Upstream Manufacturing

INSIGHTS ON UPSTREAM MANUFACTURING

Collaborating For Supply Chain Resilience
Cell culture media supply resilience shapes continuity. A global CDMO's approach to tariff exposure spans both proprietary formulations and standard media, showing how supply strategy holds up.
Enabling Commercial-Scale Biologics Manufacturing With Media Services
Consistent cell culture media across development underpins reliability at scale. Integrated manufacturing addresses supply, quality, and shelf-life uncertainty that can ripple into commitments.
Rethinking Starting Material: Whole Blood For Autologous T-Cell Manufacture
Matching starting material to process requirements in autologous T-cell manufacturing, and where whole blood may stand in for leukapheresis without compromising what the process needs.
3-In-1 Protocol For Rapid CAR-T Cell Manufacturing
Closing the process and merging three steps into one perfusion run brings CAR-T manufacturing down to roughly a week, with fewer open events and lower batch failure risk.

A Robust System For High-Titer, Platform-Agnostic AAV Production In HEK293 Cells
10/23/2026

AAV titer and full capsid enrichment depend on tuning every process component, starting with the medium. Results across serotypes, reagents, and enhancers show how far a media-led approach can go.
Maintaining Process Consistency And Performance During Scale-Up
10/22/2026

See how an intensified N-1 perfusion process maintained stable cultures, reproducible cell expansion, and aligned mAb production across 5 L, 50 L, and 500 L scales while supporting viable cell densities.
Maximize Exosome Yields Using a Chemically Defined Bioreactor Media System
10/22/2026

See how scalable processes can improve exosome yield and recovery while maintaining critical quality attributes and supporting clinical manufacturing.
High-Throughput Binding Affinity Assessment Using Octet® HTX
10/22/2026

Binding affinity screening of clones directly from crude supernatant, without purification, changes what can be assessed early, and a tiered workflow pairs broad throughput with deeper analytical characterization.

Quantum Flex Cell Expansion System: Inspired By Human Biology, Designed To Scale

Cell expansion built around low seeding requirements and high yields in 1 L or less. A bioreactor design drawn from human biology aims to simplify scale-up.
Guaranteed Tech Transfer And Process Development – Or Your Money Back

De-risk biotech development with guaranteed tech transfer and process support. Safeguard your investment from cell line development through protein optimization.
Nunc Cell Factory Systems: For Consistent Cell Culture Performance

Scaling adherent cell culture from flasks to multilayer systems depends on surface consistency, aseptic connections, and more. See how ultrasonic welding and retention hardware shape that path.
Viral Vector CDMO Services From Design To GMP Delivery

Integrated viral vector development, testing, and GMP supply, paired with engineered plasmids and cell lines to reduce scale-up risk and improve yield.
GMP-Ready Mammalian Cell Line Development Platform

Optimizing vector, host, and process together can shorten the path from stable pool to GMP while keeping titers and quality consistent across 50L to 2,000L scales.