By recognizing the limitations of today’s production processes, the industry may be able to overcome the challenges, complexity, and high cost of manufacturing vaccines and viral vector-based therapies.
Smart bioprocessing uses bioinformatics, lab-scale processing, and analytics to create efficient and cost-effective production processes that can be verified at lab-scale before scale-up.
Bioprocessing development is a long and costly process. Building in continuous characterization and connected bioprocessing cuts timelines and increases the available information through real-time analytics.
Using a case study, the author demonstrates how comparative statistical analysis enabled his team to improve the yield of a component used in API synthesis by more than 2.5 x 108 U/batch.
Read why Fibra-Cel disks are a promising alternative attachment matrix with a high surface-to- volume ratio and provide a three-dimensional environment that protects cells from damaging shear forces, helping to achieve high cell densities.
Parallel operation of multiple bioreactors and the use of single-use equipment can help reducing development times and ultimately costs.
A webinar to learn about challenges faced with traditional expression systems and how a CHO cell line with the glutamine synthetase knock-out via ZFN provides benefits for fast, efficient cell line development with stable and high titer expression.
Learn about polishing technologies that enable a fully flow through polishing platform and how implementation of next generation processing can positively impact facility fit limitations.
Explore the economic benefits when using a cell culture medium designed specifically for perfusion processes and the proactive risk measures suppliers need to take to facilitate the manufacturer’s business continuity and product quality.
A platform that combines drug development expertise and biomanufacturing and integrated services to offer advantages to ADC developers.
Using workflow based software solutions to guide scientists through various processes in low to high throughput screening campaigns.
In this webinar Joaquina Mascarenhas, Ph.D. of Milliporesigma will discuss the following...
ambr® 250 high throughout perfusion is a parallel bioreactor system for rapid development of scalable perfusion processes using 100 – 250 mL single-use bioreactors and a fully automated liquid handling platform. The system supports the typical range of hollow fibre cell retention applications, with up to 24 fully single-use perfusion bioreactors in parallel. This step change in perfusion process development capability dramatically accelerates optimization of intensified cell culture processes leading to lower production volumes and reduced cost of goods.
ambr® 250 high throughput perfusion is a parallel bioreactor system for rapid development of scalable perfusion processes using 100 – 250 mL single-use bioreactors and a fully automated liquid handling platform.
The Mobius® Power MIX 1000 and 2000 combine high performance mixing technology with design features that make them easy to use. The impeller design and motor are based on our magnetically coupled NovAseptic® mixing technology, a proven mixing technology in stainless steel tanks. The system efficiently mixes the most challenging buffers, media and biopharmaceutical ingredients.