INSIGHTS ON UPSTREAM MANUFACTURING

• Enhanced Biotherapeutic Protein Expression Using Advanced Vector Systems

  Learn how optimized expression vector design and data-driven strategies can significantly enhance product titre, quality, and long-term gene expression stability in GS-CHO cell-based manufacturing.

• In Vitro Transcription For mRNA Production

  Efficient mRNA production relies on optimized IVT conditions, where NTPs, enzymes, and critical additives work together. Explore how the right components strengthen mRNA synthesis at every step.

• Go Beyond Custom Media Screening And Prototyping

  Learn about manufacturing solutions that streamline cell culture media scale-up with global production capabilities, equivalency strategies, and quality assurance for reliable supply.

• Take The Lead With The Gibco CHOvantage™ GS Cell Line Development Kit

  See how this kit accelerates clone development to 14 weeks with ≥7 g/L protein titers while reducing costs through royalty-free commercial licensing for therapeutic applications.

• Extracellular Secretion Of Recombinant Proteins: Proof-Of-Principle Data

  3/10/2026

  Explore experimental approaches to extracellular protein secretion that streamline recovery and improve product quality. See proof-of-principle data across multiple protein types and molecular weights.

• Extracellular Protein Secretion Into The Culture Media: A Lever In Microbial Expression

  3/10/2026

  Explore how engineered microbial hosts enable extracellular protein secretion, bypassing lysis to deliver cleaner starting material and faster recovery across multiple therapeutic modalities.

• The Importance Of Process Locks To Align Upstream And Downstream

  3/9/2026

  In this closing segment from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration,” the panelists emphasize the importance of periodic process locks to ensure alignment between upstream and downstream development teams. These locks are critical, says Eric Doerr, a manufacturing lead at Sanofi, because they allow both upstream and downstream to have a better understanding of the process and keep them on the same page.

• Feed Media Can Significantly Impact Process Performance

  3/9/2026

  In this segment from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration,” our panelists respond to an audience question about feed media and its impact on process performance.