Stem cell-derived cortical neurospheres are of great interest in basic neurobiology research and drug research. Cultivation in controlled, stirred-tank bioreactors can improve the homogeneity of neural spheroid cultures and allows culture scale-up.The ability to generate high numbers of homogenous human iPSC-derived neurospheres will contribute towards personalized drug testing in microphysiological systems. This application note demonstrates using a DASbox Mini Bioreactor System for the generation of human induced pluripotent stem cell (hiPSC) spheroids and subsequent neural differentiation.
A helpful guide through all steps of a bioprocess, starting from the preparation of the inoculum to the preparation and operation of the vessels and bioprocess systems, the bioprocess run itself, and the analysis of samples.
In this study, we successfully demonstrated large-scale culture of human adipose-derived mesenchymal stem cells (AdMSCs) in an industrial, single-use vessel at 3.75 L scale and demonstrate the fact that the process can be conveniently scaled up to industrial levels of production without having to rely on stainless steel culture facilities.
Alternative to water baths for thawing frozen cells
Freezing cells without liquid nitrogen
Sterile filtration of liquids is vital to minimizing microbial contamination and ensuring product safety and integrity. Understanding the criteria for optimum filtering helps streamline product selection.
This video will give you an introduction on the Xuri™ W25 cell expansion system. You’ll get an overview of the system control capabilities which make it suitable for use in a regulated environment, and its flexibility to handle multiple indications with various cell types.
This video provides and overview on the Sefia™ cell processing system, The overview will show the intuitive interface with augmented process control and integrated traceability, easy to implement at your cell therapy activities.
This video provides an introduction to the Sepax™ C-Pro, cell processing system, showing how to start a procedure and preparing and installing the corresponding kit.
Watch this video to learn the important decisions that each biopharma executive must make to break down roadblocks during the critical first step of cell line development and bring their molecule to clinic successfully.
A next-generation bioprocess control station, designed as a universal platform capable of meeting the ever changing needs of all segments of the biotech and pharmaceutical sciences.
A bioreactor/fermentor control station for heat-blanketed and water-jacketed glass vessels and single-use vessels from 250 mL to 40 L.
Choose the right process development and manufacturing partner to guide your company through the many parameters along the drug development process.
Flexible, reliable control and bioreactor systems for laboratory applications
Thermo Scientific™ HyPerforma™ bioprocess control systems are designed to optimize your process from the laboratory bench to full cGMP manufacturing. Our innovative control platform combines a flexible operating system with scalable, modular hardware, novel single-use sensors, and state-of-the-art bioreactors for strategic and streamlined bioprocess control.
HyPerforma benchtop solutions offer robust management of both cell culture and fermentation processes. The open architecture provides process flexibility, and dedicated hardware control allows for expansion. Thermo Scientific™ TruBio™ software is designed to support easy process control and scaling.
Flexible, reliable control and bioreactor systems for laboratory applications.