Upstream Manufacturing

INSIGHTS ON UPSTREAM MANUFACTURING

Upstream Process Intensification With Dynamic Perfusion
A fixed-feed approach to perfusion offers a simpler route to intensification, matching steady-state productivity at 50 L scale while consuming less media and requiring fewer operator interactions.
Designing ADC Manufacturing For Operator And Patient Safety
ADC manufacturing succeeds when manufacturability is treated as an early design input. Cell line choices, toxic payload handling, and single-use extractables each shape operator exposure and risk.
Simplifying Custom Media From Development To GMP With An End-To-End Approach
Custom media manufacturing across US and European sites, paired with rapid prototyping of proprietary formulations as a scale-down model, shapes how teams move cell culture processes toward GMP production.
Flexible Automation For Bioprocess Development And Quality Control
Flexible lab automation can standardize experimentation across upstream process engineering and downstream quality control, while staying adaptable as process requirements shift.

Expanding The Transposase Toolkit For Cell Line Engineering
11/6/2026

Combining distinct transposase systems in one cell line opens engineering options beyond single-system insertion, including control over glycosylation, enzymatic function, and more.
Rethinking Expression To Accelerate Antibody Discovery
11/5/2026

Expression often limits high-throughput antibody discovery because functional screening needs soluble, correctly folded protein. Explore how moving expression into screening changes which candidates get tested.
Exciting Advances In Cell Line Development
11/5/2026

In this segment from the Bioprocess Online Live event, “Critical Decisions Driving Next-Generation Cell Line Development,” panelists Ted Peters, Ph.D., and Ronan O’Kennedy, Ph.D., discuss the trends or advancements that excite them the most, which include a deeper understanding of CHO cell biology and the industry-wide push towards continuous manufacturing.
When To Shift To A Master Cell Bank
11/5/2026

In this segment from the Bioprocess Online Live event, “Critical Decisions Driving Next-Generation Cell Line Development,” panelists Ted Peters, Ph.D., and Ronan O’Kennedy, Ph.D., answer audience questions pertaining to master cell banking (MCB) and technology transfer.

Complex ADC Development. Simplified. One Coordinated European Platform

Successful targeted oncology programs combine biological engineering, potent compound synthesis, and efficient manufacturing to reduce complexity and speed clinical progress.
TheraPEAK® ActiCell® T Cell Activation Reagent

Bead-free activation of human T cells through biodegradable nanoparticles aims to protect cell health during expansion, with the reagent cleared by simple washing or centrifugation.
Quantum Flex Cell Expansion System: Inspired By Human Biology, Designed To Scale

Cell expansion built around low seeding requirements and high yields in 1 L or less. A bioreactor design drawn from human biology aims to simplify scale-up.
Guaranteed Tech Transfer And Process Development – Or Your Money Back

De-risk biotech development with guaranteed tech transfer and process support. Safeguard your investment from cell line development through protein optimization.
Nunc Cell Factory Systems: For Consistent Cell Culture Performance

Scaling adherent cell culture from flasks to multilayer systems depends on surface consistency, aseptic connections, and more. See how ultrasonic welding and retention hardware shape that path.