Boost Process Efficiency With Our New mAb Optimized TFF Cassette

The growing demand for higher monoclonal antibody (mAb) concentrations is pushing traditional tangential flow filtration (TFF) systems to their limits. Achieving these goals requires solutions that balance high throughput with moderate pump rates, while maintaining cleanability and consistent performance. Recent evaluations of a 30 kDa membrane paired with an innovative screen design reveal how these advancements can support modern mAb processing. Key performance factors, such as viscosity handling, flux and pressure profiles, protein retention, and scalability, were tested across multiple protein and antibody solutions. Beyond technical performance, usability and sustainability considerations, including cleaning efficiency and reduced pre- and post-use times, were also assessed.

Gain insights into how screen types influence concentration, the interplay between buffer water flux and protein flux, and why scalability and sustainability are critical for next-generation TFF processes.