INSIGHTS ON UPSTREAM MANUFACTURING

  • An Integrated Single-Use Platform for Manufacturing Plasmid DNA (pDNA)

    Plasmid DNA (pDNA) plays a critical role in the delivery of gene therapies into targeted cells. The development and delivery of large quantity, high-quality pDNA vectors are in high demand. Cytovance has developed and integrated Single-use Platform for manufacturing Plasmid DNA (pDNA) using the HyperGRO™ high cell density process that is licensed from Nature Technologies, an industry leader in the field.

  • Alternatives To In Vivo Assays For Biosafety Testing Of Biologics

    The use of animal models for the detection of adventitious agents has been a feature of biologic testing packages for many decades. However, as alternative methods such as PCR and NGS have emerged these in vivo tests have stubbornly remained a central part of testing. Here we examine the current in vivo methods and explore alternatives which can be employed today.

  • End-User Evaluation Of 30 L And 300 L HyPerforma Single-Use Fermentors And Scale-Down Model

    In moving processes from bench to pilot and ultimately production fermentors, it is critical to have a reliable scaledown model. Scale-down models can vary depending on the media, strain, and process conditions. In this case, a customer wanted a scale-down model of the Thermo Scientific™ HyPerforma™ Single-Use Fermentor (S.U.F.) in order to establish what fermentation processes could be scaled into the S.U.F., in particular for the production of plasmid DNA.

  • Use Of Nunc Cell Factory Equipment To Accelerate Workflows And Increase Product Consistency

    Scaling up adherent cell culture can be a difficult process for many vaccine, cell therapy, gene therapy, and viral vector manufacturers. Some cells can alter their properties if they are not cultured in specific conditions. The simplest way to mitigate all these risks is by using a multi-layered vessel, such as the Thermo Scientific™ Nunc™ Cell Factory™ system, in a closed system with automation equipment.

UPSTREAM MANUFACTURING SOLUTIONS

  • Nunc Cell Factory Automated Equipment Brochure

    An integrated solution for Cell Factory systems.

  • Technical Guide To Peptones, Supplements, And Feeds

    The Gibco™ technical guide to peptones, supplements, and feeds was developed as an easy-to-use reference tool to provide technical information and guidance in the selection of performance enhancing products for use in cell culture and microbial fermentation production,

  • BIOSTAT STR® Generation 3 Bioreactor With BIOBRAIN

    BIOSTAT STR® single-use bioreactors and the BIOBRAIN automation platform are engineered to allow you to rapidly adapt your biomanufacturing facility to address changing requirements by offering multiple configurations and convenient software upgrades. The generation 3 system is now available with native DeltaV™ and access to our best in class BioPAT® toolbox.

  • Bio-Plex Pro Human Immunotherapy 20-Plex Panel

    The Bio-Plex Pro Immunotherapy 20-Plex Panel detects and quantifies a mix of cytokines, growth factors, and other valuable markers to provide insight during the discovery, development, and monitoring of immunotherapies.

  • SciVario® twin Bioprocess Controller

    The SciVario twin is a future proof bioprocess controller, developed by Eppendorf, with the intuitive VisioNize®-onboard software, bringing the digital age to the laboratory.