INSIGHTS ON UPSTREAM MANUFACTURING

• De-Risking Cell Culture Media Scale-Up For Late-Stage Manufacturing

  Explore practical approaches to scaling cell culture media manufacturing, from supply assurance to evolving quality requirements, digital formulation tools, and strategies for controlling costs.

• Building A GMP-Ready Cell Line Development Strategy From Day One

  Embedding manufacturing and regulatory readiness early streamlines development, reduces delays, and supports successful scale-up.

• Accelerating A Promising Bispecific Antibody To The Clinic

  See how an integrated perfusion and intensified fed-batch approach enabled rapid development of a sensitive protein process and successful clinical trial material production.

• Intensification Of Upstream Operations With Dynamic Perfusion

  Dynamic perfusion simplifies continuous cell culture by eliminating cell bleed. Compare upstream strategies across productivity to understand their potential for more efficient mAb production.

• Saving Time And Money With Better Microbial Strain Selection

  9/2/2026

  Deeper, automated E. coli screening can reduce cell line development costs by narrowing the design space, lowering the marginal cost of additional experiments, and improving downstream productivity through higher titers and cleaner harvests.

• Analytical Blind Spots That Derail Microbial Programs Before The Clinic

  9/1/2026

  High refolding yields aren’t enough. Learn how analytical characterization, structural equivalence testing, and optimized fermentation reduce scale-up risk and improve quality.

• Single-Use Clarification Across Process Scales

  9/1/2026

  Gain insight into how combining centrifugation with targeted depth and chromatographic clarification can reduce filter demand, ease facility constraints, and support efficient mAb harvest.

• Optimizing mAb Production: Upstream Process Intensification Strategies

  9/1/2026

  See how integrated upstream and downstream intensification strategies can increase monoclonal antibody yield, streamline workflows, improve facility utilization, and reduce manufacturing costs.