INSIGHTS ON UPSTREAM MANUFACTURING

• Behind The Data: Engineering Hepatocyte-Targeted LNPs

  See how lipid nanoparticle platforms can deliver RNA and large DNA payloads to primary human T cells, improving transfection, expression durability, and CAR insertion efficiency.

• Behind The Data: Comprehensive Off-Target Assessment Strategies

  Explore how biochemical, computational, and cell-based methods can identify, confirm, and interpret off-target editing risks, providing a more complete safety assessment for CRISPR-based therapeutics.

• A Novel Non-Viral Platform For High-Efficiency T-Cell Engineering

  Gain insight into how nuclease format, delivery method, and DNA template design influence knockout efficiency, targeted TCR integration, cell viability, and recovery.

• Discovery And Validation Of High-Efficiency Large Serine Recombinases

  Novel large serine recombinases demonstrate efficient targeted gene insertion across mammalian cell types. Learn how bioinformatic discovery can expand the toolkit for delivering large payloads.

• Discovery And Validation Of Novel Large Serine Recombinases

  9/22/2026

  Discover how bioinformatics, machine learning, and protein engineering can advance programmable gene insertion, with novel recombinases demonstrating strong mammalian-cell activity.

• Why Isn't One Assay Enough For Gene Editing Off-Target Safety Assessment?

  9/22/2026

  Gene editing off-target risk cannot be captured by one assay. Combining biochemical, computational, and cell-based methods with deep sequencing provides a more complete view of potential edits.

• Challenges And Opportunities For MSC Expansion Workflows

  9/22/2026

  Discover how optimizing cell culture platforms and closed systems reduces manufacturing costs, improves media efficiency, and supports scalable stem cell production.

• Improving Scale-Up Starts With Expression Strategy

  9/21/2026

  Early expression screening and strain-engineering strategies can reveal manufacturing risks and clarify which recombinant protein candidates are worth advancing before major investments are made.