INSIGHTS ON UPSTREAM MANUFACTURING
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![GettyImages-2187764040-cell-culture-testing-manufacturing-in-lab]( "CHO K1 Cell Culture Process Intensification For Enhanced Production Of IgG mAbs")
CHO K1 Cell Culture Process Intensification For Enhanced Production Of IgG mAbsDiscover how our optimized CHO K1 cell lines achieved up to an 80% increase in titer while maintaining product quality through molecule-specific process development strategies.
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![GettyImages-1648451466-scientist-cell-culture-laboratory-pipette-research]( "The Science Of Cell Line Development For Biologics")
The Science Of Cell Line Development For BiologicsSelecting and engineering the right cell line is not simply a technical milestone; it is a strategic decision that shapes cost of goods, development timelines, and the overall probability of success.
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![Flexibility Or Scale?]( "Flexibility Or Scale? Navigating The Single Use Vs. Stainless Steel Debate")
Flexibility Or Scale? Navigating The Single Use Vs. Stainless Steel DebateExplore how to choose between single‑use and stainless‑steel bioreactors, outlining key advantages, limitations, and long‑term considerations essential for successful biologics scale‑up.
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![GettyImages-2192786673 antibodies]( "Integrated Upstream And Downstream Strategies For Robust mAb Manufacturing")
Integrated Upstream And Downstream Strategies For Robust mAb ManufacturingProcess robust mAb production requires understanding scale dependent cell environments, leveraging predictive models, and pursuing data driven control to minimize variability, optimize quality, and ensure reliable technology transfer across biomanufacturing scales.
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Rapid Discovery Of CD200R1 Antagonist VHHs Via Single B Cell Technology2/4/2026
Here, we used single B cell antibody discovery to rapidly identify a diverse set of potent, high-affinity, neutralizing VHH from immunized llamas against CD200R1, an emerging therapeutic immune checkpoint target.
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Bispecific Antibodies Unleashed2/4/2026
Explore how leveraging expert CDMO partnerships can streamline the development process and enhance the efficacy of your bispecific antibody therapies.
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Leveraging Efficiency From CLD To Clinical Manufacturing Of mAbs2/4/2026
Discover how our efficient strategies can propel your mAb from discovery to clinical manufacturing in as little as 18 months.
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Flexible Cell Culture Media For High Titer Production Of AAV In HEK 2932/4/2026
To maximize the results of viral titer and full capsids, it's necessary to undertake systematic process development and optimization of AAV production. The choice of cell culture medium is foundational.
UPSTREAM MANUFACTURING SOLUTIONS
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![Repligen - XCell]( "XCell® ATF System")
Simplify and intensify upstream bioprocessing. The XCell® ATF System, in single-use or stainless steel format, delivers superior cell retention. High impact upstream applications include N-1 perfusion, high productivity harvest, long-term perfusion and seed train intensification.
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![KrosFlo TFDF]( "KrosFlo® TFDF System")
Game-changing TFDF® (Tangential Flow Depth Filtration) technology that simplify and intensify upstream viral vector bioprocessing, ideal for AAV, lentivirus, oncolytic, retrovirus, adenovirus, exosomes, and cells on microcarriers.
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![Repligen - XCell]( "Breaking Productivity Barriers In Upstream Bioprocessing")
Learn about innovative cell retention technology that supports continuous bioprocessing through perfusion cell culture, allowing for longer run times, higher product yields, and reduced costs.
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![GettyImages-506999858-scientists-cell-culture-lab-development]( "Accelerating CHO Bulk Harvest Testing Requires Rapid Methods")
Reduce testing timelines from weeks to days with advanced viral detection, as well as achieve faster lot release and regulatory alignment while maintaining safety and compliance for CHO-based processes.
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![Asahi Kasei - THESYS OS]( "Oligosynthesizers For Solid Phase Oligonucleotide Synthesis")
Learn about high-performance and scalable THESYS OS oligosynthesizers, which feature advanced process controls and automation for efficient and reliable oligonucleotide synthesis.
