Repligen Process Analytics

  1. Ensure Batch-To-Batch Media Consistency Before Starting Your Bioprocess 1/28/2022

    RPMI media is often supplemented with fetal bovine serum, which can create analytical challenges. Mass spec-based platforms can help simplify the analysis.

  2. Analytics-Based Process Development Strategy By Monitoring Amino Acids In Insect Cell Media 1/27/2022

    Knowledge of insect cell metabolism coupled with understanding of the amino acid content of the cell media allows for more informed process development.

  3. How To Monitor Consistency In MSC 1/27/2022

    To ensure consistency when culturing MSCs, researchers should understand what is being added to their media using frequent at-line cell culture media analysis.

  4. Which Cell Culture Media Is Right For Your T-Cells? 1/26/2022

    Serum-free media may yield lower CAR-T efficacies, so understanding how to optimize the media to improve the therapy is a necessary step.

  5. Screening Of Chemically-Defined Media For Suspension Cultures Of HEK293 Cells 1/26/2022

    Regular cell media analysis can establish a historical record to refer to in case any unexpected variations arise in the culture’s health and productivity.

  6. Handle Non-Ionic Surfactants In Cell Media Samples With Ease 1/25/2022

    Non-ionic surfactants like Tween 20 and Tween 80 can interfere with traditional chromatographic analysis. At-line mass spec devices can bypass that complexity.

  7. Cell Culture Media Analysis You Can Trust– Even If There's Antifoam 1/25/2022

    Media additives may interfere with the chemical analysis of samples taken during a bioprocess. At-line mass spec devices can help sidestep the complexity.

  8. Simply Monitor Vitamin Levels During Cell Media Analysis 1/21/2022

    Vitamins have various shelf lives and may be prone to degradation from changes in temperature, oxygen or light exposure. Quick, at-line analysis is critical.

  9. Are You Getting The Cell Culture Media You Expected? 1/21/2022

    Consistency between cell culture media vendors should not be assumed. In some cases, certain media components can be as high as 2.5x the expected values.

  10. Identify Variations In Chemically-Defined CHO Media Dry And Liquid Formulations 1/20/2022

    Running a quick media assay prior to a run ensures consistency of the media components during the transition between liquid-to-dry media blends.