INSIGHTS ON DOWNSTREAM MANUFACTURING
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![Aligning Upstream And Downstream Development (Part 1)]( "Aligning Upstream And Downstream Development (Part 1)")
Aligning Upstream And Downstream Development (Part 1)In this episode of “Better Biopharma,” panelists from the Bioprocess Online Live event “Optimizing Process Development Through Upstream And Downstream Integration” continue their conversation about how upstream and downstream development teams can work together to accelerate timelines and reduce risks and bottlenecks in process development.
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![GettyImages-2024514092-vaccine-production-line-facility]( "How To Select The Right Platform For Your Vaccine Production Process")
How To Select The Right Platform For Your Vaccine Production ProcessEvaluate surface treatments, scalability, and contamination risks to select the right adherent platform. Testing early ensures a seamless transition from benchtop to production.
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![GettyImages-1266320932 syringe, filling, lab]( "Why Flexible, Tailored CDMO Support Is A Non-Negotiable In Sterile Fill-Finish")
Why Flexible, Tailored CDMO Support Is A Non-Negotiable In Sterile Fill-FinishModern injectable programs require adaptable manufacturing strategies. Learn how flexibility, technical depth, and collaboration reduce complexity, manage change, and protect long‑term supply.
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![Scientists in lab-GettyImages-1441665026]( "Optimize Time, Space and Cost With Inline Buffer Formulation And System")
Optimize Time, Space and Cost With Inline Buffer Formulation And SystemDiscover how integrating inline buffer formulation with chromatography reduces buffer waste by 50% and delivers a 710% ROI, transforming downstream efficiency and sustainability.
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Evaluation Of TFF Operating Control Strategies And Scalability4/2/2026
Gain insight into a comparison of TMP and permeate control strategies for viral vector TFF, highlighting impacts on flux, processing time, impurity removal, and scale-up predictability across development.
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The Effect Of Conventional Cooling Versus Controlled Ice Nucleation On Primary Drying Time4/1/2026
See how controlled ice nucleation shortens lyophilization cycles, supports higher drying temperatures, and reduces complexity for amorphous and mixed formulations without sacrificing quality.
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Performing Virus Clearance Studies With Retroviral-Like Particles: Updated Guidance3/26/2026
Updated regulatory standards now support using non-infectious retroviral-like particles for viral clearance. This shift reduces costs and accelerates timelines for biomanufacturers.
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A Gentler Workflow: Fc-fusion Protein Purification With Mixed-Mode And Anion Exchange Chromatography3/26/2026
Gain insights into comparative performance, workflow flexibility, and practical considerations for implementing a new weak anion exchange hydrophobic resin and a strong anion exchange resin.
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WuXiHigh 2.0 Delivers A 180 mg/mL Formula3/26/2026
This case study shows how smart formulation and integrated development achieved a stable 180 mg/mL biologic for subcutaneous delivery, for teams tackling concentration issues.
DOWNSTREAM MANUFACTURING SOLUTIONS
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![West-PFS SYRG-0178 NovaPure]( "An Integrated, Verified PFS System For Vaccines")
A pre-verified delivery platform eliminates redundant testing, simplifies regulatory submissions, and optimizes inventory management, allowing teams to focus on drug-specific performance.
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![West-SBO 2 - GCApp_Instron]( "Freeze Your Device Design With An Integrated, Verified PFA System")
Leverage a pre-verified, integrated syringe platform. Accelerate timelines and reduce costs by eliminating drug-independent testing while streamlining regulatory submissions through one source.
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![Bausch Advanced Tech Isolated Filling and Closing Machine, Type 515]( "Advanced Isolated Filling And Closing Machine")
Lightly used Bausch Advanced Technologies isolated filling and closing machine, type 515, currently set up for 5mL BD Luer Syringes and Luer Caps, speeds up to 30/minute. Capable of handling 1mL to 30mL syringes with change parts at additional cost, 3 phase, 208 volt, 60 hertz, 14 kw, serial# 515031, built 2021.
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![Watson-Marlow Flexicon Aseptic Filler, Model Cellefill Ibio]( "Fill Up To 25 Vials Per Minute")
Unused Watson-Marlow Flexicon (WMFTS) vial filler, Type Cellefill Ibio, designed for biohazard applications (OEB Level 3-4). Fills up to 25 vials per minute with Flexicon integrated peristaltic pump infeed. Features IPC via built-in load cell with automatic feedback, stoppering, and crimp capping for flip-top caps with built-in force measurement. Pick-and-place discharge, EM monitoring, SQL database data collection, and automatic vial size adjustment. Built 2022.
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![Unused Groninger Aseptic Vial Filling Line, Model RFVG-200]( "Aseptic Vial Filling Line")
Unused Groninger Aseptic Vial Filling Line, speeds up to 150 vials/minute. Line is designed to CE-norms. Set up for 3 mL, 5 mL with 13mm neck size, 10R, 10Ml, with 20mm neck size, speeds up to 150 vials/minute, 20H, with 20mm neck size, speeds up to 60 vials/minute, and 30mL with 20mm neck size range, speeds up to 50 vials/minute.
