Oncolytic viruses constitute a new promising therapeutic approach for treatment of cancer. Here’s an example of a scalable, end-to-end process for oncolytic adenovirus production using modern tools and technologies.
New modalities, like bispecific antibodies, present unique challenges compared to mAb production. For purification, there’s not just one right answer to which strategy to use. Here are some industry insights to help you navigate the bispecific jungle.
Bispecific antibodies (BsAb) can, in early screening phases, be purified using protein A chromatography in a single step. In this study, BsAb constructs were efficiently purified using a one-step approach, saving 4 to 6 weeks.
This application note describes a flexible and scalable chromatography platform suitable for the purification of monoclonal antibodies of different isoelectric points (pI) and physical properties.
This study shows that CHT XT is capable of minimizing the aggregate content during mAb purification. It can also reduce other product- and process-related impurities to significantly low levels.
Compare two purification strategies and their effectiveness to offer high product yields and clearance of acidic impurities from the expression host cells.
This video introduces Singota Solutions, a CDMO focused on getting products to patients faster by being agile, accountable and transparent. A team of industry experts help virtual to large pharma clients reach preclinical and clinical milestones faster with shorter lead times and agile onsite operations. Services in formulation development, finishing and supply chain support Singota’s flagship aseptic filling operations. A gloveless robotic isolator provides highly repeatable and precise filling for high value drug products.
Hear how an adaptive and evolving platform of proven and novel technologies enables biomanufacturers to successfully accomplish their bioprocessing goals through either intensified, connected or continuous bioprocessing.
As the industry is looking to increase speed to market, reduce manufacturing resources and increase product safety, there has been a push to implement single-use technologies. Combining both SPTFF and single-use technology can be a powerful tool for the efficient manufacture of biologics.
Where sterility will be claimed, regulatory agencies worldwide require that the integrity of sterilizing-grade filter(s) is verified before and after use to ensure filter performance. This webinar highlights best practices and key considerations for performing filter integrity tests to give you a better understanding of how to design a robust integrity test operation in your own facility.
Understanding the source, options for control, and potential impact of bioburden throughout downstream biopharmaceutical processes is beneficial to process developers, production operators and pharmaceutical microbiologists. Process designs that reduce the risks of bioburden contamination will decrease process related failures and the resulting painful, time-consuming investigations.
Fermentation is a critical step in both drug and toll manufacturing, as companies look to produce the core compounds that form their eventual products. While it is possible to undertake this in-house, the expertise contract fermentation services provide can improve the quality, affordability, speed and scalability of your program.
AbbVie Contract Manufacturing offers world-class fermentation capabilities based on more than 60 years’ leadership in fermentation. Your project will benefit from AbbVie’s scientific expertise as a leading developer and manufacturer of fermentation processes at our 180-acre facility in North Chicago, Illinois. We bring the same degree of expertise and passion to your project as we do with our own – supporting you from strain improvement through to large-scale manufacturing.
AbbVie Contract Manufacturing offers development to commercial manufacturing services for prefilled syringes at our Barceloneta and Lake County facilities. Barceloneta is one of the world’s most advanced facilities for biologics syringe filling and Lake County has broad packaging services from blister packs to auto-injectors.