INSIGHTS ON UPSTREAM MANUFACTURING
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![908 Devices - amino acid analysis]( "Amino Acid Analysis Indicates Metabolic Differences In MCB CAR T-Cells")
Amino Acid Analysis Indicates Metabolic Differences In MCB CAR T-CellsExploring the metabolic differences in CAR T-cells activated with multi-cytokine backpacks (MCBs) reveals correlations between CAR T-cell activation, nutrient metabolism, and efficacy.
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![908 Devices - maverick]( "Instant PAT Implementation Across Cell Lines, Media, And Scales")
Instant PAT Implementation Across Cell Lines, Media, And Scalesexplores how MAVERICK’s Raman-based technology delivers instant, reliable measurements of glucose, lactate, and biomass across diverse cell lines, media, and scales.
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![Considerations in depth filter]( "Considerations In Depth Filter Scale-Up")
Considerations In Depth Filter Scale-UpExplore study findings aiming to assist process development scientists and engineers in understanding the structure of depth filter capsules, identifying key parameters for development, and more.
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![Virus Filtration]( "Virus Filtration: Regulations And Mechanisms")
Virus Filtration: Regulations And MechanismsIn this presentation, Dr. Nigel Jackson, Principal Engineer in R&D, offers an in-depth discussion on regulatory guidance and recent updates pertaining to virus filtration.
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Successful DPM Manufacturing- Development To Large-Scale cGMP Production7/25/2024
This study showcases the success of a two-phase scale-up strategy for the production of dry powder medium (DPM).
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Overcoming Challenges To The Commercialization Of Lentiviral-Based Therapies7/24/2024
Review the results obtained for our proprietary HEK293T 2G7 suspension cell line for LVV production by transient transfection in serum-free, chemically-defined and animal component-free media.
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Enabling Commercial AAV Manufacturing By AAV Stable Producer Cell Lines7/24/2024
A high-performance, helper virus-free stable producer cell line is derived from proprietary high-producer HEK293 cells and is cultivated in a chemically defined, serum-free, ADCF medium in suspension.
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Novel Engineered Plasmids And Optimized HEK293 Cell Line Improves AAV Productivity7/24/2024
Low AAV productivity and lack of platform processes continue to be key challenges driving AAV production cost up. Explore a robust and scalable suspension manufacturing platform for AAV production.
UPSTREAM MANUFACTURING SOLUTIONS
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![GettyImages-1322096218-- AAV- Adeno-associated]( "Ramp Up Your AAV Production With The Xcite® AAV Platform Technology")
Xcite™ AAV platform technology is established based on our proprietary suspension HEK293 cell line and plasmid vectors, proven to enhance AAV production.
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![Eppendorf New Brunswick CelliGen BLU Bioreactor]( "Used Eppendorf Bioreactor: CelliGen BLU")
Used Eppendorf New Brunswick CelliGen BLU Bioreactor, Single Use Vessel/Stirred Tank Bioreactor, Uses Consumable Hard Plastic Reactor vessels with Integrated Agitators, Servo Agitator Drives are Part of Main Controller, with Integrated Peristaltic Pumps, 120v, S/N BBLUCG701671
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![300L Thermo Scientific Single Use Fermenter]( "Used 300 Liter Thermo Fisher Scientific Single Use Fermenter")
Used 300 liter ThermoScientific Single Use Fermenter, type 300L HyPerforma, part# SUF0300.6232, with Hyperform G3 Lite Controller, stainless steel jacketed bag support container, jacketed for 150 psi at 150 f, with hinged bioprocess container door, certified by Anderson Dahlen, serial# ADIAT10, national board# 1278, built 2020, top mounted 2 hp agitator drive, external condensor, Thermo Scientific serial# AD33332, built January 2021.
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![500 Liter Thermo Scientific IMPULSE Single-Use Mixer]( "Used 500 Liter Thermo Fisher Scientific Single Use Mixer: Impulse")
Used 500 liter Thermo Scientific imPULSE single use mixer, part# IM00500.6033, stainless steel construction, 500 liter stainless steel bag holding vessel, full hinged side access door with window, jacketed vessel rated 150 psi at 150 f, certified by Cone Craft, serial# H20346-01, national board# 1458, bottom mounted reciprocating mixer drive, side mounted control system with Allen Bradley PanelView Plus touchscreen controller and plc controllers, on stainless steel frame with load, system serial# H20346-01, built 2021.
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![1250 Liter ABEC Fermenter]( "Used 1,250 Liter ABEC Fermenter / Bioreactor")
Used 1250 liter ABEC fermenter reactor, 316L stainless steel construction, approximately 42" diameter x 63" straight side, dish top and bottom, rated 45 psi and full vacuum at 350 f internal, jacketed for 150 psi and full vacuum at 350 f, bottom mounted agitator drive, on 3 legs, serial# PJS001925, national board# 1696, built 2018.
