INSIGHTS ON DOWNSTREAM MANUFACTURING

  • Sterilizing Grade Filtration Unit Operations For Plasmid DNA Processes

    The large size of pDNA can present a challenge for sterile filtration unit operations within your gene therapy manufacturing since the product can be retained by the filters, leading to both yield loss and low filtration capacity. Optimization of a sterilized grade filtration unit can help increase yield and filtration capacity. Read on to learn more!

  • Chromatographic Purification Of Plasmid DNA

    Widespread application of pDNA in gene therapy is driving increased demand and as a response, plasmid manufacturing must become more efficient with improved productivity. Intensification of chromatographic steps can help address this demand and has led to an exploration of the use of convective media (monoliths, membranes, fibre based technologies).

  • Optimize Scale-Up And Increase Capacity For Vaccine And Therapeutic Manufacturing

    In order to accelerate development and manufacturing in the era of SARS-CoV-2, companies are designing scale-up processes in parallel with Phase III clinical trials, redefining the risk tolerance for everyone involved. Read this article to consider a new way of doing business by reviewing existing capabilities, assessing risk tolerance, and identifying key resources to accomplish your goals.

  • A Shot In The Arm For mRNA Vaccines

    Standard methods of preparing mRNA require multiple purification steps, sometimes-costly single- use resins, and various chemicals. At the commercial scale, such methodology is impractical; at the vaccine scale (hundreds of millions of doses per annum), it is impossible.

DOWNSTREAM MANUFACTURING SOLUTIONS

  • Ajinomoto Drug Product Fill Finish Capabilities

    Ajinomoto Bio-Pharma Services offers a unique range of formulation and aseptic filling in vials, prefilled syringes or cartridges to address production needs that span from small early stage clinical products to larger scale commercial products.

  • Series 4000™ Single-Round Filter Housings Datasheet

    The Series 4000™ single-round filter housing line provides a range of pre-configured designs to meet all your process and filtration needs. It is available in T-Line and In-Line designs, with a wide range of tube sizes.

  • Series 4000™ Single Round Filter Housings

    New family of our housing portfolio designed to meet the demands of filtration process design. Series 4000™ housings have been designed in accordance with the life sciences industry’s demand for high-quality and cost-effective products. Our Series S4000™ housings are suitable for use in a wide range of applications with low dead volume, minimizing product loss and enhancing cleanability. The products are available in T-Line and In-Line configurations including the 5, 10 ,20, 30-inch sizes in Code 7.

  • Mobius® Chrom 20 System

    The Mobius® Chrom 20 system is a flexible, automated, single-use chromatography system that enables consistent and reliable separation and purification of mAbs, vaccines, plasma, and therapeutic proteins at clinical and process scales.

  • Mobius® Chrom 20 System Datasheet

    The Mobius® Chrom 20 system is a flexible, automated, single-use chromatography system that enables consistent and reliable separation and purification of mAbs, vaccines, plasma, and therapeutic proteins at clinical and process scales.