On-Demand Downstream Manufacturing Webinars

  1. Identify And Quantify AAV Fill States Using Analytical Ultracentrifugation 3/14/2024

    Explore how to implement analysis using sedimentation velocity analytical ultracentrifugation to characterize AAV size distributions and multiple detection wavelengths to identify various fill states in AAV preparation.

  2. AAV Purification Using AEX And Mixed-Mode Chromatography 1/26/2024

    Recombinant adeno‐associated viruses (rAAVs) are among the most promising vectors for long‐term gene transduction. In this study, we explore chromatography workflow solutions to purify rAAV8.

  3. Polishing Strategy For Removing Impurities In bsAb Purification 1/26/2024

    This demonstration showcases a Bispecific antibodies (bsAbs) polishing strategy that utilizes a multimodal chromatography media to address the unique challenges presented by bsAb downstream processing.

  4. Osmolality Analysis In Bioprocessing: From Theory To Practice 1/23/2024

    Gain deeper insight into the significant impact of osmolality in bioprocessing and its correlation with immunoglobulin G (IgG) production.

  5. Optimization-By-Design — A Critical Factor In Viral Vector Scale Up 12/14/2023

    Learn how leveraging the expertise and capabilities of an experienced partner is a key factor in optimizing AAV processes using Design of Experiment (DoE), thereby reducing variability and risk.

  6. Cost Efficient Manufacturing Of Purer AAV Gene Therapy Vectors 12/13/2023

    Review a comparison of the cation exchange and affinity column for the first column step, and learn how the new CIMmultus High Reproducibility (HR) line columns are used for the polishing step.

  7. Upstream To Downstream: A Comprehensive Approach To AAV Production 12/7/2023

    How can you face the challenges of AAV production, scale up your AAV manufacturing effectively, and enhance the recovery and purity in your downstream processing.

  8. Demonstrating Effective Scaling Of Rapid Cycling Chromatography 11/28/2023

    Here, we introduce Rapid Cycling Chromatography (RCC), explore how membranes can remove the chromatography bottleneck, and demonstrate the scalability of a unique membrane for RCC.

  9. Adopting Novel Technologies To Improve Monoclonal Antibody Processes 11/15/2023

    What are the four new-edge production technologies that better remove impurities, reduce aggregation and improve stability

  10. Strategies To Improve Protein A Resin Cost Effectiveness 11/9/2023

    Explore innovative process intensification strategies and practical applications to increase resin utility, resulting in improvements in costs and time efficiencies in protein A affinity capture.