INSIGHTS ON DOWNSTREAM MANUFACTURING
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Identify And Quantify AAV Fill States Using Analytical Ultracentrifugation
Explore how to implement analysis using sedimentation velocity analytical ultracentrifugation (SV-AUC) to characterize AAV size distributions using multiple detection wavelengths to identify various fill states in AAV preparation.
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Viral Clearance Capability Of POROS Hydrophobic Interaction Chromatography Resins
The present study highlights the viral clearance performance of POROS HIC resins, either in FT or B/E mode, in the purification process of two monoclonal antibodies.
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Using Affinity Chromatography For The Purification Of Lentiviral Particles
This new new affinity chromatography resin offers an efficient and scalable purification method for lentiviral particles in combination with gentle elution conditions to retain viral infectivity.
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Sterilizing Grade Filter Performance With Biologic Drugs
Here, we analyze the throughput performance of sterilizing grade filters across moderate-to-high concentrations of mAbs and immunoglobulins and demonstrate how filter selection can impact your process.
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Enable Custom Chromatography Solutions For Downstream Processing3/8/2024
This study explores the development of a POROS prototype resin, investigating ligand immobilization, optimizing coupling conditions, and evaluating bead morphology impact on resin performance.
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Aggregate Removal From mAbs By Hydrophobic Interaction Chromatography3/7/2024
Review the results of a study where Hydrophobic Interaction Chromatography (HIC) techniques were used with a resin for the removal of aggregates in the manufacturing of monoclonal antibodies.
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Selecting Container Closure Systems With Confidence: Lyophilization3/7/2024
Experts take you through the entire selection process for primary packaging components for lyophilization and provide aspects to consider for all relevant attributes.
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Single-Use Microbial Impactor On A Filling Line3/6/2024
Discover the advantages of a single-use microbial impactor through a demonstration of its ease of use in an isolator and an explanation of its ability to eliminate false positives.
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Exosome Isolation By TFF And Size Exclusion Chromatography3/6/2024
Here, we demonstrate a scalable workflow for the isolation of exosomes that combines tangential flow filtration for the concentration of exosomes followed by gentle size exclusion chromatography.
DOWNSTREAM MANUFACTURING SOLUTIONS
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Learn in detail about a benchtop tangential flow filtration system that enables highly efficient diafiltration of biomolecular solutions in a continuous, single pass process.
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Explore detailed insights into self-contained tangential flow filtration cassettes for continuous diafiltration with low buffer consumption matching conventional diafiltration performance in one pass.
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Looking for a more affordable source of Protein A resin?
Thermo Scientific™ MabCaptureC™ affinity matrix is a high-performance Protein A chromatography resin, specifically designed to help improve the productivity and efficiency of your antibody purification process.
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New Sartorius Hipersep Flowdrive Pilot Preparative HPLC Chromatography System, serial number 3998-H, built 2022.
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Discover technologies that can revolutionize downstream processing in biotherapeutic commercialization with a variety of commercialized resins for affinity, ion exchange, and hydrophobic interaction chromatography (HIC) applications.