• A Balanced Diet: Feeding Bioreactor Cultures

    When culturing cells, scientists need to account for the cost of supplies, process runtime, desired product yield and quality, and the organism being cultivated when designing appropriate feeding strategies. Understanding the strengths and weaknesses of each feeding strategy aids in designing efficient experiments with optimal results.

  • How Do Bioreactors Boost Reproducibility?

    Bioreactors are not merely inert vessels for cell growth; they closely monitor and dynamically adjust biological and mechanical process conditions automatically. Options for vessel size, control sensors, and pumps in modern bioreactors make them ideal growth containers for a variety of cell types. Controlling reaction environments using software enables better control and data collection throughout the growth phase.

  • The Next Level: Why Move To A Bioreactor?

    Moving beyond the incubator and shaker to bioreactors and fermentors allows scientists to create and monitor ideal environments for cellular reproduction and product formation, increasing experimental yields and enhancing reproducibility.

  • Easy Perfusion For Anchorage-Dependent Cell Culture

    Anchorage-dependent cells, such as Vero cells, are widely used as a platform for viral vaccine production. This application note demonstrates an excellent platform for high density Vero cell culture.

  • Process Optimization And Scalability Evaluation Of Pellicon® Capsules For Single-Pass Tangential Flow Filtration Of mAb-Based Biomolecules

    SPTFF has been successfully implemented between unit operations throughout the downstream production process of biopharmaceuticals. Its value lies in the simplicity of operation as well as its small footprint and equipment requirement. This document describes the principles of SPTFF and how to determine operating conditions to achieve the target concentration factor with single-use Pellicon® Capsules.

  • Next Generation Bioprocessing And The Implications For Viral Safety

    With many companies embracing the move to next generation biopocessing, it is important that they do not forget to re-examine their approach to viral safety.

  • The Holistic Approach To Upstream Viral Safety

    There could be significant benefits to implementing additional measures in upstream bioprocesses to prevent viral contamination. But, given that upstream processes are complex, multiple strategies and technologies must be integrated within a holistic risk management program.

  • Reduce The Level Of Host Cell Protein In The Bioreactor Harvest

    Host cell proteins (HCPs) are an inevitable byproduct of biologics manufacturing and can have an impact on product quality and efficacy as well as patient safety. Processes designed to remove HCPs from the bioreactor harvest must not only be successful in achieving acceptable limits, but also be scalable. Learn how we helped our client reduce the level of HCPs in the bioreactor harvest prior to a production run to supply drug substance for a scheduled Phase 1 clinical trial in a very tight timeline.


  • Saltus® Single-Use Mixing System Brochure

    Saltus® mixing systems are based on a design philosophy which emphasizes usability and automation. From the easy to install, self-deploying, single-use mixing assembly to the fully automated, one-button start of the control system, Saltus® mixers provide unparalleled usability and ease of operation.

  • Saltus® Single-Use Mixing System

    Next generation single-use mixing for liquid-liquid and powder-liquid applications.

  • Motion Bioreactor Bags: Single, Double, And Triple Barrier Cell Culture Bags

    Bringing the benefits of ultimate customization, fast design, and delivery to cell culture applications, Entegris offers the motion bioreactor bag.

  • HyPerforma DynaDrive Single-Use Bioreactor (S.U.B.)

    The Thermo Scientific™ HyPerforma™ Single-Use Bioreactor (S.U.B.) is one of the most widely used S.U.B.s designed for mammalian cell culture. The HyPerforma S.U.B. has been widely adopted in process development (PD) and clinical trials, as well as in bioproduction of cGMP cell culture. The new Thermo Scientific™HyPerforma™ DynaDrive™ S.U.B. is the latest advancement based on our proven innovation, which offers better performance and accommodates larger volumes.

  • BioContinuum™ Platform Key Focus Areas

    This brochure highlights the different BioContinuum™ platforms for seed train, production and harvest, flow through polishing, ultrafiltration, and buffer management.