INSIGHTS ON UPSTREAM MANUFACTURING
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Analyzing Serum-Free Media For Cell Therapy Applications
Identifying critical factors and their concentrations with an eye towards designing an ideally formulated, defined serum-free medium should be carried out using rational and systematic approaches.
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Metabolite Analysis In Cell Therapy Development
Understand the importance of metabolic analysis in cell therapy, optimizing cell culture media formulations, and enhancing the effectiveness of CAR T-cell therapy and stem cell transplantation.
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Idea To Clinic: Accelerate Your Manufacturing Timeline To FIH Studies
Translating novel drug discoveries into clinical trials remains a complex endeavor. Learn how a CDMO with cutting-edge technologies can facilitate a smooth path from discovery to FIH studies.
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A Century Of Cell Culture And The Rise Of Organ-Chips
Despite its advantages in researching biological processes, 2D cell culture suffers from its artificial nature. Learn about 3D cell culture and how it is advancing in vitro studies.
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In Vitro Vs In Vivo: A History Of Modern Cell Culture3/8/2024
Explore the origins of modern cell culture as well as the advantages and disadvantages of in vitro and in vivo studies.
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High-Titer rAAV Production In Bioreactors Using Producer Cell Lines3/6/2024
Here, we detail the upstream process development and optimization for an AAV8-GFP proof-of-concept (PoC) producer single cell clone (SCC) in both batch and perfusion modes.
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Producer Cell Line For Large-Scale Viral Vector Manufacturing3/6/2024
Embrace the future of gene therapies and overcome challenges in large-scale viral vector manufacturing with a one-step process that ensures robustness and scalability.
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Cost Modeling Comparison Of Bioreactors To Produce Adherent Cell Products3/6/2024
This study employs BioSolve software, a reference for cost analyses in the biopharmaceutical industry, to compare the upstream manufacturing costs between multitray stacks and the iCELLis™ bioreactor.
UPSTREAM MANUFACTURING SOLUTIONS
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Discover a true producer cell line where Rep, Helper, Cap, and the gene of interest are stably integrated into the host cell's genome, requiring only a single induction step to initiate AAV production.
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Delivering on the promise of AAV-based gene therapies beyond rare diseases will require large quantities of high-quality AAV, produced in a robust manner.
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Explore seed train intensification, a transformative approach to cell culturing, and process solutions that enable you to amplify your cell banks.
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Our services gather information about amino acids, trace elements, water-soluble vitamins and other analytes of interest e. g. glucose, lactate, and ammonium present in your sample
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Discover a versatile and modality-agnostic aseptic autosampling solution designed for reliable on-line sample analysis in near real-time without the need for manual intervention.