformative therapies, while also maintaining safety and upholding efficacy standards?

Utilization Of Titration Curve Modeling In Bioassay Potency

To overcome growth condition variability and the plotting of titration curves to measure any effect on the targeted mechanism of action, explore a modeling tool to predict cellular response.

Mammalian Bioreactors: A Characterization Data Report

Review experiments that characterize the basic operating conditions of mammalian cultures in single-use bioreactors and parameters to be used when transferring cultures to and from other bioreactor systems.

Scale-Up Of Ex Vivo Erythroblast Expansion For The Production Of RBCs

This study demonstrates the first steps toward the scaling up of erythroblast expansion in a GMP-compatible bioreactor setup.

A Strategic Approach To Purchasing And Integrating Solid-Dose Equipment

Acquiring pharmaceutical processing equipment and successfully integrating it into operations is not as straightforward as it may seem. 

Four Special Fill/Finish Considerations For Vaccine Production

Examine considerations regarding the handling and process for fill/finish to ensure the stability and purity of your vaccine as well as limit unnecessary waste and cost.

How To Clean Your Incubator Shaker

Cleaning an incubator shaker is critical for successful cultivation, and integrating this type of maintenance into the routine management of your biosciences laboratory doesn't have to be difficult.

Embracing GMP Manufacturing To Meet Pharma’s Future

As pharma companies aim to overcome development obstacles, it is important to incorporate GMP expertise alongside novel technologies that can enhance the properties of APIs and dosage forms.

The Linchpin In Successful Biotherapeutic Development

Review key factors for building a reliable CLD strategy and learn how the right CDMO can help you achieve the high quality, high yield, and speed needed to successfully bring a biologic to market.

Improve Scalability And Manufacturability Of A Cytotoxic ADC

This case study details which process conditions and protocols were chosen as optimization targets and the resulting improvements to ADC production and purification provided by assessing these parameters.

Viral Vector Scale-Up: How Can We Bridge The Technology Gaps?

Unlocking the full potential of viral vector-based therapies requires an understanding of existing challenges in viral vector production and what technologies are now available to help address them.

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