INSIGHTS ON UPSTREAM MANUFACTURING
Expediting Viral-Based Vaccines Development and Increasing Productivity - Part 1 Upstream Processing
We know that speed is of essence and that scale-up to large-scale production needs to be achieved by strategically balancing risks and speed. This presentation first describes how vaccine developers can accelerate their timelines and develop highly efficient vaccine processes by using high throughput fully automatic multi-parallel bioreactor testing tools, DoE software, and single-use solutions able to operate with mammalian cells, insect cells, and avian cells.
Integrated Technologies To Accelerate Process Intensification For Viral Vaccine Manufacturing
With the increasing world-wide demand for viral-based vaccines (VBVs) which includes attenuated and inactivated viral vaccines, as well as viral vector vaccines to protect against the coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), faster development times are required to progress VBVs more rapidly into clinical development and then to market. To facilitate process intensification of VBVs including SARS-CoV-2 vaccine candidates, an integrated portfolio of technologies developed by Sartorius is detailed in this article
Raise Your Upstream IQ: Key Considerations For Optimizing Process Development
How can you intensify your cell culture processes, in order to keep pace with today’s industry and regulatory expectations?
Introducing Cellicon™ Perfusion Filter And Controller
Discover Cellicon™ Perfusion Filter and Controller, a superior perfusion solution for seed train intensification with optimized process control.
Evaluation Of Novel Cell Retention Technology And Cell Culture Media For N-1 Perfused Seed Train
Perfusion operations deliver high density cell cultures that alleviate the burden of processing large production bioreactor volumes while increasing manufacturing flexibility. Introducing perfusion to your seed train makes it possible to inoculate a higher quantity of cells for one or more production bioreactors, thus increasing process efficiency. Read our application note to learn more on the use of cell retention technologies to enable perfusion processes.
Developing TIL Therapies: Sample Collection And Processing
While it has been advanced over many years, the process of developing TIL therapies still suffers from certain challenges. This article attempts to lay bare some of these challenges and discuss how novel technological solutions can help overcome them.
Upstream Intensification – Enabling Perfusion Processes With Cell Retention Technologies
Upstream processes can be intensified using a number of strategies including high cell density cryopreservation, perfused seed train or production processes with high seed fed batch, concentrated fed-batch, ultra-high VCD fed batch, steady-state perfusion, and dynamic perfusion. In this white paper, we explore perfusion processes and how they are becoming a viable solution.
Robust Harvest Clarification For Adeno-Associated Viral Vectors Via Depth Filtration
This article demonstrates that depth filters clarify AAV vectors, helping to overcome the unique separation challenges presented by these important vectors for gene therapy.
UPSTREAM MANUFACTURING SOLUTIONS
Cellicon™ Perfusion Filter And Controller
The benchtop Cellicon™ Perfusion Solution is designed to meet your perfused seed train challenges.
Cellicon™ Perfusion Filter and Controller Brochure
Cellicon™ Perfusion Solution is a superior cell retention solution for seed train intensification with optimized process control.
Cellicon™ Perfusion Filter and Controller Data Sheet
The benchtop Cellicon™ Perfusion Solution is designed to meet your perfused seed train challenges. It consists of a controller and a flat sheet cell retention filter with a single-use assembly running in tangential flow filtration mode. This easy‑to‑use solution increases perfusion process efficiency, and provides real-time monitoring and control for reliable and consistent performance.
EX-CELL® Advanced HD Perfusion Media
EX-CELL® Advanced HD Perfusion Medium is a chemically defined cell culture medium designed specifically for intensified perfusion processes with Chinese Hamster Ovary (CHO) cells. This medium was developed to reach and maintain high cell densities at low cell specific perfusion rates (CSPR), while supporting high volumetric productivities of monoclonal antibodies and recombinant proteins in suspension culture.
A Future-Proof Solution For Bioprocess Applications
The new Eppendorf Flexible Bioreactor Control System evolves with the changing needs of modern biotechnology. Read insights from Dr. Stephan Zelle and Dr. Berit Cleven about Eppendorf’s approaches to optimizing process development.