INSIGHTS ON UPSTREAM MANUFACTURING

• Saving Time And Money With Better Microbial Strain Selection

  Deeper, automated E. coli screening can reduce cell line development costs by narrowing the design space, lowering the marginal cost of additional experiments, and improving downstream productivity through higher titers and cleaner harvests.

• How Perfusion In Seed Train Bioreactors Can Simplify Upstream Processes

  N-1 perfusion achieved approximately 95% viability while scaling from bench to production. See how this approach intensified seed trains without affecting subsequent fed-batch performance.

• Using Computational Fluid Dynamics To Design Scalable Processes

  Learn how CFD modeling and experimental data can be combined to assess power input, mixing, oxygen transfer, and more across bioreactor scales, supporting sound process decisions.

• Driving Optimization Through Connected Laboratory Environments

  Discover how connected laboratory data and predictive modeling can strengthen process control, improve yield, and more, creating a faster and more resource-efficient approach.

• When Your Expression System Isn't Cooperating With Your Protein

  8/26/2026

  When a protein resists an established expression system, the issue may be host-platform mismatch rather than a fundamentally difficult molecule.

• A Comprehensive Solution With Targeted And Non-Targeted Approaches

  8/26/2026

  Explore how non-targeted NGS and targeted molecular assays can work together during cell line characterization to provide broad virus detection while supporting evolving regulatory expectations.

• Characterizing Process Performance And Robustness In An End-To-End Cryopreserved Autologous CAR-T/TCR Workflow

  8/25/2026

  A systematic evaluation of an end-to-end cryopreserved CAR-T workflow examines how critical process parameters and unit operation interdependencies affect manufacturing consistency and robustness.

• Driving Measurable Productivity Gains In CHO Cell Culture

  8/25/2026

  Explore how targeted media supplementation can improve CHO cell culture outcomes, simplify process optimization, and increase productivity across monoclonal antibodies and emerging modalities.