The stirred-tank reactor is the most commonly utilized reactor type in biotechnology. Read more about the Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.). It is designed as a stirred-tank reactor for animal cell culture and has the unique advantage of utilizing completely single-use product contact surfaces.
See how this solution not only provides additional capital savings but will also resolve potential manufacturing floor space limitations.
Read how the Eppendorf BioBLU 5p Single-Use Vessel prepacked with Fibra-Cel disks is an excellent platform for high-density Vero cell culture.
Researchers at Cevec® Pharmaceuticals adapted a small scale shake flasks rAAV production process to stirred-tank bioreactors and scaled it up in BioBLU Single-Use Vessels from a working volume of 2 L to 10 L. Scale-up in bioreactors was based on constant power input/volume. It led to comparable cell growth and virus production at both scales and to the original shake flask process.
This article examines some of the currently available schemes used in generating rAAV from suspension cultures, and describes what it takes to achieve scalable rAAV production.
Early collaboration and open communication between upstream and downstream are crucial to ensure a consistent end-to-end bioprocess.
Watch this video from Pall Biotech to learn about the advantages of single-pass tangential flow filtration versus traditional tangential flow filtration.
This video will give you an introduction on the Xuri™ W25 cell expansion system. You’ll get an overview of the system control capabilities which make it suitable for use in a regulated environment, and its flexibility to handle multiple indications with various cell types.
This video provides and overview on the Sefia™ cell processing system, The overview will show the intuitive interface with augmented process control and integrated traceability, easy to implement at your cell therapy activities.
This video provides an introduction to the Sepax™ C-Pro, cell processing system, showing how to start a procedure and preparing and installing the corresponding kit.
Watch this video to learn the important decisions that each biopharma executive must make to break down roadblocks during the critical first step of cell line development and bring their molecule to clinic successfully.
A next-generation bioprocess control station, designed as a universal platform capable of meeting the ever changing needs of all segments of the biotech and pharmaceutical sciences.
The Thermo Scientific™ HyPerforma™ Glass Bioreactors are available in 1, 3, 7, and 15 L sizes. They offer easy operation and rapid assembly and are manufactured with the highest standards for materials and surface finish. Developed using a computational fluid dynamics (CFD) simulator, the HyPerforma Glass Bioreactor impellers provide maximum mixing with minimum shear force, resulting in a higher average kLa. The cold finger has been replaced by a cooling loop to increase the thermal surface. Laboratory performance tests have demonstrated a cooling rate two times better than a sample of products from other suppliers. Control can be bidirectional, which allows a single-wall vessel to be used for mammalian applications and fermentation processes* (needs two kits).
Read more about solutions offered from Thermo Scientific including the HyPerforma™ G3Lite™ Controller, TruBio upstream software, HyPerforma S.U.B., TruFlow gas mass flow controller (MFC) and other products for your process development and production operations.
Flexible, reliable, and configurable bioprocessing solutions
The Thermo Scientific™ HyPerforma™ G3Lite™ Controller is an open architecture control system that can be integrated with any single-use bioreactor such as the Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.) (Available in sizes ranging from 50 L to 2,000 L). The system consists of a control tower that leverages intelligent transmitters, mass flow controllers (MFCs), pumps, sensors, and Thermo Scientific™ TruBio™ software that facilitates easy, reliable, and repeatable process development and commercial cell culture processes. HyPerforma G3Lite Controllers are fully self-contained, movable units that can be operated as stand-alone (for 1 vessel) or networked for multiple vessels. They are engineered to optimize capital cost for use in non-GMP and cGMP-certified production facilities.